scholarly journals SURFACE MODIFIED TITANIUM DIOXIDE/POLY(LACTIC ACID) NANOCOMPOSITE FILMS FOR TISSUE ENGINEERING

2021 ◽  
Author(s):  
Şükran Melda ESKİTOROS TOĞAY ◽  
Ulya TOKGOZ
Keyword(s):  
Tissue Engineering ◽  
Titanium Dioxide ◽  
Lactic Acid ◽  
Nanocomposite Films ◽  
Poly Lactic Acid ◽  
Surface Modified

Strong and ductile poly(lactic acid) nanocomposite films reinforced with alkylated graphene nanosheets

2015 ◽  
Vol 264 ◽  
pp. 538-546 ◽  
Author(s):  
Li Zhang ◽  
Yinfeng Li ◽  
Huanhuan Wang ◽  
Yadong Qiao ◽  
Jinzhou Chen ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Graphene Nanosheets ◽  
Nanocomposite Films ◽  
Poly Lactic Acid

Development of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering

2021 ◽  
pp. 002199832098856
Author(s):  
Marcela Piassi Bernardo ◽  
Bruna Cristina Rodrigues da Silva ◽  
Luiz Henrique Capparelli Mattoso
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Poly Lactic Acid ◽  
Scanning Calorimetry ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed

Injured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft.

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