scholarly journals Synthesis of Cyclic and Acyclic Pyrimidine Nucleosides Analogues with Anticipated Antiviral Activity

2018 ◽  
pp. 401-406
Author(s):  
Mohamed F. El-Shehry ◽  
Emad M. El Telbani ◽  
Mohamed I. Hegab
Keyword(s):  
Antiviral Activity ◽  
Pyrimidine Nucleosides

Antiviral activity of certain substituted purine and pyrimidine nucleosides

1969 ◽  
Vol 25 (1) ◽  
pp. 98-100 ◽  
Author(s):  
A. R. Diwan ◽  
R. K. Robins ◽  
W. H. Prusoff
Keyword(s):  
Antiviral Activity ◽  
Pyrimidine Nucleosides

Synthesis and Antiviral Activity of 5′-O-(Substituted) Sulfamoyl Pyrimidine Nucleosides

1989 ◽  
Vol 322 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Julia Castro-Pichel ◽  
M. Teresa García-López ◽  
Federico G. de Las Heras ◽  
Rosario Herranz ◽  
Concepción Pérez ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Pyrimidine Nucleosides

scholarly journals Selective Inhibition of Enterovirus A Species Members’ Reproduction by Furano[2, 3-d ]pyrimidine Nucleosides Revealed by Antiviral Activity Profiling against (+)ssRNA Viruses

2018 ◽  
Vol 3 (8) ◽  
pp. 2321-2325 ◽  
Author(s):  
Liubov I. Kozlovskaya ◽  
Anastasia D. Golinets ◽  
Anastasia A. Eletskaya ◽  
Alexey A. Orlov ◽  
Vladimir A. Palyulin ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Selective Inhibition ◽  
Pyrimidine Nucleosides ◽  
Activity Profiling

scholarly journals Antiviral Activity of Bicyclic Pyrimidine Nucleosides

1995 ◽  
Vol 6 (6) ◽  
pp. 371-378 ◽  
Author(s):  
D. Loakes ◽  
D. M. Brown ◽  
N. Mahmood ◽  
J. Balzarini ◽  
E. De Clercq
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hydrogen Bonding ◽  
Herpes Simplex ◽  
Antiviral Activity ◽  
Significant Activity ◽  
Varicella Zoster ◽  
Pyrimidine Nucleosides ◽  
Immunodeficiency Virus ◽  
Simplex Virus

A number of pyrimidine nucleosides, which may show two hydrogen bonding modes, have been prepared and tested for antiviral activity against a series of viruses. Whilst none of the compounds described showed significant activity against human immunodeficiency virus (HIV), the bicyclic 2′-deoxynucleoside, [2], derived from the base 6H,8H-3,4-dihydropyrimido[4,5-c][1,2]oxazin-7-one, was shown to inhibit herpes simplex virus type 1 (HSV-1) at similar concentrations as BVDU1 and ACV. Compounds 13, 6-(2-deoxyribofuranosyl)-6H,8H-2-methyl-3,4-dihydropyrimido[4,5-c][1,2]oxazin-7-one, and 14, N4-hydroxy-5-(2-chloroethyl)-2′-deoxyuridine, were as active as ACV against varicella-zoster virus (VZV).

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