scholarly journals Associations between gene polymorphisms, breeding values, and glucose tolerance test parameters in German Holstein sires

2018 ◽  
Vol 63 (No. 5) ◽  
pp. 167-173
Author(s):  
J. Čítek ◽  
L. Hanusová ◽  
M. Brzáková ◽  
L. Večerek ◽  
L. Panicke ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Gene Polymorphisms ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Protein Yield ◽  
Breeding Value ◽  
Breeding Values ◽  
Test Parameters ◽  
Milk Performance ◽  
Estimated Breeding Values

The association between several gene polymorphisms, the estimated breeding values for milk performance traits, and glucose metabolism measured by the glucose tolerance test (GTT) in German Holstein sires were evaluated. Polymorphisms in DGAT1, GH1, GHR, FASN, and OLR1 genes were not associated with the GTT. A significant relationship was obtained for the DGAT1 AA/GC polymorphism and estimated breeding values for milk performance (milk yield, fat and protein yield, fat and protein percentage). The polymorphism in GHR was significantly associated with estimated breeding values for fat yield, and the polymorphism in OLR1 with estimated breeding value for protein yield. It shows the importance of the polymorphisms and makes their use in the breeding possible. GTT may be helpful in metabolic analyses, but the gene polymorphisms assessed in our study were not associated with GTT traits and further studies should examine other gene polymorphisms to support the role of GTT for potential breeding purposes.

scholarly journals Zusammenhang zwischen Parametern des Glukosetoleranztestes bei Jungbullen und deren Nachkommenzuchtwert

2000 ◽  
Vol 43 (3) ◽  
pp. 231-240 ◽  
Author(s):  
L. Panicke ◽  
R. Staufenbiel ◽  
O. Burkert ◽  
E. Fischer ◽  
F. Reinhardt
Keyword(s):  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Correlation Coefficients ◽  
Tolerance Test ◽  
Intravenous Glucose Tolerance Test ◽  
Breeding Value ◽  
Central Position ◽  
Intravenous Glucose ◽  
Genetic Determination ◽  
Breeding Values

Abstract. Title of the paper: Relationships between parameters of the glucose tolerance test by young sires and estimated their breeding values A high milk Performance connected to a sound health regarding metabolism and a sufficient fertility in dairy cows depends on a well balanced distribution of energy in body. The terms "type of tumover" and "type of deposition" embody two extremes of food energy preferably for milk production or for body composition. Insulin plays an outstanding role based on its central position in energetic metabolism. The function of insulin may be recorded by means of the intravenous glucose tolerance test (GTT). The reaction of insulin and glucose was investigated after infusion of 1 g Glucose/kg075 because of the probable genetic determination of the reactive ability. The coefficients of heritability range from h2 = 0.16 + 0.10 to h2 = 0.28 ± 0.16. Investigating 28 sires the correlation coefficients amount to r = 0.5 for parameters of gluccose tolerance test and estimated breeding values which is closer than those between pedigree breeding value and glucose tolerance test.This is expecting additional Information for young sires before the insert of the test.

scholarly journals Schätzung des Prüfniveaus metabolischer Merkmale beim Glukose-Toleranz-Test (GTT) an Jungbullen

2003 ◽  
Vol 46 (2) ◽  
pp. 167-176 ◽  
Author(s):  
L. Panicke ◽  
E. Fischer ◽  
B. Fischer ◽  
R. Staufenbiel
Keyword(s):  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Post Partum ◽  
Tolerance Test ◽  
The Other ◽  
Metabolic Parameters ◽  
Breeding Value ◽  
One Year ◽  
Pedigree Breeding ◽  
Selection Of

Abstract. Title of the paper: Level estimation of metabolic parameters in the glucose tolerance test (GTT) of young bulls The metabolic parameters of the glucose tolerance test are suitable for an additional recommendation for the valuation of the breeding bulls before the start of the offspring’s test could be given. Very important is the level of glucose half live to the begin of lactation of the cows. The other limit is the hyperglycemias greater than 10 mmol/l (or 180 mg/dl) in the glucose level in the blood. The glucose half live measured nearly 48 minutes is comparable in the 8th week post partum in lactation of cows with the young bulls in the age one year. Their combination with the pedigree breeding value is leading to increase of information, that could be utilised to the selection of improper bulls if the present results were confirmed.

