scholarly journals Ocular manifestation of rheumatoid arthritis-different forms and frequency

2010 ◽  
Vol 10 (4) ◽  
pp. 323-327 ◽  
Author(s):  
Gordana Zlatanović ◽  
Dragan Veselinović ◽  
Sonja Cekić ◽  
Maja Živković ◽  
Jasmina Đorđević- Jocić ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Keratoconjunctivitis Sicca ◽  
Anterior Segment ◽  
Retinal Vasculitis ◽  
Applanation Tonometry ◽  
Ocular Involvement ◽  
Ocular Manifestation ◽  
Posterior Scleritis ◽  
Ocular Manifestations ◽  
Systemic Inflammatory Disease

Rheumatoid arthritis (RA) is a systemic inflammatory disease associated with a number of extra-articular organ manifestations. Ocular manifestations involved with RA are keratoconjunctivitis sicca, episcleritis, scleritis, corneal changes, and retinal vasculitus. The etiopathogenesis of this autoimmune disorder is still unknown. Aim of our study was to present different ocular manifestations of RA and their frequency. We have examined 691 patient with the diagnoses of RA. All examined patients were in I or II stage of the disease according to criteria of The American College of Rheumatology. Ophthalmological exam obtained: visual acuity by Snellen sings, biomicroscopy of anterior segment, Schirmer test, tear break-up time (BUT), applanation tonometry and indirect ophthalmoscopy. In all patients with retinal vasculitis fotofundus and in indicated cases fluorescein angiography was preformed. The most common manifestation of ocular involvement was keratoconjunctivitis sicca. Episcleritis was diagnosed in 5.06% patients with RA, while scleritis was present in 2.06% of patients. Diffuse scleritis was present in one patient, while nodular was present in 13 patients. There were no patients with posterior or necrotizing scleritis among examined patients. Sclerosing keratitis was diagnosed in 11 female patients. It is characterized with peripheral thickening and opacification of the stroma adjacent to the site of inflammation. Posterior scleritis or scleromalacia of cornea was not present in our patients, because all of them were in I or II stage of disease. Retinal vasculitis was present in three patients, two male and one female patient (0.45%). Ocular manifestation was present in 27.2% of patients. Women were more affected.

scholarly journals Vasculitis Retinae- A Rare Presentation of SLE

2019 ◽  
Vol 10 (2) ◽  
pp. 179-182
Author(s):  
Sanwar Hossain ◽  
Titus Leonard Guda ◽  
Forhad Chowdhury ◽  
Md Somir Hossain ◽  
Mehran Hossain ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Keratoconjunctivitis Sicca ◽  
Normal Population ◽  
Systemic Disease ◽  
Disease Onset ◽  
Retinal Vasculitis ◽  
Ocular Involvement ◽  
Rare Presentation ◽  
Medical College ◽  
Ocular Manifestations

Systemic lupus erythematosus (SLE) is a rare complex autoimmune disease characterized by autoantibody  formation against double strand DNA and antinuclear antibody (ANA), complement activation, and  deposition of immune complexes in tissues and organs. In normal population only 0.03% suffer from SLE,  among them 90% are female between the age of 20 to 30 yrs. SLE can involve any region of the visual  system. Although ocular manifestations are not part of the classification criteria for SLE but retinal involvement is the most common intraocular lesion observed in up to one-third of SLE patients. The most  common extra ocular lesion is keratoconjunctivitis sicca. Ocular manifestations are rarely reported at the  time of disease onset, but are usually associated with active generalized systemic disease. Due to low  frequency of SLE and only one third of them have ocular involvement, so reports about retinal vasculitis  are very rare. But fortunately a case of Vasculitis retinae due to SLE was admitted in Anwer Khan Modern  Medical College & Hospital on 04/12/2018 Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 179-182

scholarly journals AB0162 OCULAR MANIFESTATIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1108.1-1108
Author(s):  
D. Monova ◽  
S. Monov ◽  
R. Shumnalieva ◽  
D. Dimova ◽  
M. Sotirova
Keyword(s):  
Rheumatoid Arthritis ◽  
Intraocular Pressure ◽  
Disease Duration ◽  
Keratoconjunctivitis Sicca ◽  
Retinal Vasculitis ◽  
Standard Test ◽  
Systemic Autoimmune Disease ◽  
Ophthalmological Examination ◽  
Schirmer’S Test ◽  
Ocular Symptoms

