scholarly journals Tumor suppressor maspin as a modulator of host immune response to cancer

2015 ◽  
Vol 15 (4) ◽  
Author(s):  
Sijana H. Dzinic ◽  
Maria M. Bernardo ◽  
Daniel S.M. Oliveira ◽  
Marian Wahba ◽  
Wael Sakr ◽  
...  
Keyword(s):  
Immune Response ◽  
Tumor Suppressor ◽  
Host Immune Response ◽  
Immune Response To Cancer

scholarly journals PTEN functions as a melanoma tumor suppressor by promoting host immune response

Oncogene ◽  
2013 ◽  
Vol 33 (38) ◽  
pp. 4632-4642 ◽  
Author(s):  
Y Dong ◽  
J-AE Richards ◽  
R Gupta ◽  
P P Aung ◽  
A Emley ◽  
...  
Keyword(s):  
Immune Response ◽  
Tumor Suppressor ◽  
Host Immune Response ◽  
Melanoma Tumor

scholarly journals Human Norovirus Proteins: Implications in the Replicative Cycle, Pathogenesis, and the Host Immune Response

2020 ◽  
Vol 11 ◽  
Author(s):  
Claudia P. Campillay-Véliz ◽  
Jonatan J. Carvajal ◽  
Andrea M. Avellaneda ◽  
Darling Escobar ◽  
Camila Covián ◽  
...  
Keyword(s):  
Immune Response ◽  
Host Immune Response ◽  
Human Norovirus ◽  
Replicative Cycle

scholarly journals H-Ras gene takes part to the host immune response to COVID-19

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Salvatore Sciacchitano ◽  
Andrea Sacconi ◽  
Claudia De Vitis ◽  
Giovanni Blandino ◽  
Giulia Piaggio ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune Response ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Severe Disease ◽  
Host Immune Response ◽  
Severe Form ◽  
Ras Gene ◽  
Peripheral Blood Mononuclear ◽  
Ras Genes

AbstractRas gene family members play a relevant role in cancer, especially when they are mutated. However, they may play additional roles in other conditions beside cancer. We performed gene expression analysis using the NanoString PanCancer IO 360 panel in the peripheral blood mononuclear cell (PBMC) of six COVID-19 patients and we found that H-Ras gene was significantly upregulated, while both K-Ras and N-Ras genes were downregulated. In particular, H-Ras gene upregulation was more evident in COVID-19 patients with a more severe disease. We compared our results with those obtained by analyzing two different and independent datasets, including a total of 53 COVID-19 patients, in which the gene expression analysis was performed using the Immunology_V2 panel. Comparative analysis of the H-Ras gene expression in these patients confirmed our preliminary results. In both of them, in fact, we were able to confirm the upregulation of the expression of the H-Ras gene. The exact role of this specific upregulation of the H-Ras gene in response to SARS-CoV-2 infection and its possible role in cancer still remains to be elucidated. In conclusion, H-Ras gene participates to the host immune response to SARS-CoV-2 virus infection, especially in patients affected by the most severe form of the COVID-19.

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