scholarly journals Prevention and/or recovery from corona virus infections

2020 ◽  
pp. 022-024
Author(s):  
Ober Clinton ◽  
Oschman James L
Keyword(s):  
Virus Infections ◽  
Corona Virus

scholarly journals Seasonality of non-SARS, non-MERS Corona viruses and the impact of meteorological factors

2020 ◽  
Author(s):  
Olympia E Anastasiou ◽  
Anika Huesing ◽  
Johannes Korth ◽  
Fotis Theodoropoulos ◽  
Christian Taube ◽  
...  
Keyword(s):  
Relative Humidity ◽  
Cloud Cover ◽  
Detection Rate ◽  
Meteorological Factors ◽  
Seasonal Pattern ◽  
Virus Detection ◽  
Virus Infections ◽  
Weather Factors ◽  
Corona Virus ◽  
Corona Viruses

Background: Seasonality is a characteristic of some respiratory viruses. The aim of our study was to evaluate the seasonality and the potential effects of different meteorological factors on the detection rate of the non-SARS Corona Virus detection by PCR. Methods: We performed a retrospective analysis of 12763 respiratory tract sample results (288 positive and 12475 negative) for non-SARS, non-MERS Corona viruses (NL63, 229E, OC43, HKU1). The effect of seven single weather factors on the Corona virus detection rate was fitted in a logistic regression model with and without adjusting for other weather factors. Results: Corona virus infections followed a seasonal pattern peaking from December to March and plunging from July to September. The seasonal effect was less pronounced in immunosuppressed patients compared to immunocompetent. Different automatic variable selection processes agreed to select the predictors temperature, relative humidity, cloud cover and precipitation as remaining predictors in the multivariable logistic regression model including all weather factors, with low ambient temperature, low relative humidity, high cloud cover and high precipitation being linked to increased Corona virus detection rates. Conclusions: Corona virus infections followed a seasonal pattern, which was more pronounced in immunocompetent patients compared to immunosuppressed. Several meteorological factors were associated with the Corona virus detection rate. However, when mutually adjusting for all weather factors, only temperature, relative humidity, precipitation and cloud cover contributed independently to predicting the Corona virus detection rate.

scholarly journals A Precursor on Pandemic Corona Virus: An Infectious Disease

2020 ◽  
Vol 8 (3) ◽  
Author(s):  
Narmathadevi V ◽  
Ramya K ◽  
Kishore Balasubramanian ◽  
Das J
Keyword(s):  
Rna Virus ◽  
Human Beings ◽  
Virus Infections ◽  
Key Factors ◽  
Respiratory Problems ◽  
Corona Virus ◽  
Global Pandemic ◽  
Children And Young Adults ◽  
Local Risk ◽  
Corona Viruses

This paper is a study on Corona virus and its effects on human beings in particular and how it has become a global pandemic. The reason for the world’s pandemic, Corona virus is an RNA virus found extensively in mammals including humans. It is found that the most human corona virus infections cause from mild symptoms to severe respiratory problems and lead to death. In the recent past the world has faced two great epidemics caused by two different beta-corona viruses and they were named as SARS-CoV (Severe Acute Respiratory Syndrome Corona Virus) and (MERS-CoV Middle East Respiratory Syndrome Coronavirus). Despite these viruses had high infectivity, had less mortality rate. As it is known, these types of viruses, in general, cause a mild illness and considerably affect children and young adults.  As the whole world is facing a pandemic situation today, carrying out research on finding vaccine to kill the virus is a need of the time. It is obvious that to understand the fighting measurements, in other words readiness of the nation in handling the situation, the local risk assessments are considered to be one of the key factors in comprehending COVID-19. It is pathetic to know that this virus spreads rapidly everywhere and considering this fast outbreak, the global wide readiness, building capacity and mutual collaborations among countries are the most important needs in order to control the outbreak.

scholarly journals Detection techniques aiding in the diagnosis of the novel coronavirus SARS-Cov-2 induced infections

2021 ◽  
Vol 2 (2) ◽  
pp. 112-115
Author(s):  
Chateen Izaddin Ali Pambuk ◽  
Fatma Mustafa Muhammad
Keyword(s):  
Elisa Test ◽  
The Novel ◽  
Virus Infections ◽  
Detection Techniques ◽  
Corona Virus ◽  
Polymerase Chain ◽  
Antigen Tests ◽  
Novel Coronavirus ◽  
Antibody Tests ◽  
Shed Light

