scholarly journals Equilibrium in the System of Glauconite – Aqueous Solution of Cefepime Hydrochloride

2019 ◽  
Vol 21 (4) ◽  
pp. 528-533
Author(s):  
Tatiana A. Krysanova ◽  
Diana L. Kotova ◽  
Mohammed T. Bestoon
Keyword(s):  
New York ◽  
Degradation Products ◽  
In Vitro Release ◽  
Vitamin B1 ◽  
Chemical Properties ◽  
Alkaline Treatment ◽  
Voronezh Anteclise ◽  
Medicinal Substances ◽  
Physical And Chemical

The patterns of immobilization of cefepime hydrochloride on glauconite at a temperature of 295 K are established. The isotherm of sorption of cefepime hydrochloride from dilute solutions is described using the Langmuir theory. The values of the maximum capacity of the monolayer and the coefficient of the sorption equilibrium for cefepime hydrochloride are calculated. It is revealed that the monolayer binding of the antibiotic to glauconite is the result of an equivalent exchange with the extra-frame cations of the sorbent. The polymolecular nature of the sorption may be due to the formation of cefepime hydrochloride associates due to hydrogen bonds.           REFERENCES Кevadiya Bravesh D., Ghanshyam V. Joshi, Hasmukh A. Patel, et al. Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6. Journal of Biomaterials Aplications, 2010, v. 25(2), pp. 161-177. DOI: https://doi.org/10.1177/0885328209344003  Farıas T., Rabdel Ruiz-Salvador A., Lya Velazco, et al. Preparation of natural zeolitic supports for potential biomedical applications. Materials Chemistry and Physics, 2009, v. 118, pp. 322–328. doi: https://doi.org/10.1016/j.matchemphys.2009.07.054 Chernova R.K., Venig S.B., Naumova G.N., et al. Sorption of tetracycline and its degradation products by glauconite. Scientific almanac, 2015,  7, pp. 930-934. doi: https://doi.org/0.17117/na.2015.07.930 Vlasova N.N. Interaction of highly dispersed silica with some medicinal substances. Surface, 2016, v. 8(23), pp. 236-247. DOI: https://doi.org/10.15407/surface.2016.08.236  Stavinskaya O.N., Laguta I.V. The properties of silica-gelatin composites. Russian Journal of Physical Chemistry A, 2010, v. 84(6), pp. 1045-1048. doi: https://doi.org/10.1134/s0036024410060270  Fiziko-khimicheskiye i mediko-biologicheskiye svoystva prirodnykh zeolitov [Physicochemical and biomedical properties of natural zeolites] / Ed. by Z.V. Belousova. Novosibirsk, Izd-vo un-ta geologii i geofiziki Publ., 1990, 70 p. (in Russ.) Breck D. W. Zeolite molecular seves: Structure, Chemistry and Use. Wiley—Interscience, New York, 1974, 771 p. Egorov N.S. Osnovy ucheniya ob antibiotikakh [Fundamentals of the doctrine of antibiotics]. Moscow, Nauka Publ., 2004, 528 p. (in Russ.) Yakovlev P.V. Ciprofloxacin in the treatment and prophylaxis of surgikal infections. Antibiotiki i khimioterapiya, 1999, v. 44(7), pp. 32-37. (in Russ.) Zhabin A.V., Savko A.D. Glaukonity Voronezhskoy anteklizy. Ocherki po regionalnoy geologii [Glauconites of the Voronezh anteclise. Essays on regional Ggeology]. Saratov, Nauka Publ., 2008, pp. 48-56. (in Russ.) Novikova L.A., Belchinskay L.I., Krupskaya V.V., et al. Effect of acid and alkaline treatment on physical and chemical properties of natural glauconite surface. Sorption and Chromatographic Processes, 2015, v. 15(5), pp. 730-740. Available at: https://doi.org/10.17308/sorpchrom.2015.15/327 (accessed 23.10.2019) (in Russ.) Polyanskiy N.G.. Gorbunov V.G.. Polyanskaya N.L. Research methods of ion exchangers. Moscow, Khimiya Publ., 1976, 208 p. (in Russ.) Nakanisi K. Infrared spectroscopy and structure of organic compounds. Moscow, Mir Publ., 1987, 220 p. (in Russ.) Bekker Yu. Spektroskopiya [Spectroscopy]. Moscow, Tekhnosfera Publ., 2009, 528 p. (in Russ.) Sing K.S.W., Everett D.H., Haul R.A.W. Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity. Pure and Applied Chemistry, 1985, v. 57(4), pp. 603-619. doi: https://doi.org/10.1351/pac198557040603 Kotova D.L., Fam Tkhi Gam, Krysanova T.A., et al. Description of pyridoxine hydrochloride sorption isotherm on clinoptilolite tuff. Sorption and Chromatographic Processes, 2014, v. 14(4), pp. 572-577. Available at: http:// www.sorpchrom.vsu.ru/articles /20140404.pdf (accessed 23.10.2019) (in Russ.) Langmuir I. The Constitution and fundamental properties of solids and liquids. Am. Chem. Soc., 1917, v. 39(9), pp. 1848-1906. doi: https://doi.org/10.1021/ja02254a006 Freundlich H.M.F. Over the adsorption in solution. Phys. Chem., 1906, v. 57, pp. 385-447. Redlich O.A., Peterson D.L. Useful adsorption isotherm. Phys. Chem., 1959, v. 63(6), pp. 1024-1025. doi: https://doi.org/10.1021/j150576a611  Pyul'man B. Intermolecular interaction: from diatomic molecules to biopolymers, Moscow, Мir Publ., 1981, 592 p. (in Russ.)

