scholarly journals Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity

2018 ◽  
Vol 27 (6) ◽  
pp. 715-720 ◽  
Author(s):  
Tolga Mercantepe ◽  
Yıldıray Kalkan ◽  
Levent Tumkaya ◽  
İbrahim Sehitoglu ◽  
Filiz Mercantepe ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Protective Effects ◽  
Necrosis Factor Alpha ◽  
Pancreatic Toxicity ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Infliximab alleviates the mortality, mesenteric hypoperfusion, aortic dysfunction, and multiple organ damage in septic rats

2017 ◽  
Vol 95 (7) ◽  
pp. 866-872 ◽  
Author(s):  
Erdem Kamil Ozer ◽  
Mustafa Tugrul Goktas ◽  
Ibrahim Kilinc ◽  
Aysun Toker ◽  
Hulagu Bariskaner ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Organ Damage ◽  
Multiple Organ ◽  
Protective Effects ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Mesenteric Perfusion ◽  
Necrosis Factor

Tumor necrosis factor-alpha (TNF-α) is a pivotal mediator that triggers inflammatory process, oxidative stress, and multiple organ injury in sepsis. We investigated the effects of infliximab on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in cecal ligation and puncture (CLP)-induced sepsis. Wistar rats were divided into Sham, CLP, Sham+infliximab, and CLP+infliximab subgroups. Twenty-four hours before the operations, rats were injected intraperitoneally with infliximab (7 mg/kg) or vehicle (saline; 1 mL/kg). Twenty hours after the operations, MBF and phenylephrine responses of isolated aortic rings were measured. Tissue damages were examined biochemically and histopathologically. Furthermore, survival rates were monitored throughout 96 h. Infliximab improved survival, mesenteric perfusion, and aortic function after CLP. Increases of serum AST, ALT, LDH, BUN, Cr, and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6) induced by CLP were blocked by infliximab. Infliximab prevented malondialdehyde elevations in septic liver, lung, spleen, and kidney tissues, as well as glutathione reductions in septic liver, spleen, and kidney tissues. Protective effects of infliximab on multiple organ damage were also observed histopathologically. Infliximab showed protective effects in sepsis due to its improvement effects on mesenteric perfusion, aortic function, and its anti-inflammatory and antioxidative effects.

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