scholarly journals The protective effect of Gingko biloba in a rat model of ovarian ischemia/reperfusion injury: Improvement in histological and biochemical parameters

2018 ◽  
Vol 27 (5) ◽  
pp. 591-597 ◽  
Author(s):  
Nuri Yildirim ◽  
Deniz Simsek ◽  
Semir Kose ◽  
Alkim Gulsah Sahingoz Yildirim ◽  
Cagri Guven ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Biochemical Parameters ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Gingko Biloba

scholarly journals The long-term protective effect of tadalafil on spermatogenesis following testicular ischemia-reperfusion injury in a rat model

2020 ◽  
Author(s):  
Bomi Kim ◽  
EunHye Lee ◽  
BoHyun Yoon ◽  
So Young Chun ◽  
Jae-Wook Chung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Testicular Torsion ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Group A ◽  
Testicular Ischemia

Abstract Background Testicular torsion is a urological emergency in which misdiagnosis and inappropriate treatment can lead to testicular atrophy and male infertility owing to ischemia-reperfusion injury (IRI). Although experimental studies of testicular torsion have been preceded, promising therapeutic agents based on the long-term effect for spermatogenesis have not been identified in testicular ischemia reperfusion injury (IRI) animal model. Tadalafil, one of the phosphodiesterase-5 inhibitors commonly used in the treatment of erectile dysfunction, has recently reported a protective effect against IRI in several organs. In this study, we evaluated the long-term protective effect of tadalafil for spermatogenesis in a rat testicular IRI model. Methods Forty-eight adolescent Sprague–Dawley rats were divided into 6 groups (A-F). Sham operation was performed in group A. Group B received surgical 720-degree torsion of the left testis without any medication. Groups C, D, E, and F were operated surgical torsion with tadalafil at varying doses (0.3 mg/kg, 1.0 mg/kg) and durations (single or daily administration for 4 weeks). Detorsion was performed after 3 hour of torsion in all rats except the sham group. Four weeks after operation, both testes were evaluated of spermatogenesis using Johnsen scoring. To evaluate the protective effect of tadalafil against oxidative stress by IRI, malondialdehyde (MDA) and superoxide dismutase (SOD) level were analyzed via ELISA in both testes 4 hour after detorsion in the same experiments as in group A, B, and C. Results For the evaluation of spermatogenesis according to doses, the groups with high-dose tadalafil showed a higher Johnsen scores than low-dose counterparts. The groups with daily administration for 4weeks were observed a higher Johnsen scores than those given a single administration. Furthermore, molecular markers (MDA and SOD) related with oxidative stress and histopathologic findings showed remarkable improvement after tadalafil administration. Conclusion Tadalafil alleviated long-term deterioration of spermatogenesis and oxidative stress by restoring antioxidant status after testicular IRI rat model. Furthermore, it demonstrated a protective effect against testicular IRI in a time- and dose-dependent manner.

Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury

2008 ◽  
Vol 27 (1) ◽  
pp. 117-122 ◽  
Author(s):  
Murat Bozlu ◽  
Deniz Acar ◽  
Selahittin Cayan ◽  
Savas Aktas ◽  
Ahmet Tunckiran
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Testicular Ischemia

scholarly journals Protective effect of erdosteine on erythrocyte deformabilityin a rat model of lower limb ischemia/reperfusion injury

2018 ◽  
Vol 48 ◽  
pp. 187-190 ◽  
Author(s):  
Abdullah ÖZER ◽  
Hüseyin DEMİRTAŞ ◽  
Faruk Metin ÇOMU ◽  
Dilek ERER ◽  
Yiğit KILIÇ ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Lower Limb ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Lower Limb Ischemia

scholarly journals Protective Effect of Ethanol Extract of Celery (Apium graveolens L) on Kidney Damage in Ischemia/ Reperfusion Injury Rats Model

Molekul ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 11
Author(s):  
Afifah Afifah ◽  
Khusnul Muflikhah ◽  
Viva Ratih Bening Ati ◽  
Rizki Maulana Tsani ◽  
Dairotul Khasanah ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Ethanol Extract ◽  
Kidney Damage ◽  
Apium Graveolens ◽  
Tubular Injury ◽  
Injury Score

Ischemia/ reperfusion injury (IRI) is marked by the sudden decrease of blood supply to the kidney followed by restoration of blood flow. Ischemic acute kidney injury (AKI) is the leading cause of morbidity and mortality. Therefore, the prevention strategy for decreasing the damage due to IRI is required. Celery (Apium graveolens L) is often consumed as food. Celery has antioxidant and anti-inflammatory effects. This study aimed to investigate the protective effect of the celery on kidney damage in the kidney ischemia/ reperfusion injury rat model.  Twenty-five rats male, 2-3 months old Sprague Dawley were divided into 5 groups: Group 1  was sham operation, group 2 was ischemia/ reperfusion injury (IRI), group 3, 4, 5 were IRI and 250 mg/kgBW, 500 mg/kgBW, 1000 mg/kgBW of ethanol extract of celery respectively for 14 days before and 3 days after operation. Blood serum sample was taken 3 days after the operation for measuring urea, creatinine, superoxide dismuthase (SOD) and nitrite oxide (NO). Hematoxylin-eosin (HE) staining was utilized to examine kidney tubular injury score. Data were analyzed using One-way ANOVA (p<0,05). The ethanol extract of celery at dose 1000 mg/kgBW prevented the increase of urea, creatinine serum, kidney tubular injury score and prevented the decrease of SOD, NO in the kidney ischemia/ reperfusion injury rat model (p<0,05). In conclusion, the ethanol extract of celery has a protective effect on kidney damage in the ischemia/ reperfusion injury rat model.  

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