scholarly journals Blood and aqueous humor tumstatin concentrations associated with diabetic retinopathy

2020 ◽  
Vol 3 (1) ◽  
pp. 025-028
Author(s):  
Y Oruc ◽  
S Aydin
Keyword(s):  
Diabetic Retinopathy ◽  
Aqueous Humor

Serum and aqueous humor concentrations of interleukin-27 in diabetic retinopathy patients

2017 ◽  
Vol 38 (5) ◽  
pp. 1817-1823 ◽  
Author(s):  
Maha E. Houssen ◽  
Mona Abo Bakr El-Hussiny ◽  
Amr El-Kannishy ◽  
Dalia Sabry ◽  
Rasha El Mahdy ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Aqueous Humor ◽  
Interleukin 27

scholarly journals Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259683
Author(s):  
Hyun Seung Yang ◽  
Young Je Choi ◽  
Hee Yong Han ◽  
Hak Su Kim ◽  
So Hyun Park ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Growth Factor ◽  
Aqueous Humor ◽  
Normal Subjects ◽  
Intercellular Adhesion Molecule ◽  
Diabetic Patients ◽  
Intercellular Adhesion Molecule 1 ◽  
Logistic Analysis ◽  
Group 2 ◽  
Average Serum

Purpose To compare adiponectin (APN) levels in the serum and aqueous humor (AH) and evaluate their association with the development/progression of diabetic retinopathy (DR). Methods Diabetic patients with (group 3; n = 59) and without (group 2; n = 39) DR and age- and sex-matched normal subjects (group 1; n = 35) were compared. Duration of diabetes, body mass index, serum HbA1c, vascular endothelial growth factor (VEGF), APN, pentraxin 3 (PTX3), platelet derived growth factor (PDGF), intercellular adhesion molecule-1 (ICAM-1), and APN were measured and analyzed. Results One hundred and thirty-three participants were included. Compared to patients without diabetes, diabetic patients with DR had significantly elevated average serum APN levels (5.99±3.89 μg/ml versus 3.51±1.44 μg/ml, P = 0.002) and average AH APN levels (10.94±11.74 ng/ml versus 3.65±3.33 ng/ml, P<0.001). Serum APN was significantly correlated with AH APN (R = 0.512, P<0.001) and AH VEGF (R = 0.202, P = 0.020). The log serum APN was significantly correlated with intraocular cytokines, including log APN, log VEGF, log ICAM, log leptin, log PTX3, log PDGF, angiopoietin, C-reactive protein, and interleukins (IL)-5 and IL-10 (P<0.001, P = 0.020, P<0.001, P<0.001, P = 0.001, P<0.001, P = 0.008, P = 0.009, P<0.001, and P = 0.046, respectively). Log serum VEGF showed a significant correlation only with log AH VEGF (P = 0.001). Multivariate logistic analysis was performed to evaluate the association of DR progression and cytokine concentrations; log Serum APN and log AH APN showed good correlation with the DR progression in each model. Conclusions AH APN levels correlated well with DR development and progression. Serum APN could be a better marker for estimating intraocular cytokines, including both intraocular APN and VEGF concentrations in clinical field, than serum VEGF in DR patients.

scholarly journals Relationships among Retinal Nonperfusion, Neovascularization, and Vascular Endothelial Growth Factor Levels in Quiescent Proliferative Diabetic Retinopathy

2020 ◽  
Vol 9 (5) ◽  
pp. 1462
Author(s):  
Ho Ra ◽  
Jae Hyun Park ◽  
Jin Uk Baek ◽  
Jiwon Baek
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Diabetic Retinopathy ◽  
Growth Factor ◽  
Aqueous Humor ◽  
Proliferative Diabetic Retinopathy ◽  
Peripheral Retina ◽  
Vascular Endothelial ◽  
Disc Area ◽  
Endothelial Growth Factor ◽  
Vegf Level

Purpose: To investigate the relationships among the retinal nonperfusion (NP) area, neovascularization (NV) area, and aqueous humor vascular endothelial growth factor (VEGF) levels in quiescent proliferative diabetic retinopathy (PDR). Methods: Forty-seven eyes from 47 patients with treatment-naïve PDR that did not show macular edema or vitreous hemorrhage were enrolled. NP area, NV number, and NV area were quantitatively measured using ultra-widefield fluorescein angiography in an automated manner. Aqueous humor VEGF level was measured using a bead assay. Results: The NP areas of the total, posterior pole, peripheral retinae, and NV area positively correlated with each other (all p < 0.034). NV number correlated with total NP area, peripheral NP area, and NV area (all p ≤ 0.001). VEGF levels were significantly positively correlated with total, posterior polar, and peripheral NP areas and NV area (r = 0.575, 0.422, 0.558, and 0.362, respectively; all p ≤ 0.012). In eyes with NV in the disc area, the VEGF level was higher compare to eyes without NV in the disc area (208.89 ± 192.77 pg/mL vs. 103.34 ± 132.66, p = 0.010). A multiple linear regression model using NP area, NV area, and NVD demonstrated good prediction for VEGF level (R2 = 0.417, p < 0.001) and revealed a significant contribution of the peripheral NP area in predicting the VEGF level (β = 0.497, p = 0.002). Conclusions: Aqueous humor VEGF levels in quiescent PDR eyes were associated with NP and NV areas, which had positive correlations with each other. In addition, the NP area of the peripheral retina was the most important predictor of VEGF level.

scholarly journals Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy

Life ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1421
Author(s):  
Shermaine W. Y. Low ◽  
Tanuja Vaidya ◽  
Santosh G. K. Gadde ◽  
Thirumalesh B. Mochi ◽  
Devesh Kumar ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Aqueous Humor ◽  
Treatment Strategies ◽  
Enzyme Linked Immunosorbent Assay ◽  
Great Success ◽  
Variable Response ◽  
Compensatory Response ◽  
Cross Sectional ◽  
Chronic Hyperglycemia ◽  
Retinal Microvasculature

Diabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization. Current treatment strategies include intravitreal anti-vascular endothelial growth factor (VEGF) or steroidal injections, laser photocoagulation, or vitrectomy in severe cases. However, treatment may require multiple modalities or repeat treatments due to variable response. Though DR management has achieved great success, improved, long-lasting, and predictable treatments are needed, including new biomarkers and therapeutic approaches. Small-leucine rich proteoglycans, such as decorin, constitute an integral component of retinal endothelial ECM. Therefore, any damage to microvasculature can trigger its antifibrotic and antiangiogenic response against retinal vascular pathologies, including DR. We conducted a cross-sectional study to examine the association between aqueous humor (AH) decorin levels, if any, and severity of DR. A total of 82 subjects (26 control, 56 DR) were recruited. AH was collected and decorin concentrations were measured using an enzyme-linked immunosorbent assay (ELISA). Decorin was significantly increased in the AH of DR subjects compared to controls (p = 0.0034). AH decorin levels were increased in severe DR groups in ETDRS and Gloucestershire classifications. Decorin concentrations also displayed a significant association with visual acuity (LogMAR) measurements. In conclusion, aqueous humor decorin concentrations were found elevated in DR subjects, possibly due to a compensatory response to the retinal microvascular changes during hyperglycemia.

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