scholarly journals Physicochemical Characteristics of Arginine Enriched NaF Varnish: An In Vitro Study

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2998
Author(s):  
Mohammed Nadeem Bijle ◽  
Manikandan Ekambaram ◽  
Edward Lo ◽  
Cynthia Yiu
Keyword(s):  
Molecular Dynamics ◽  
Physical Properties ◽  
Artificial Saliva ◽  
Chemical Properties ◽  
In Vitro Study ◽  
Physicochemical Characteristics ◽  
Vitro Study ◽  
Physical And Chemical ◽  
Stable Matrix

The in vitro study objectives were to investigate the effect of arginine (Arg) incorporation in a 5% sodium fluoride (NaF) varnish on its physical and chemical properties including F/Arg release. Six experimental formulations were prepared with L-arginine (L-Arg) and L-arginine monohydrochloride at 2%, 4%, and 8% w/v in a 5% NaF varnish, which served as a control. The varnishes were subjected to assessments for adhesion, viscosity, and NaF extraction. Molecular dynamics were simulated to identify post-dynamics total energy for NaF=Arg/Arg>NaF/Arg<NaF concentrations. The Arg/F varnish release profiles were determined in polyacrylic lactate buffer (pH-4.5; 7 days) and artificial saliva (pH-7; 1 h, 24 h, and 12 weeks). Incorporation of L-Arg in NaF varnish significantly influences physical properties ameliorating retention (p < 0.001). L-Arg in NaF varnish institutes the Arg-F complex. Molecular dynamics suggests that NaF>Arg concentration denotes the stabilized environment compared to NaF<Arg (p < 0.001). The 2% Arg-NaF exhibits periodic perennial Arg/F release and shows significantly higher integrated mean F release than NaF (p < 0.001). Incorporating 2% L-arginine in 5% NaF varnish improves its physical properties and renders a stable matrix with enduring higher F/Arg release than control.

scholarly journals Formulation and evaluation of bi-layer floating tablets of ziprasidone HCl and trihexyphenidyl HCl

2011 ◽  
Vol 47 (3) ◽  
pp. 545-553 ◽  
Author(s):  
Sathis Kumar Dinakaran ◽  
Santhos Kumar ◽  
David Banji ◽  
Harani Avasarala ◽  
Venkateshwar Rao
Keyword(s):  
Sustained Release ◽  
In Vitro Release ◽  
Chemical Properties ◽  
Matrix Tablets ◽  
In Vitro Dissolution ◽  
Floating Tablets ◽  
Ir Studies ◽  
Weight Variation ◽  
The Matrix

The purpose of this research study was to establish ziprasidone HCl NR 40 mg and trihexyphenidyl HCl SR 4mg in the form of bi-layer sustained release floating tablets. The tablets were prepared using sodium HPMC K4M / HPMC K15M as bio-adhesive polymers and sodium bicarbonate acting as a floating layer. Tablets were evaluated based on different parameters such as thickness, hardness, friability, weight variation, in vitro dissolution studies, content of active ingredient and IR studies. The physico-chemical properties of the finished product complied with the specifications. In vitro release from the formulation was studied as per the USP XXIII dissolution procedure. The formulations gave a normal release effect followed by sustained release for 12 h which indicates bimodal release of ziprasidone HCl from the matrix tablets. The data obtained was fitted to Peppas models. Analysis of n values of the Korsmeyer equation indicated that the drug release involved non-diffusional mechanisms. By the present study, it can be concluded that bi-layer tablets of ziprasidone HCl and trihexyphenidyl HCl will be a useful strategy for extending the metabolism and improving the bioavailability of Ziprasidone HCl and Trihexyphenidyl HCl.