Background:Rheumatoid arthritis (RA) is the most common systemic autoimmune disease and is associated with a number of extra-articular organ manifestations, including ocular complications.Objectives:The aim of this study is to evaluate the frequency and characteristics of ocular manifestation in patients with rheumatoid arthritis (RA).Methods:The study involved 87 patients with RA. All the study subjects underwent complete ophthalmological examination involving visual acuity assessment, examination of anterior and posterior eye segments, Schirmer’s test, diameter and mobility of pupils, as well as eyeball mobility assessment of intraocular pressure. Data regarding age, gender, disease duration, age at diagnosis, systemic corticosteroid use, blood pressure, ocular symptoms and detailed ophthalmic history were recorded. The presence of rheumatoid factor in serum was evaluated by standard test methods based on principle of agglutination. All patients were seropositive.Results:87 patients (26 male, 59 female, mean age 45,6 ± 13,1 years; mean disease duration 7,4 ± 6,2 years) with RA were enrolled in this study. 31 (35,63 %) of them had no ocular symptoms. Among the patients with ocular symptoms, 39 (69,64 %) complained of decreased vision, 33 (58,93 %) - of dry eye, 32 (57,14 %) - of burning, 29 (51,78 %) -photophobia, 28 (50 %) - of gritty sensation, 27 (48,21 %) - of itching, 18 (32,14 %) - of redness, 13 (23,21 %) - of ocular pain, 3 (5,36 %) - of floaters. Ophthalmological examination revealed higher incidence of the following abnormalities in the study group: myopic astigmatism - in 10 (5,74 %) eyes, vascular abnormalities within fundus - in 22 (12,64 %) eyes, increased intraocular pressure (> 21 mm Hg) - in 11 (6,32 %) eyes. Mean IOP values were 17,34 ± 5,12 mm Hg. In 48 eyes Schirmer’s test results were below 10 mm, and in 18 eyes - below 5 mm. Keratoconjunctivitis sicca was present in 31 (35,63 %) of all patients. Episcleritis was diagnosed in 4 patients (4,6 %), scleritis – in 3 (3,45 %). Retinal vasculitis was present in 2 (2,3 %) patients and involves veins and arteries peripheral branches. Lens opacity was found in 13 (14,94 %) patients (21 eyes), mostly in the form of posterior subcapsular cataract (in 16 eyes) and nuclear cataract (in 5 eyes). The mean age of patients with cataracts was 52,3 ± 14,2 years. 13 of the patients with cataracts were either currently taking or had previously taken systemic corticosteroids.Conclusion:In patients with RA numerous abnormalities within the vision of organ may be found. Ocular symptoms are relatively common complications of RA, and may result in irreversible changes in the organ of vision. Regular ophthalmological examinations are essential among the patients with RA.Disclosure of Interests:None declared

scholarly journals Ocular manifestations in HIV/AIDS cases in Nepal

1970 ◽  
Vol 2 (1) ◽  
pp. 45-50 ◽  
Author(s):  
G Lamichhane ◽  
DN Shah ◽  
S Sharma ◽  
M Chaudhary
Keyword(s):  
Herpes Zoster ◽  
Anterior Uveitis ◽  
Anterior Segment ◽  
Ocular Involvement ◽  
Herpes Zoster Ophthalmicus ◽  
Cmv Retinitis ◽  
Ocular Manifestations ◽  
Keywords Hiv ◽  
Number Of Patients ◽  
Hiv Aids