scholarly journals SP649LONGITUDINAL ASSESMENT OF ORAL GLUCOSE TOLERANCE TEST PARAMETERS FOR THE PREDICTION OF PANCREAS TRANSPLANT DYSFUNCTION

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i311-i311 ◽  
Author(s):  
Pascaline Alix ◽  
Fanny Buron ◽  
Maria Brunet ◽  
Olivier Thaunat ◽  
Cécile Chauvet ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Pancreas Transplant ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Test Parameters

scholarly journals Comparison of breeding values among cows with exceptional longevity and their contemporary herdmates in German Holsteins

2016 ◽  
Vol 59 (1) ◽  
pp. 71-77 ◽  
Author(s):  
K. Abfalter ◽  
W. Brade ◽  
O. Distl
Keyword(s):  
Somatic Cell ◽  
Milk Production ◽  
Negative Correlation ◽  
Somatic Cell Count ◽  
Protein Yield ◽  
Breeding Value ◽  
Breeding Values ◽  
Exceptional Longevity ◽  
Positive Weights ◽  
Estimated Breeding Values

Abstract. The present analysis compares the estimated breeding values (EBVs), relative breeding values (RBVs), and daughter yield deviations (YDs) of cows with exceptional longevity with their contemporary herdmates. In addition, the relative breeding values of their sires were compared among these two daughter groups; the RBVs of the sires were also compared with the proportion of their daughters with exceptional longevity. Data included 5037 sires born between 1963 and 1996 with a total of 61 988 daughter; of these sires, 486 had sired daughters that completed more than nine lactations (exceptional cows) and 4957 sires had sired the contemporary herdmates. Exceptional cows had on average significantly lower EBVs for milk yield, fat and protein yield, and significantly lower YDs for milk and protein yield in the first three lactations, significantly lower RBVs for milk production and type but significantly higher RBVs for somatic cell score and functional longevity. The sires of exceptional cows had significantly higher RBVs for somatic cell count (RZS), functional longevity (RZN), and fitness (RZFit) in comparison to the sires of contemporary herdmates. Correlations among the proportion of exceptional cows per sire and RZN, RZS as well as RZFit were positive, whereas milk production (RZM) showed a negative correlation. An increase in the number of cows with exceptional longevity may be possible through a relative total breeding value with high positive weights for RZN, RZS, and RZFit but negative weights for RZM and type (RZE).

scholarly journals Untersuchungen an den Ergebnissen der Zuchtwertschätzung von Holstein Bullen und Kühen in Deutschland

2003 ◽  
Vol 46 (2) ◽  
pp. 113-126 ◽  
Author(s):  
H. H. Swalve ◽  
K. Höver
Keyword(s):  
Milk Fat ◽  
Protein Yield ◽  
Breeding Value ◽  
Breeding Values ◽  
Value Estimation ◽  
Annual Trends ◽  
Estimated Breeding Values ◽  
Using Data ◽  
High Degree ◽  
Genetic Trends

Abstract. Title of the paper: Examinations using the results of breeding value estimation for Holstein sires and cows in Germany Besides for selection purposes, estimated breeding values can be used to analyze genetic trends and structures in populations. Using data of 2,440,261 cows from four regions in Germany, genetic trends for all cows under test (registered and grade) were calculated for the period of birth years 1992 to 1999. For milk, fat, and protein yield annual trends on average were 111 kg, 3.2 kg, and 3.3 kg, respectively. An analysis of the use of proven sires revealed that a relatively large proportion of bulls get second crop daughters. Most of them, however, are used in a very limited way. The differential use of sires by breeders besides production is highly influenced by type proofs although in this respect clear differences exist between regions. An analysis comparing first proofs of young bulls with their later proofs based on additional second crop daughters for all German Holstein breeding organisations showed a high degree of agreement between the two proofs. However, this analysis was based on only 127 sires that were used more widely (plus > 500 second crop daughters).

scholarly journals Implementation of an Economic Lifetime Net Merit for the Dual-Purpose German Black Pied Cattle Breed

Agriculture ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 41
Author(s):  
Saskia Meier ◽  
Danny Arends ◽  
Paula Korkuć ◽  
Sandra Kipp ◽  
Dierck Segelke ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Dairy Cattle ◽  
Milk Yield ◽  
Cattle Breed ◽  
Breeding Value ◽  
Dual Purpose ◽  
Breeding Values ◽  
Fitness Traits ◽  
Milk Performance ◽  
Estimated Breeding Values