Montmorillonite-Alginate Nanocomposites as a Drug Delivery System: Intercalation and In Vitro Release of Vitamin B1 and Vitamin B6

2009 ◽  
Vol 25 (2) ◽  
pp. 161-177 ◽  
Author(s):  
Bhavesh D. Kevadiya ◽  
Ghanshyam V. Joshi ◽  
Hasmukh A. Patel ◽  
Pravin G. Ingole ◽  
Haresh M. Mody ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Vitamin B6 ◽  
In Vitro Release ◽  
Vitamin B1 ◽  
Vitro Release

scholarly journals Co-Crystals of Resveratrol and Polydatin with L-Proline: Crystal Structures, Dissolution Properties, and In Vitro Cytotoxicities

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5722
Author(s):  
Yijie Lou ◽  
Kaxi Yu ◽  
Xiajun Wu ◽  
Zhaojun Wang ◽  
Yusheng Cui ◽  
...  
Keyword(s):  
Cell Line ◽  
Chemical Properties ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Hek 293 ◽  
Dissolution Properties ◽  
Diphenyltetrazolium Bromide ◽  
Water Ph ◽  
Physical And Chemical

Resveratrol (RSV) and polydatin (PD) have been widely used to treat several chronic diseases, such as atherosclerosis, pulmonary fibrosis, and diabetes, among several others. However, their low solubility hinders their further applications. In this work, we show that the solubility of PD can be boosted via its co-crystallization with L-proline (L-Pro). Two different phases of co-crystals, namely the RSV-L-Pro (RSV:L-Pro = 1:2) and PD-L-Pro (PD:L-Pro = 1: 3), have been prepared and characterized. As compared to the pristine RSV and PD, the solubility and dissolution rates of PD-L-Pro in water (pH 7.0) exhibited a 15.8% increase, whereas those of RSV-L-Pro exhibited a 13.8% decrease. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay of pristine RSV, PD, RSV-L-Pro, and PD-L-Pro against lung cancer cell line A549 and human embryonic kidney cell line HEK-293 indicated that both compounds showed obvious cytotoxicity against A549, but significantly reduced cytotoxicity against HEK-293, with PD/PD-L-Pro further exhibiting better biological safety than that of RSV/RSV-L-Pro. This work demonstrated that the readily available and biocompatible L-Pro can be a promising adjuvant to optimize the physical and chemical properties of RSV and PD to improve their pharmacokinetics.

Abstract 230: Lipoprotein X Causes Renal Disease in LCAT Deficiency

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Edward B Neufeld ◽  
Alice Ossoli ◽  
Seth G Thacker ◽  
Boris Vaisman ◽  
Milton Pryor ◽  
...  
Keyword(s):  
Renal Disease ◽  
Plasma Clearance ◽  
Mesangial Cells ◽  
Chemical Properties ◽  
Low Hdl ◽  
Lcat Deficiency ◽  
Physical And Chemical ◽  
Dependent Pathway

Familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is characterized by low HDL, accumulation of an abnormal cholesterol-rich multilamellar particle called lipoprotein-X (LpX) in plasma, and renal disease. The aim of our study was to determine if LpX is nephrotoxic and to gain insight into the pathogenesis of FLD renal disease. We administered a synthetic LpX, nearly identical to endogenous LpX in its physical, and chemical properties, to wild-type and Lcat -/- mice. Our in vitro and in vivo studies demonstrated an apoA-I and LCAT-dependent pathway for LpX conversion to HDL-like particles, which likely mediates normal plasma clearance of LpX. Plasma clearance of exogenous LpX was markedly delayed in Lcat -/- mice, which have low HDL but only minimal amounts of endogenous LpX and do not spontaneously develop renal disease. Chronically administered exogenous LpX deposited in all renal glomerular cellular and matrical compartments of Lcat -/- mice, and induced proteinuria and nephrotoxic gene changes, as well as all of the hallmarks of FLD renal disease as assessed by histological, TEM, and SEM analyses. Extensive in vivo EM studies revealed LpX uptake by macropinocytosis into mouse glomerular endothelial cells, podocytes, and mesangial cells and delivery to lysosomes, where it was degraded. Endocytosed LpX appeared to be degraded by both human podocyte and mesangial cell lysosomal PLA 2 and induced podocyte secretion of pro-inflammatory IL-6 in vitro and renal Cxl10 expression in Lcat -/- mice. In conclusion, LpX is a nephrotoxic particle that in the absence of LCAT induces all of the histological and functional hallmarks of FLD and hence may serve as a biomarker for monitoring recombinant LCAT therapy. In addition, our studies suggest that LpX-induced loss of endothelial barrier function and release of cytokines by renal glomerular cells likely plays a role in the initiation and progression of FLD nephrosis.