Background: A significant number of patients with HIV/AIDS can have ocular manifestations. Almost every structure in the eyes can be affected in this condition. Objective: To study various ocular manifestations in the cases known to be infected with HIV. Materials and methods: A cross-sectional descriptive study was carried out including 117 subjects positive for HIV using the purposive sampling method. Their demographic pattern and ocular findings were studied. Findings were recorded in the pro forma developed for the study. Statistics: SPSS ver 14.0 was used for data analysis. The p value of <0.05 was considered as significant. Results: A total of 117 HIV infected cases were included in this study. Among them, 76 (64.95 %) were male and 41 (35.05 %) female. The mean age of the subjects was 30.04 ± 11.32 years. The duration of HIV detection ranged from 1-5 years. Ocular complaints were present in 26.49 % of the subjects. Ocular manifestations were present in 56 % of the patients with complaints and in 27.3 % of asymptomatic patients. Ocular involvement was seen in 55 (47 %) patients. The common anterior segment findings were herpes zoster ophthalmicus (4.27 %), anterior uveitis (2.56 %), blepharitis (2.56 %) and conjunctivitis (1.7 %), whereas HIV retinopathy (19.6 %), CMV retinitis (5.1 %), ocular toxoplasmosis (2.5 %) and presumed ocular tuberculosis (0.85 %) were common posterior segment findings. Conclusion: Herpes zoster ophthalmicus, anterior uveitis, HIV retinopathy and CMV retinitis are common ocular manifestations associated with HIV infections. Keywords: HIV/AIDS; anterior and posterior segments; ocular involvement DOI: 10.3126/nepjoph.v2i1.3704 Nep J Oph 2010;2(1) 45-50

scholarly journals Ocular Manifestations of Systemic Lupus Erythematosus: A Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Neal V. Palejwala ◽  
Harpreet S. Walia ◽  
Steven Yeh
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Keratoconjunctivitis Sicca ◽  
Treatment Options ◽  
Retinal Vasculitis ◽  
Organ Damage ◽  
High Dose ◽  
Systemic Lupus ◽  
Ocular Manifestations ◽  
Dose Oral

About one-third of patients suffering from systemic lupus erythematosus have ocular manifestations. The most common manifestation is keratoconjunctivitis sicca. The most vision threatening are retinal vasculitis and optic neuritis/neuropathy. Prompt diagnosis and treatment of eye disease is paramount as they are often associated with high levels of systemic inflammation and end-organ damage. Initial management with high-dose oral or IV corticosteroids is often necessary. Multiple “steroid-sparing” treatment options exist with the most recently studied being biologic agents.

scholarly journals Eye and Rheumatology

2021 ◽  
pp. 419-428
Author(s):  
Abdullah A Al-ghamdi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Juvenile Idiopathic Arthritis ◽  
Lupus Erythematosus ◽  
Visual Loss ◽  
Ocular Involvement ◽  
Ocular Manifestation ◽  
Systemic Lupus ◽  
Systemic Involvement ◽  
Rheumatologic Diseases ◽  
Ocular Manifestations

AbstractThe ocular involvement in rheumatology can be in a wide variety; it ranges from simple episcleritis to significant visual loss. Early detection followed by appropriate management can reserve vision. Ophthalmic involvement may occur in all of the rheumatic disorders. Ocular manifestation may be a presenting sign in some disorders, as in juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), and Sjogren’s syndrome (SjS), or can be a presenting sign with the systemic involvement as in systemic lupus erythematosus (SLE), polyarteritis nodosa (PAN), granulomatosis with polyangiitis (GPA), and systemic sclerosis. Thus ocular manifestations in rheumatologic diseases (Table 19.1) can be the link in approaching the diagnosis.

scholarly journals A prevalence study of ocular manifestations in HIV positive patients on highly active anti-retroviral therapy

2019 ◽  
Vol 6 (7) ◽  
pp. 2950
Author(s):  
Hemal S. Hothi ◽  
Neepa R. Gohil ◽  
Nilesh V. Parekh ◽  
Sagar S. Patel
Keyword(s):  
Hiv Infection ◽  
Systemic Disease ◽  
Clinical Stage ◽  
Anterior Segment ◽  
Posterior Segment ◽  
Hiv Positive ◽  
Ocular Manifestation ◽  
Ocular Manifestations ◽  
Ocular Symptoms ◽  
Cell Counts

