scholarly journals Micronucleus scoring: An available approach in the evaluation of genomic damage in exfoliative cervicovaginal cells

2020 ◽  
Vol 5 (1) ◽  
pp. 064-067
Author(s):  
OZ Zehra SAFI
Keyword(s):  
Genomic Damage

Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients

2008 ◽  
Vol 378 (3) ◽  
pp. 283-291 ◽  
Author(s):  
Nicole Schupp ◽  
Eva Maria Dette ◽  
Ursula Schmid ◽  
Udo Bahner ◽  
Michaela Winkler ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Peripheral Lymphocytes ◽  
Genomic Damage

scholarly journals In vitro evaluation of genomic damage induced by glyphosate on human lymphocytes

2018 ◽  
Vol 25 (34) ◽  
pp. 34693-34700 ◽  
Author(s):  
Alfredo Santovito ◽  
Stefano Ruberto ◽  
Claudio Gendusa ◽  
Piero Cervella
Keyword(s):  
Human Lymphocytes ◽  
In Vitro Evaluation ◽  
Genomic Damage

Genomic damage as a biomarker of chronic kidney disease status

2014 ◽  
Vol 56 (3) ◽  
pp. 301-312 ◽  
Author(s):  
Zuray Corredor ◽  
Elitsa Stoyanova ◽  
Lara Rodríguez-Ribera ◽  
Elisabet Coll ◽  
Irene Silva ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Status ◽  
Genomic Damage

scholarly journals Genomic damage induced by the widely used fungicide chlorothalonil in peripheral human lymphocytes

2018 ◽  
Vol 161 ◽  
pp. 578-583 ◽  
Author(s):  
Alfredo Santovito ◽  
Claudio Gendusa ◽  
Francesca Ferraro ◽  
Irene Musso ◽  
Maria Costanzo ◽  
...  
Keyword(s):  
Human Lymphocytes ◽  
Genomic Damage

Genetics and genetic instability in cancer

2019 ◽  
pp. 43-55
Author(s):  
Mark A. Glaire ◽  
David N. Church
Keyword(s):  
Dna Replication ◽  
Human Genome ◽  
Genomic Instability ◽  
Genetic Instability ◽  
Important Determinant ◽  
Human Cancer ◽  
Deleterious Mutations ◽  
Cellular Processes ◽  
Repair Mechanisms ◽  
Genomic Damage

"The Integrity"of the human genome is under continual threat from endogenous and exogenous mutagens, and as a result of errors introduced during DNA replication. As the lesions generated by these processes, if left uncorrected, may lead to deleterious mutations, cells employ several sophisticated mechanisms to both prevent and repair such genomic damage. Failure of these repair mechanisms, leading to genomic instability, is common in cancer, and has even been suggested to be a universal characteristic of malignancy. This chapter outlines these cellular processes and reviews the both the mechanisms and consequences of their dysregulation in human cancer. It also highlights the emerging evidence suggesting that genomic instability is an important determinant of tumour behaviour. Finally, it discusses the possibility that targeting genomic instability may benefit patients with genomically unstable tumours in the clinic.

scholarly journals Association of GSTT1 null, XPD 751 CC and XPC 939 CC genotypes with increased levels of genomic damage among hospital pathologists

Biomarkers ◽  
2017 ◽  
Vol 22 (6) ◽  
pp. 557-565 ◽  
Author(s):  
Alfredo Santovito ◽  
Marta Delsoglio ◽  
Eleonora Manitta ◽  
Giulia Picco ◽  
Giulia Meschiati ◽  
...  
Keyword(s):  
Genomic Damage

scholarly journals Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial

Biomedicines ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. 390
Author(s):  
Premranjan Kumar ◽  
Chun Liu ◽  
James W. Suliburk ◽  
Charles G. Minard ◽  
Raja Muthupillai ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Clinical Trial ◽  
Cognitive Decline ◽  
Muscle Protein ◽  
Glucose Production ◽  
Premature Aging ◽  
Open Label ◽  
Breakdown Rates ◽  
Genomic Damage

Background: Patients with HIV (PWH) develop geriatric comorbidities, including functional and cognitive decline at a younger age. However, contributing mechanisms are unclear and interventions are lacking. We hypothesized that deficiency of the antioxidant protein glutathione (GSH) contributes to multiple defects representing premature aging in PWH, and that these defects could be improved by supplementing the GSH precursors glycine and N-acetylcysteine (GlyNAC). Methods: We conducted an open label clinical trial where eight PWH and eight matched uninfected-controls were studied at baseline. PWH were studied again 12-weeks after receiving GlyNAC, and 8-weeks after stopping GlyNAC. Controls did not receive supplementation. Outcome measures included red-blood cell and muscle GSH concentrations, mitochondrial function, mitophagy and autophagy, oxidative stress, inflammation, endothelial function, genomic damage, insulin resistance, glucose production, muscle-protein breakdown rates, body composition, physical function and cognition. Results: PWH had significant defects in measured outcomes, which improved with GlyNAC supplementation. However, benefits receded after stopping GlyNAC. Conclusions: This open label trial finds that PWH have premature aging based on multiple biological and functional defects, and identifies novel mechanistic explanations for cognitive and physical decline. Nutritional supplementation with GlyNAC improves comorbidities suggestive of premature aging in PWH including functional and cognitive decline, and warrants additional investigation.

scholarly journals Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Olivia Torres-Bugarín ◽  
Nicole Macriz Romero ◽  
María Luisa Ramos Ibarra ◽  
Aurelio Flores-García ◽  
Penélope Valdez Aburto ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Micronucleus Test ◽  
Genetic Material ◽  
Genotoxic Effect ◽  
Invasive Test ◽  
Genome Damage ◽  
Organ Specific ◽  
Genomic Damage

Autoimmune diseases (AD) are classified into organ-specific, systemic, and mixed; all forms of AD share a high risk for cancer development. In AD a destructive immune response induced by autoreactive lymphocytes is started and continues with the production of autoantibodies against different targets; furthermore apoptosis failure and loss of balance in oxidative stress as a consequence of local or systemic inflammation are common features seen in AD as well. Micronucleus (MN) assay can be performed in order to evaluate loss of genetic material in a clear, accurate, fast, simple, and minimally invasive test. The MN formation in the cytoplasm of cells that have undergone proliferation is a consequence of DNA fragmentation during mitosis and the appearance of small additional nuclei during interphase. The MN test, widely accepted forin vitroandin vivogenotoxicity research, provides a sensitive marker of genomic damage associated to diverse conditions. In here, we present a review of our work and other published papers concerning genotoxic effect in AD, identified by means of the MN assay, with the aim of proposing this tool as a possible early biomarker for genotoxic damage, which is a consequence of disease progression. Additionally this biomarker could be used for follow-up, to asses genome damage associated to therapies.

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