scholarly journals Naturally occurring recombinant isolate of Pea seed-borne mosaic virus – Short Communication

2019 ◽  
Vol 55 (No. 3) ◽  
pp. 167-171
Author(s):  
Milan Navrátil ◽  
Dana Šafářová

Whole genome sequences of three Czech Pea seed-borne mosaic virus isolates belonging to P1 pathotype and causing different symptom intensity were obtained. Using RDP4 analysis the natural recombinant isolate PSB204CZ bearing two breakpoints in nucleotide positions 4053 and 6080 was identified. The isolate was composed of fragment 2028 nt in length partially covering CI and 6K2 regions of the minor parent (PSB262CZ) incorporated into the major parent (PSB194CZ). The results suggest that the observed recombination in CI-6K2 region is responsible for severity of developed symptoms. This observation detected for the first time natural recombination within PSbMV isolates of an important pathogen of leguminous plants.

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2798
Author(s):  
Serena Fiorito ◽  
Francesco Epifano ◽  
Lorenzo Marchetti ◽  
Salvatore Genovese

Selenium-containing compounds are gaining more and more interest due to their valuable and promising pharmacological properties, mainly as anticancer and antioxidant agents. Ebselen, the up to now only approved drugs, is well known to possess very good glutathione peroxidase mimicking effects. To date, the most of efforts have been directed to build pure synthetic Se containing molecules, while less attention have been devoted to Se-based semisynthetic products resembling natural compounds like terpenes, polyphenols, and alkaloids. The aim of this short communication is to report the synthesis of the first example of a Se-phenylpropanoids, namely selenoauraptene, containing a selenogeranyl side chain in position 7 of the umbelliferone core. The key step was the Newman-Kwart rearrangement to obtain a selenocarbamate in which the Se atom was directly attached to umbelliferone (replacing its 7-OH function) followed by hydrolysis to get diumbelliferyl diselenide, which was finally easily converted to the desired Se-geranyl derivative in quite a good overall yield (28.5%). The synthesized adduct displayed a greater antioxidant and a radical scavenger in vitro activity than parent auraptene. The procedure we describe herein, to the best of our knowledge for the first time in the literature, represents an easy-to-handle method for the synthesis of a wide array of seleno analogues of naturally occurring biologically active oxyprenylated secondary metabolites.


1981 ◽  
Vol 87 (1) ◽  
pp. 1-10 ◽  
Author(s):  
R. Hampton ◽  
G. Mink ◽  
L. Bos ◽  
T. Inouye ◽  
M. Musil ◽  
...  
Keyword(s):  

2017 ◽  
Vol 162 (5) ◽  
pp. 1335-1339 ◽  
Author(s):  
Wenwu Lin ◽  
Lu Wang ◽  
Wenkai Yan ◽  
Lingli Chen ◽  
Huihuang Chen ◽  
...  

2007 ◽  
Vol 152 (11) ◽  
pp. 2073-2078 ◽  
Author(s):  
M. A. Achon ◽  
L. Serrano ◽  
N. Alonso-Dueñas ◽  
C. Porta

2015 ◽  
Vol 10 (11) ◽  
pp. 1934578X1501001
Author(s):  
Salvatore Genovese ◽  
Vito Alessandro Taddeo ◽  
Francesco Epifano ◽  
Serena Fiorito

Naturally occurring 2-hydroxy-1,4-naphthoquinones are well known to form readily stable complexes with transition metals. In this short communication we describe for the first time the synthesis and preliminary data about structural characterization of complexes between two naturally widespread 2-hydroxy-1,4-naphthoquinones, namely lapachol (1) and lawsone (2), with selected lanthanides like lanthanum, gadolinium, and ytterbium. When tested as cytotoxic compounds, such complexes exhibited an activity that was either higher or equal to that of the parent naphthoquinone.


2020 ◽  
Vol 9 (2) ◽  
Author(s):  
H. Tall ◽  
J. Aribi ◽  
S. Camara ◽  
A. Pinel-Galzi ◽  
N. Poulicard ◽  
...  

Rice yellow mottle virus in Senegal is reported here for the first time. The near-complete genomic sequences of two isolates (Se1 and Se5) were obtained. A comparison with 18 sequences from West Africa revealed a new cluster with an isolate from Gambia, located at a basal position in the phylogenetic tree.


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