Background: Among 40 million cases worldwide, 50-75% of patients have at least one ocular manifestation in their lifetime. Many of ocular infections are treatable with therapeutic agents. Ocular manifestations invariably reflect systemic disease and can be the initial manifestations of HIV in many cases. Understanding of ocular sequel of HIV infection can lead to the early diagnosis and effective treatment. This study emphasizes on the need of developing a specific ophthalmic examination for the management of ocular manifestations in HIV infected patients.Methods: Cross sectional and observational study of 100 HIV positive participants on HAART were done irrespective of presence or absence of ocular symptoms. Participants were examined for complete ocular examination. Prevalence find out using chi-square test, find p values and ensuring statistical significance.Results: In our study, prevalence of ocular manifestation in HIV positive patients receiving HAART was 39%. Out of them, 20% adnexal involvement, 28% anterior segment involvement, 33% posterior segment involvement, 11% neuro-ophthalmic abnormality, 4% orbital involvement were present. 76% patients belonged to WHO clinical stage 2 and 3. 51% had CD4+ T cell counts <200 cells/µl.Conclusions: Posterior segment followed by anterior segment are the most commonly encountered ocular manifestations of HIV infection. Low CD4 count is good predictor for ocular manifestations in HIV positive patients. Higher WHO stage is also directly related with the severity of the ocular symptoms. Routine baseline ophthalmic screening to all HIV positive patients are necessary to prevent ocular morbidity.

Ocular manifestations in tuberculosis cases with HIV in Nepal

2019 ◽  
Vol 11 (2) ◽  
pp. 130-137
Author(s):  
Subash Bhatta ◽  
D. N. Shah ◽  
Meenu Choudhary ◽  
Ajit Thakur ◽  
Nayana Pant
Keyword(s):  
Pulmonary Tuberculosis ◽  
Opportunistic Infections ◽  
Retinal Vasculitis ◽  
University Teaching ◽  
Ocular Tissue ◽  
Ocular Involvement ◽  
Extra Pulmonary Tuberculosis ◽  
Cd4 Counts ◽  
Ocular Manifestations ◽  
Extra Pulmonary

Introduction: TB has seen resurgence associated with HIV. Tuberculosis can affect any ocular tissue. The association of HIV with TB is supposed to increase the incidence and plethora of ocular manifestations in tuberculosis. Objectives: To study the various ocular manifestations seen in tuberculosis patients with associated HIV infection. Material and Methods: This hospital based, cross sectional descriptive study was conducted in Tribhuvan University, Teaching Hospital, Maharajgunj, Nepal and Geta Eye Hospital, Kailali from 2010 to 2015. Diagnosed cases of pulmonary and extra pulmonary tuberculosis with HIV co infection were evaluated for ocular manifestations after excluding other opportunistic infections. Results: Of 70 cases eligible for the study, extra pulmonary tuberculosis was seen in60% of the cases. 5 patients (7.1 %) had ocular manifestations. CD4 counts were <50/mm3 in 3 cases. Ocular involvement was seen in the form of choroidal granulomas, papillitis, cranial nerve palsy, retinal vasculitis and central serous chorioretinopathy. Conclusion: This study demonstrated that ocular involvement is a frequent finding in cases with tuberculosis and HIV. Ocular findings are more common in cases with lesser CD4 counts. As ocular tuberculosis can be visually devastating, we recommend regular ocular evaluation of all patients with HIV and systemic tuberculosis.

Ocular Manifestations in Rheumatoid Arthritis, Connective Tissue Disease, and Vasculitis: A Systematic Review and Metaanalysis

2020 ◽  
Vol 48 (1) ◽  
pp. 25-34
Author(s):  
Matthew A. Turk ◽  
Jacqueline L. Hayworth ◽  
Tatiana Nevskaya ◽  
Janet E. Pope
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Connective Tissue ◽  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Dry Eye ◽  
Keratoconjunctivitis Sicca ◽  
Connective Tissue Diseases ◽  
Ocular Manifestations ◽  
Eye Involvement