Recently, a Total Merit Index (RZ€) has been developed for German Holstein dairy cattle on the basis of margin in Euro. Our aim was to adjust this lifetime net merit for the dual-purpose German Black Pied cattle breed (DSN) accounting for beef production in addition to milk performance and fitness traits. We used the estimated breeding values of DSN sires and developed a breeding value for carcass weight and quality. Furthermore, we adjusted the German Holstein marginal profits per standard deviation, which are used to calculate the estimated breeding values, to DSN-specific values. The DSN Net Merit is the sum of the three sub-indices DSN Net Milk, DSN Net Fitness, and DSN Net Beef, which contribute to the DSN Net Merit with 52.84%, 43.43%, and 3.73%, respectively. The DSN Net Merit that was calculated for 33 DSN sires ranged between EUR −1114 and +709. The DSN Net Merit strongly correlates with the Total Merit Index. The implementation of the DSN Net Merit is useful for selection and mating decisions. Especially, the sub-index DSN Net Beef, which does not correlate with existing breeding values, can be used to maintain the dual-purpose character of DSN while modestly improving milk yield. The approach can be easily adapted to other dual-purpose breeds.

scholarly journals Variation und Eignung von physiologischen Merkmalen des Glukosetoleranztestes für die indirekte Eigenleistungsprüfung von Jungbullen

2001 ◽  
Vol 44 (4) ◽  
pp. 381-394
Author(s):  
L. Panicke ◽  
E. Fischer ◽  
R. Staufenbiel
Keyword(s):  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Nutritional State ◽  
Breeding Value ◽  
Experimental Conditions ◽  
Genetic Determination ◽  
Physiological Indicators ◽  
The Mean ◽  
Physiological Indicator

Abstract. Title of the paper: Variation and suitability of physiological indicators of the glucose tolerance test for the indirectly evaluation of young bulls The parameters of glucose tolerance test are suitable for an additional recommendation for the valuation of the breeding bulls before the start of test could be given. This show the Variation, the genetic determination and the mean correlations between physiological indicator and estimated breeding value by 0.40 to 0.50. The offspring's breeding value is suitable equivalent examined physiological indicators. These relationships are affected by factors such as experimental conditions, age and nutritional State of animals.

scholarly journals The Breeding Values of German Holstein Sires and the <i>DGAT1</i> Polymorphism

2007 ◽  
Vol 50 (2) ◽  
pp. 136-146
Author(s):  
J. Citek ◽  
V. Rehout ◽  
E. Hradecka ◽  
L. Vecerek ◽  
L. Panicke
Keyword(s):  
Milk Yield ◽  
Genetic Background ◽  
Protein Yield ◽  
Breeding Value ◽  
Fat Percentage ◽  
Female Population ◽  
Breeding Values ◽  
Dgat1 Gene ◽  
Milk Performance ◽  
Fat Yield

Abstract. The effect of the genotypes and alleles at nucleotide positions 10433 and 10434 of the DGAT1 gene on the breeding values for milk performance of German Holstein sires born in 1993 (n=66), and in 1998-2001 (n=200) was analyzed. The differences in breeding values had in both years the same trend. In the younger sires, the breeding value for fat percentage was higher by 0.42 % in the Lysine homozygotes compared to the Alanine homozygotes (P<0.001). A higher milk breeding value in the Alanine homozygotes (811 kg) was found compared to the Lysine homozygotes (256 kg) (P<0.001), and the fat yield breeding value was higher in the Lysine sires (DGAT1K/DGAT1K 29.6, DGAT1A/DGAT1A 15.9). The breeding value for the protein percentage was higher in the sires carrying the Lysine variant (0.02) than in the Alanine homozygotes (- 0.03, P<0.05), and the protein yield was higher in the Alanine homozygotes (DGAT1K/DGAT1K 10.9, DGAT1A/DGAT1A 25.0, P<0.001). Because of the high emphasis of the index on the protein yield, the relative breeding value for milk was 110 among Alanine homozygotes, and 104 among Lysine. Comparing old and young sires, the genetic background against which the effect of DGAT1 is evaluated has changed. The selection on breeding value for protein yield increased the prevalence of DGAT1A/DGAT1A genotypes in protein and milk yield, and in relative breeding value for milk. In the old group, there was the highest protein yield in the heterozygous sires DGAT1KA, it could be explained by another genetic background of the tested female population. Because the breeding value for fat percentage of heterozygous sires has lain within the values of homozygotes in both old and young sires, we assume the intermediary heredity on the locus. The differences of genotypic and allelic frequencies among old and young sires were not significant, however, there was certain tendency of increase of allele A (0.60 old sires, 0.64 young). On the results of this paper, the locus of DGAT1 offers information for evaluation of breed animals.

