scholarly journals Directed Search of Biologically Active Compounds among Hydrogenated Isoindolylalkyl(alkylaryl-,aryl-)carboxylic Acids with Quinazoline Fragment that Modify the Carbohydrate Metabolism: Design, Synthesis and Modification

2019 ◽  
pp. 145-154
Author(s):  
Yulya Victorivna Martynenko ◽  
Oleksii Mykolayovich Antypenko ◽  
Оleksandr Anatolievich Brazhko ◽  
Irina Borisivna Labenska ◽  
Sergii Ivanovich Kovalenko
Keyword(s):  
Carbohydrate Metabolism ◽  
Carboxylic Acids ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Directed Search ◽  
Active Compounds ◽  
Design Synthesis

13C and1H NMR spectra of biologically active compounds. VII. Diastereomers of 2,2-dialkylspiro[cyclopropane-3,3′-indene]-1-carboxylic acids of the pyrethroid series

1988 ◽  
Vol 24 (4) ◽  
pp. 491-497
Author(s):  
L. M. Khalilov ◽  
V. S. Sultanova ◽  
E. V. Vasil'eva ◽  
L. V. Spirikhin ◽  
I. P. Baikova ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Nmr Spectra ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds

An efficient synthesis of 5-halo-6-trifluoromethylpyridine-3-carbonitriles and carboxylic acids

2017 ◽  
Vol 23 (6) ◽  
Author(s):  
Manjunath B. Channapur ◽  
Roger G. Hall ◽  
Mukul Lal ◽  
Sitaram Pal ◽  
Ashok S. Shyadligeri
Keyword(s):  
Carboxylic Acids ◽  
Biologically Active Compounds ◽  
Starting Material ◽  
Biologically Active ◽  
Pharmaceutical Chemistry ◽  
Efficient Synthesis ◽  
Active Compounds

AbstractTrifluoromethyl containing heterocycles are an integral part of many biologically active compounds in the agro and pharmaceutical chemistry. Herein, we report an efficient and concise three-step synthesis of 5-halo-6-trifluoromethylpyridine-3-carbonitriles from a trifluoroacetyl vinylogous enamine starting material. Hydrolysis furnishes the carboxylic acids.

scholarly journals Photoredox Synthesis of Arylhydroxylamines from Carboxylic Acids and Nitrosoarenes

Synthesis ◽  
2018 ◽  
Vol 50 (04) ◽  
pp. 821-830 ◽  
Author(s):  
Nadeem Sheikh ◽  
Daniele Leonori ◽  
Jacob Davies ◽  
Lucrezia Angelini ◽  
Mohammed Alkhalifah ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Late Stage ◽  
Building Blocks ◽  
Direct Conversion ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Alkyl Radicals ◽  
Radical Cascade ◽  
Cascade Processes

Hydroxylamines are found in biologically active compounds and serve as building blocks for the preparation of nitrogen-containing molecules. Here the direct conversion of carboxylic acids into the corresponding alkylhydroxylamines using organo-photoredox catalysis is reported. The process relies in the generation of alkyl radicals via photoinduced oxidation-decarboxylation and their following reaction with nitrosoarenes. We have successfully applied this method to the late-stage modification of complex and biologically active acids and applied it in novel radical cascade processes.

Nickel(0)-Catalyzed Linear-Selective Hydroarylation of Unactivated Alkenes and Styrenes with Arylboron Acids

2018 ◽  
Author(s):  
Honggui Lv ◽  
Li-Jun Xiao ◽  
Dongbing Zhao ◽  
Qi-Lin Zhou
Keyword(s):  
Butyric Acid ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Highly Efficient ◽  
Organoboronic Acids

Herein, we realized the first linear-selective hydroarylation of unactivated alkenes and styrenes with organoboronic acids by introducing directing groupon alkenes. Our method is highly efficient and scalable, and provides a modular route to assemble structurally diverse alkylarenes, especially for γ-aryl butyric acid derivatives, which have been widely utilized as chemical feedstocks to access multiple marketed drugs, and biologically active compounds.<br>

SOME DIRECTIONS IN THE MODIFICATION OF AZOLES

2020 ◽  
Vol 5 (443) ◽  
pp. 85-91
Author(s):  
Ibrayev M.K., ◽  
◽  
Takibayeva A.T., ◽  
Fazylov S.D., ◽  
Rakhimberlinova Zh.B., ◽  
...  
Keyword(s):  
13C Nmr Spectroscopy ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Synthesis Conditions ◽  
Alkaloid Cytisine ◽  
Azole Ring ◽  
Cyclic Compounds ◽  
New Compounds ◽  
Derivatives Of

This article presents studies on the targeted search for new derivatives of azoles, such as benzthiazole, 3,5-dimethylpyrazole, 1,3,4-oxadiazole-2-thione, 1,3,4-thiadiazole. The possibility of combining in one molecule of the azole ring with other cyclic compounds: the alkaloid cytisine, morpholine, furan and some arenes has been studied. To obtain new compounds, the reactions of bromination, acylation, and interaction with isothiocyanates were studied. Optimal synthesis conditions were studied for all reactions. It was found that the reaction of 4-bromo-3,5-dimethylpyrazole with isothiocyanates, in contrast to the previously written derivatives of anilines, takes a longer time and requires heating the reaction mixture. The combination of a pirasol fragment with halide substituents often results in an enhanced therapeutic effect. The synthesized 2-bromine-N-(6-rodanbenzo[d]thiazole-2-yl)acetamide, due to the alkylbromide group, is an important synth in the synthesis of new benzthiazole derivatives. Its derivatives combine in one molecule the rest of rhodanbenzthiazole with alkaloid cytisine and biogenic amine morpholine and are potentially biologically active compounds, since the molecule structure contains several pharmacophoric fragments: benzthiazole and alkaloid (amine) heterocycles, rhodane and urea groups. The mechanism of formation of 1,3,4-oxadiazole-2-tyons from hydrazides under action on them by carbon disulfide was studied and assumed. It was shown that dithiocarbamates in acidic medium decompose with the release of hydrogen sulfide and the formation of highly reactive isothiocyanate group. Then, intra-molecular cyclization occurs, with the formation of end products - 1,3,4-oxadiazole-2-thions. The structures of the synthesized compounds were studied by 1H and 13C NMR spectroscopy. All synthesized substances are potentially biologically active compounds, since they contain several pharmacophore fragments in their structure.

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