Some people may not be able to distinguish between the symptoms of the emerging corona virus 2019 and other respiratory diseases, and some individuals may be infected with the virus without symptoms, or without noticeable symptoms, so it is important to conduct a corona examination to diagnose the disease. To monitor the new Corona virus infections, many tests have been developed since the SARS-Cov 2 virus first appeared at the end of last year until today. About 350 types of detection techniqes are currently used in all laboratories of the world. They can be divided into three pivotal sections: the [PCR] examination, which is also known as the "polymerase chain reaction" examination, then the [antigen-tests] known as antibody tests, and finally the ELISA test. The aim of this descriptive minireview, generally, is to shed light on the main detection techniques used in Covid 19 diagnosis.

scholarly journals Ribosomal Proteins Homologies and Methylation of Mitoribosome by Corona Virus Nsp9, Nsp10 and Previously Described Nsp13-16 Proteins Suggested Their Roles in the Inhibition of Host Protein Synthesis: Discovery of New Therapeutic Targets against Corona Virus Infections

2020 ◽  
Author(s):  
Asit Kumar Chakraborty
Keyword(s):  
Protein Synthesis ◽  
Ribosomal Protein ◽  
Ribosomal Proteins ◽  
Mitochondrial Protein ◽  
Atp Synthesis ◽  
Host Protein ◽  
Virus Infections ◽  
Corona Virus ◽  
Computer Based ◽  
Novel Drug

Multi-Alignment method coupled with phylogenetic analysis we disclosed the Nsp9 and Nsp10 non-structural proteins of Corona Virus as rRNA RlmH/K methyltransferases with similarities with bin recombinase and int-core integrase fold. Further, Nsp9 has similarities to S8 ribosomal protein and Nap10 has similarity to S10 ribosomal protein. Previously, we showed Nsp13, Nsp14, Nsp15 and Nsp16 are also different types of rRNA RlmE/N and Cfr-like methyltransferases-ribonuclease with RNA helicase domains. Two domains of Nsp13 astonishingly have similarities to ribosomal proteins L6 and L9. Taken together, Nsp9/10 and Nsp13-16 proteins could mimic host ribosome assembly and also could methylate rRNA of mitobibosome preventing mitochondrial protein synthesis and oxidative phosphorylation. Low ATP synthesis causes lowering blood pressure following coma but very ATP concentration (1-10nM) surely induces platelets aggregation through vWA, collagen and GpIIb/IIIa proteins followed by fibrin formation and blood clotting as recently have seen in the lung of many Corona virus infected patients. We have also postulated that two polyproteins itself resemble like 28S and 38S mitoribosome subunits and compete with rRNAs inhibiting the ribosome turnover and new protein synthesis due to their similarities with many ribosomal proteins. Such finding may be valuable in computer-based novel drug design against Corona virus.

Fragment Tailoring Strategy to Design of Chemical Entities as Potential Binders of Novel Corona Virus Main Protease

2020 ◽  
Author(s):  
chinmayee choudhury
Keyword(s):  
Free Energy ◽  
Binding Site ◽  
Rna Virus ◽  
Binding Free Energy ◽  
Free Energy Calculations ◽  
Virus Infections ◽  
Corona Virus ◽  
Main Protease ◽  
Dynamics Simulations ◽  
Tract Infections

<p>The recent pandemic of novel corona virus infections (COVID19) has put the world on serious alert. This is caused by a recent form of a positive sense RNA virus (nCoV) of coronaviridae family which is known to cause respiratory tract infections in humans. Absence of any specific drugs, vaccines or treatment measures for this deadly virus warrants intense research to design new chemical entities in order to inhibit the viral replication in human cells. The main protease of nCov (nCov-MP) cleaves the long polyprotein chains to release functional proteins required for replication of the virus and thus is a potential drug target. The current study employs state of are computational methods to design new molecules by linking molecular fragments which specifically bind to different constituent sub-pockets of the nCov-MP binding site. A huge library of 191678 fragments was screened against the binding cavity of nCov-MP and high affinity fragments binding to adjacent sub-pockets were tailored to generate new molecules. These newly formed molecules were further subjected to molecular docking, ADMET property filters and MMGBSA binding free energy calculations to select 17 best molecules (named as MP-In1 to Mp-In17), which showed interactions with the key binding site residues as the reference ligand. Nine out of these 17 molecules with better MMGBSA binding free energy than the reference molecule, were subjected to molecular dynamics simulations, which assessed the stabilities of their binding with nCov-MP. Eight molecules were found to form stable complexes with nCov-MP. These molecules can be further evaluated as potential starting points for nCov drug discovery. </p>

