scholarly journals Effect of Biphasic Insulin Aspart 30 Combined with Metformin on Glycaemic Control in Obese People with Type 2 Diabetes

2007 ◽  
Vol 7 (4) ◽  
pp. 335-338 ◽  
Author(s):  
Belma Aščić - Buturović
Keyword(s):  
Blood Glucose ◽  
Glycaemic Control ◽  
Insulin Aspart ◽  
Postprandial Blood Glucose ◽  
Obese People ◽  
Metformin Therapy ◽  
Biphasic Insulin Aspart ◽  
Biphasic Insulin ◽  
Biphasic Insulin Aspart 30

Combination therapy consisting of biphasic insulin aspart 30 bid with metformin provide better glycaemic control in obese patients with diabetes mellitus type 2. In our study, patients who were treated with 2550 mg of metformin, administered in three daily doses had poor glycaemic control. Three months after switching from metformin therapy to treatment with biphasic insulin aspart 30 + metformin twice a day, glycaemic control improved with significant reduction in hemoglobin HbA1c, fasting blood glucose and postprandial blood glucose levels.Biphasic insulin aspart 30 in combination with metformin administered twice a day may be recommended as a starting insulin treatment in obese diabetic persons whose glycaemic control remained poor while on oral metformin therapy alone.

Biphasic Insulin Aspart 30 in Insulin Initiation

2010 ◽  
Vol 7 (2) ◽  
pp. 121
Author(s):  
Wenying Yang ◽  
Keyword(s):  
Blood Glucose ◽  
Glycaemic Control ◽  
Insulin Aspart ◽  
Fasting Blood Glucose ◽  
Postprandial Glucose ◽  
Insulin Initiation ◽  
Biphasic Insulin Aspart ◽  
Biphasic Insulin ◽  
Biphasic Insulin Aspart 30 ◽  
Clinical Literature

This case report concerns a patient with poor glycaemic control on oral antidiabetic drugs who initiated biphasic insulin aspart 30 (BIAsp 30), and reviews supporting clinical literature, alternative treatment choices and the options for intensification. During the six-month follow-up after initiation of BIAsp 30, glycosylated haemoglobin (HbA1c) was reduced from 10.2 % to 6.4 %, mean fasting blood glucose (FBG) was reduced from 9.0 mmol/l to 6.8 mmol/l and mean postprandial glucose (PPG) was reduced from 15.3 mmol/l to 8.8 mmol/l. Body weight increased by 4 kg. The patient experienced eight episodes of hypoglycaemia over the six-month period (four pre-lunch, one at bedtime and three nocturnal). The patient had six episodes with blood glucose (BG) <4.0 mmol/l but no episodes with BG <2.8 mmol/l. Insulin initiation with a premix insulin analogue offers a simple and convenient regimen of once- or twice-daily dosing and provides effective glycaemic control by providing coverage of both FBG and PPG.

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