In vitro Degradation Analysis of 3D-architectured Gelatin-based Hydrogels

MRS Advances ◽  
2019 ◽  
Vol 5 (12-13) ◽  
pp. 633-642
Author(s):  
Jun Hon Pang ◽  
Christian Wischke ◽  
Andreas Lendlein
Keyword(s):  
Rational Design ◽  
Loss Modulus ◽  
Hydrolytic Stability ◽  
Hydrolytic Degradation ◽  
Chemical Properties ◽  
In Vitro Models ◽  
Polypeptide Backbone ◽  
Tan Δ ◽  
Physical And Chemical

ABSTRACT:Multifunctional biopolymer-based materials are promising candidates for next generation regenerative biomaterials. Understanding the degradation behavior of biomaterials is vital for ensuring biological safety, as well as for better control of degradation properties based on rational design of a material’s physical and chemical characteristics. In this study, we decipher the degradation of a hydrogel prepared from gelatin and lysine diisocyanate ethyl ester (LDI) using in vitro models, which simulate hydrolytic, oxidative and enzymatic degradation (collagenase). Gravimetrical, morphological, mechanical and chemical properties were evaluated. Notably, the hydrogels were relatively resistant to hydrolytic degradation, but degraded rapidly within 21 days (>95% mass loss) under oxidative and collagenase degradation. Oxidative and collagenase degradation rapidly decreased the storage and loss modulus of the hydrogels, and slightly increased their viscous component (tan δ). For each degradation condition, the results suggest different possible degradation pathways associated to the gelatin polypeptide backbone, urea linkages and ester groups. The primary degradation mechanisms for the investigated gelatin based hydrogels are oxidative and enzymatic in nature. The relative hydrolytic stability of the hydrogels should ensure minimal degradation during storage and handling prior to application in surgical theatres.

scholarly journals DESIGN AND CHARACTERISATION OF TRANSDERMAL PATCHES OF PHENFORMIN HYDROCHLORIDE

2017 ◽  
Vol 9 (6) ◽  
pp. 90
Author(s):  
Pratik Swarup Das ◽  
Puja Saha
Keyword(s):  
Drug Release ◽  
Diffusion Mechanism ◽  
Skin Irritation ◽  
In Vitro Release ◽  
Chemical Properties ◽  
In Vitro Dissolution ◽  
Release Mechanism ◽  
Transdermal Patches ◽  
The Matrix

Objective: In present work was designed to develop suitable transdermal matrix patches of Phenformin hydrochloride using various hydrophilic (HPMC) and hydrophobic (EUDRAGID) polymers as matrix formers.Methods: Transdermal patches containing Phenformin hydrochloride were prepared by the solvent casting evaporation technique.Results: Revealed that prepared patches showed good physical characteristics, no drug-polymer interaction and no skin irritation was observed. The in vitro release study revealed that F3 formulation showed maximum release in 24 h. Formulation F3 was subjected for accelerated stability studies. The F3 formulation was found to be stable as there was no drastic change in the Physico-chemical properties of the patches, which was also confirmed by FTIR.Conclusion: Thus conclusion can be made that stable transdermal patches of Phenformin hydrochloride has been developed. F1, F2, F3, F4 formulations showed highest cumulative percentage drug release of 98.13%, 95.50%, 98.65%, 97.21% were obtained during in vitro drug release studies after 24 h. The release of Phenformin hydrochloride appears to be dependent on lipophilicity of the matrix. Moderately lipophillic matrices showed best release. The predominant release mechanism of drug through the fabricated matrices was believed to be by diffusion mechanism. Based upon the in vitro dissolution data the F3 formulation was concluded as optimized formulation.

scholarly journals The novel method to reduce the silica content in lignin recovered from black liquor originating from rice straw

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Nghi H. Do ◽  
Hieu H. Pham ◽  
Tan M. Le ◽  
Jeroen Lauwaert ◽  
Ludo Diels ◽  
...  
Keyword(s):  
Rice Straw ◽  
Black Liquor ◽  
Chemical Properties ◽  
Alkaline Treatment ◽  
Pilot Scale ◽  
Silica Content ◽  
Silica Removal ◽  
High Silica ◽  
Novel Method ◽  
Physical And Chemical

AbstractDifficulties in the production of lignin from rice straw because of high silica content in the recovered lignin reduce its recovery yield and applications as bio-fuel and aromatic chemicals. Therefore, the objective of this study is to develop a novel method to reduce the silica content in lignin from rice straw more effectively and selectively. The method is established by monitoring the precipitation behavior as well as the chemical structure of precipitate by single-stage acidification at different pH values of black liquor collected from the alkaline treatment of rice straw. The result illustrates the significant influence of pH on the physical and chemical properties of the precipitate and the supernatant. The simple two-step acidification of the black liquor at pilot-scale by sulfuric acid 20w/v% is applied to recover lignin at pH 9 and pH 3 and gives a percentage of silica removal as high as 94.38%. Following the developed process, the high-quality lignin could be produced from abundant rice straw at the industrial-scale.

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