scholarly journals Mitochondrial D-loop sequence variation among Hucul horse

2013 ◽  
Vol 58 (No. 10) ◽  
pp. 437-442 ◽  
Author(s):  
V. Czerneková ◽  
T. Kott ◽  
I. Majzlík
Keyword(s):  
Mitochondrial Dna ◽  
Genetic Information ◽  
Sequence Variation ◽  
Dna Typing ◽  
Conservation Strategies ◽  
Base Pairs ◽  
Horse Population ◽  
Loop Region ◽  
Loop Sequence ◽  
D Loop

Genetic variation in the Czech Hucul horse population was analyzed using a sequence analysis of the D-loop region of mitochondrial DNA. One hundred and sixty-five Hucul horses were tested. Sequencing of the 700-base pairs fragment of the mitochondrial DNA D-loop region revealed 38 mutation sites representing 14 haplotypes, which were clustered into six haplogroups. The genetic information obtained from the mitochondrial DNA typing is of utmost importance for the future breed-conservation strategies.  

scholarly journals Sequence variation and structural conservation in the D-loop region and flanking genes of mitochondrial DNA from Japanese pond frogs.

2000 ◽  
Vol 75 (2) ◽  
pp. 79-92 ◽  
Author(s):  
Masayuki Sumida ◽  
Hideki Kaneda ◽  
Yoji Kato ◽  
Yasushi Kanamori ◽  
Hiromichi Yonekawa ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Sequence Variation ◽  
Loop Region ◽  
D Loop ◽  
Structural Conservation

scholarly journals Sequence variation data of the mitochondrial DNA D-loop region of the captive Malayan Gaur (Bos gaurus hubbacki)

Data in Brief ◽  
2019 ◽  
Vol 24 ◽  
pp. 103532 ◽  
Author(s):  
Badrul Munir Md-Zain ◽  
Aqilah Abdul-Aziz ◽  
Nor Rahman Aifat ◽  
Nur Syafika Mohd-Yusof ◽  
Nadiatur Akmar Zulkifli ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Sequence Variation ◽  
Loop Region ◽  
Variation Data ◽  
D Loop ◽  
Bos Gaurus

scholarly journals Mitochondrial D-loop sequence variation among autochthonous horse breeds in Croatia

2009 ◽  
Vol 54 (No. 3) ◽  
pp. 101-111 ◽  
Author(s):  
A. Ivanković ◽  
J. Ramljak ◽  
M. Konjačić ◽  
N. Kelava ◽  
P. Dovč ◽  
...  
Keyword(s):  
Proximal Part ◽  
Conservation Strategy ◽  
Selection Strategy ◽  
Horse Population ◽  
Mitochondrial Haplotypes ◽  
Loop Region ◽  
Loop Sequence ◽  
D Loop ◽  
Endangered Breed ◽  
Two Populations

Genetic variation in three Croatian coldblood horse populations was analysed using a sequence analysis of the proximal part (nt 15 498–15 821) of the D-loop region of mtDNA. Twenty unrelated horses were chosen from the Posavina horse and the Croatian Coldblood breeds and fifteen horses from the Murinsulaner horse population. Sequencing of the proximal part of the mtDNA D-loop region revealed 26 polymorphic sites representing thirty haplotypes which were clustered into eight haplogroups. A wide variety of mitochondrial haplotypes of the analysed horse breeds were clustered into eight different haplogroups. Two haplogroups (D and F) were specific to Posavina horse, five haplogroups were shared among the Croatian Coldblood and Murinsulaner horse, the fact that can be explained by selection strategy at the beginning of the 20<sup>th</sup> century and possible gene flow between the two populations. These results indicate the presence of many ancient maternal lineages with high diversity in mtDNA. The genetic information based on mtDNA typing has a great importance for the future breed conservation strategy, especially for the critically endangered breed such as Murinsulaner horse.

Mitochondrial DNA D-loop sequence variation in maternal lineages of Iranian native horses

2012 ◽  
Vol 44 (2) ◽  
pp. 209-213 ◽  
Author(s):  
M. Moridi ◽  
A. A. Masoudi ◽  
R. Vaez Torshizi ◽  
E. W. Hill
Keyword(s):  
Mitochondrial Dna ◽  
Sequence Variation ◽  
Loop Sequence ◽  
D Loop

scholarly journals Mitochondrial DNA Methylation and Human Diseases

2021 ◽  
Vol 22 (9) ◽  
pp. 4594
Author(s):  
Andrea Stoccoro ◽  
Fabio Coppedè
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Mitochondrial Genome ◽  
Nuclear Dna ◽  
Epigenetic Modification ◽  
Nuclear Genome ◽  
Epigenetic Modifications ◽  
Human Diseases ◽  
Loop Region ◽  
D Loop

Epigenetic modifications of the nuclear genome, including DNA methylation, histone modifications and non-coding RNA post-transcriptional regulation, are increasingly being involved in the pathogenesis of several human diseases. Recent evidence suggests that also epigenetic modifications of the mitochondrial genome could contribute to the etiology of human diseases. In particular, altered methylation and hydroxymethylation levels of mitochondrial DNA (mtDNA) have been found in animal models and in human tissues from patients affected by cancer, obesity, diabetes and cardiovascular and neurodegenerative diseases. Moreover, environmental factors, as well as nuclear DNA genetic variants, have been found to impair mtDNA methylation patterns. Some authors failed to find DNA methylation marks in the mitochondrial genome, suggesting that it is unlikely that this epigenetic modification plays any role in the control of the mitochondrial function. On the other hand, several other studies successfully identified the presence of mtDNA methylation, particularly in the mitochondrial displacement loop (D-loop) region, relating it to changes in both mtDNA gene transcription and mitochondrial replication. Overall, investigations performed until now suggest that methylation and hydroxymethylation marks are present in the mtDNA genome, albeit at lower levels compared to those detectable in nuclear DNA, potentially contributing to the mitochondria impairment underlying several human diseases.

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