Objective.Rheumatoid arthritis (RA) and other rheumatic diseases may present with ocular manifestations.The purpose of our work was to determine the prevalence and type of eye involvement in RA and other connective tissue diseases through a metaanalysis and literature review.Methods.A systematic review of the literature was performed using Medline, Web of Science, and the Cochrane Library from their inceptions until January 7, 2019. Conjunctivitis, keratoconjunctivitis sicca, xeropthalmia, uveitis, eye hemorrhage, optic neuritis, papilledema, orbital disease, retinal artery/vein occlusion, macular edema, retinitis, chorioretinitis, scleritis, iridocyclitits, choroid hemorrhage, blindness, and amaurosis fugax were searched for prevalence in patients with RA, systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), dermatomyositis, polymyositis, systemic sclerosis, Sjögren syndrome (SS), undifferentiated connective tissue disease, giant cell arteritis, granulomatosis polyangiitis (GPA; formerly Wegener granulomatosis), systemic vasculitis, and sarcoidosis.Results.There were 3394 studies identified and 65 included. The prevalence of eye involvement was 18% in RA, 26% in GPA, 27% in giant cell arteritis, 27% in sarcoidosis, 31% in SLE, and 35% in APS. The most common manifestation was dry eye syndrome (“dry eye”; keratoconjunctivitis sicca) in most diseases analyzed, with an especially high frequency of 89% in SS. Anterior and posterior uveitis were the most common ocular complications in sarcoidosis, occurring in 16% (95% CI 3–28) and 6% (95% CI 3–9) of patients, respectively.Conclusion.Eye involvement is present in approximately one-fifth of patients with RA, and a one-quarter to one-third of patients with connective tissue diseases (other than SS at 89%) and vasculitis.

scholarly journals Ocular Manifestations of West Nile Virus

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 641
Author(s):  
Antoine Rousseau ◽  
Oscar Haigh ◽  
Imen Ksiaa ◽  
Moncef Khairallah ◽  
Marc Labetoulle
Keyword(s):  
West Nile Virus ◽  
Virus Infection ◽  
Retinal Vasculitis ◽  
Specific Treatment ◽  
West Nile Virus Infection ◽  
Ocular Involvement ◽  
West Nile ◽  
Ocular Manifestations ◽  
Neuroinvasive Disease ◽  
Permanent Loss

Ocular manifestations are a feature of West Nile virus infection. They mostly occur in association with severe neuroinvasive disease. Linear chorioretinitis is suggestive of the diagnosis and may raise diagnostic suspicion when associated with evocative systemic signs, and in an epidemic context. Various other less specific inflammatory ocular manifestations have been reported, including anterior uveitis, occlusive retinal vasculitis, optic neuritis, and diplopia. The pathophysiology of ocular disease remains unclear, but it reflects the neuroinvasiveness of the disease. Although ocular involvement most often resolves without visual sequelae, some patients may have permanent loss of vision, adding to the need for the development of a specific treatment and/or vaccines.

Unilateral hypopyon associated acute syphilitic posterior placoid chorioretinitis: Unusual presentation leading to HIV diagnosis

2021 ◽  
pp. 004947552199817
Author(s):  
Ashok Kumar ◽  
Poninder Kumar ◽  
Sanjay Kumar Mishra ◽  
Sumit Goyal
Keyword(s):  
Optic Nerve ◽  
Optic Atrophy ◽  
Retinal Vasculitis ◽  
Posterior Uveitis ◽  
Hiv Disease ◽  
Ocular Manifestation ◽  
Outer Retina ◽  
Hiv Diagnosis ◽  
Retrobulbar Neuritis ◽  
Ocular Manifestations

Syphilis has a wide variety of ocular presentations such as anterior or posterior uveitis, chorioretinitis, retinal vasculitis, retinitis, perineuritis, papillitis, retrobulbar neuritis, optic atrophy and optic nerve gumma. Therefore, it is recommended to test every patient with ocular inflammation for syphilis. It is, however, a relatively rare cause of uveitis in HIV disease. A few studies suggested that HIV contributes to the ocular manifestations of syphilis and HIV co-infection in approximately 30%. Acute syphilitic posterior placoid chorioretinopathy is a rare ocular manifestation in immune-competent patients characterised by the development of a deposit in the outer retina. We describe an unusual such presentation with hypopyon.

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