scholarly journals Understanding COVID-19 through the Dental Lens

BioMedica ◽  
2020 ◽  
Vol 36 (2S) ◽  
pp. 185-193
Author(s):  
Sarah Ghafoor ◽  
Ansa Javed Akram
Keyword(s):  
Oral Cavity ◽  
Virus Disease ◽  
Professional Staff ◽  
The Body ◽  
World Health ◽  
Virus Infections ◽  
Corona Virus ◽  
The World ◽  
Precautionary Measures ◽  
Health Organization

<p>Corona virus Disease-19 (COVID-19) is a global health pandemic that has affected life of every individual in the world. It is caused by a novel Corona virus strain that has caused seventh Corona virus infection that has affected human population, named as &ldquo;COVID-19&rdquo; virus by the World Health Organization. Previously, six Corona virus infections have affected humans but those caused by SARS-CoV and MERS-CoV have proved to be more lethal. Angiotensin Converting Enzyme 2 (ACE2) has been found as the receptor for COVID-19 through which cellular entry of the virus is mediated into the body. These receptors are abundantly present in the oral cavity especially on the epithelial cells of the tongue, oral mucosa and the gingiva. Saliva is an oral bio-fluid of the oral cavity in which high titres of the virus have been identified during early and later stages of infection. Saliva collection is a non-invasion method and can act as a diagnostic tool for COVID-19 disease. Common oral symptoms of the disease include transient loss of taste, smell and dryness of mouth. Precautionary measures must be taken by dentist before carrying out any dental procedure for safety of the health care professional, staff and also the patient. Dental community must think of the &ldquo;new normal&rdquo; regarding clinical dental care in light of post-COVID-19 situation.</p>

scholarly journals Implementation of The Policy of The Minister of Health of The Republic of Indonesia Concerning The Health Protocol for The Community in Place and Public Facilities to Press The Spread of Covid-19 in The Sidoarjo Area

2021 ◽  
Vol 9 (1) ◽  
pp. 1-9
Author(s):  
Hendra Sukmana
Keyword(s):  
Public Health ◽  
Prevention And Control ◽  
Virus Disease ◽  
Virus Infections ◽  
Public Places ◽  
Corona Virus ◽  
The People ◽  
The Republic ◽  
The Government ◽  
And Control

The number of positive COVID-19 patients in the Sidoarjo area continues to increase. As of April 19, 2020, there were 11,028 positive COVID-19 patients, 6,068 suspect patients, 617 patients who were declared dead due to Covid-19 and 10,398 people declared cured of Covid-19. This study was conducted to identify and describe the implementation of policies in the form of the Decree of the Minister of Health of the Republic of Indonesia Number HK. 01.07/Menkes/382/2020 concerning Protocols for Public Health in Public Places and Facilities in the Context of Prevention and Control of Corona Virus Disease 2019 (Covid-19) in the Sidoarjo area. Data analysis was carried out by Miles and Huberman interactive analysis. The results showed that the implementation of the Decree of the Minister of Health of the Republic of Indonesia Number HK. 01.07/Menkes/382/2020 concerning Protocols for Public Health in Public Places and Facilities in the Context of Prevention and Control of Corona Virus Disease 2019 (Covid-19) in the Sidoarjo region can be seen from four things. First, communication, where policy communication is carried out through socialization and education related to 3M (wearing masks, maintaining distance and washing hands) to the people of Sidoarjo. However, in practice, socialization and education related to 3M (wearing masks, maintaining distance and washing hands) are considered insufficient to overcome the Covid-19 pandemic. Need to add 2M (limit mobility and stay away from crowds) so that it becomes 5M. This is because mobility and crowd problems are felt to have contributed to causing many Covid-19 virus infections. Second, resources, where the task of fixing the level of compliance with health protocols actually requires the help of many parties. Not only from themselves, the media is also tasked with providing a sense of security and positive messages to the community. Likewise, the government should also not instill too much fear, but rather recommendations that arouse the desire to comply with health protocols.

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