scholarly journals Parameters of glucose tolerance test traits in dairy cattle

2006 ◽  
Vol 49 (2) ◽  
pp. 120-132
Author(s):  
G. Freyer ◽  
R. Staufenbiel ◽  
E. Fischer ◽  
L. Panicke
Keyword(s):  
Glucose Tolerance ◽  
Dairy Cattle ◽  
Fixed Effects ◽  
Glucose Tolerance Test ◽  
Original Data ◽  
Tolerance Test ◽  
Logarithmic Transformation ◽  
Breeding Values ◽  
Glucose Challenge ◽  
Dairy Bulls

Abstract. Numerous studies in dairy cattle focused on measuring the content of hormones, metabolites and enzyme activities in blood. Response on glucose challenge in 620 dairy bulls within a defined period of 340 … 450 days of age is targeted on within this paper. The time response course after glucose challenge was the basis for selecting corresponding response traits. Deviation from normal distribution was taken into account by means of comparing parameters of original data, after logarithmic transformation and breeding values obtained from both. The residual plots did not confirm the necessity of logarithmic transformation. After evaluating fixed effects trait-specifically, individual breeding values for glucose tolerance test traits were estimated. Heritability coefficients were promising for using these traits in cattle breeding. Trait specific heritability coefficients for G0 was 0.22 and 0.26, for Ga 0.23 and 0.18, for GHL 0.31 and 0.39 from logarithmic and original trait observations, respectively.

scholarly journals Effect of DGAT1 polymorphisms on the estimated breeding values of Czech Simmental sires

2014 ◽  
Vol 59 (No. 8) ◽  
pp. 365-373 ◽  
Author(s):  
L. Hanusová ◽  
A. Míková ◽  
L. Večerek ◽  
D. Schroeffelová ◽  
V. Řehout ◽  
...  
Keyword(s):  
Milk Yield ◽  
Positive Association ◽  
Protein Yield ◽  
Coding Region ◽  
Fat Percentage ◽  
Breeding Values ◽  
Homozygous Genotype ◽  
Dgat1 Gene ◽  
Milk Performance ◽  
Estimated Breeding Values

The aim was to evaluate the effect of polymorphisms in the promoter and in the coding region of the DGAT1 gene on the estimated breeding values (EBV) of Czech Simmental sires. The K232A polymorphism (n = 191) in the coding region was genotyped by PCR/RFLP, and the KU and SA polymorphisms in the promoter (n = 203) were identified in an automatic sequencer. In the K232A polymorphism, the frequency of the genotype AA (Alanine) was greater than that of the genotype KA, the homozygous genotype KK (Lysine) was not found. Similarly, the allele A predominated over the K allele (0.945 and 0.055). The EBV for milk performance have been assigned to the genotypes, and the associations quantified. For the AA genotype and A allele, positive association with EBV of milk yield and protein yield was found, and negative association with the breeding values of fat percentage and yield, and protein percentage, but only the value of fat content was found to be significant. The positive non-significant association of the A variant with the protein yield was caused by the high milk yield. In the KU polymorphism, the CC genotype was associated significantly with lower EBV for the fat percentage, both the C allele and the CC genotype were associated with higher EBV for milk yield, so both the fat and the protein yield were non-significantly increased. For the diplotypes K232A/KU, there was a significant association with the fat percentage. The AACC combination seemed to have some breeding potential. The K232A polymorphism explained maximum of 6.2% of EBV variability, the KU polymorphism of 4.4%, and the SA polymorphism of 4.2%. The diplotypes K232A/KU explained maximum of 7.4% of variability. The highest proportion of variability was explained for fat percentage. The results confirmed the important role of the BTA14 region in controlling milk performance. &nbsp;

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