scholarly journals β2-microglobulin as a marker of systemic lupus erythematosus activity

2018 ◽  
Vol 27 (3) ◽  
pp. 379-382 ◽  
Author(s):  
Iwona Żychowska ◽  
Dorota Suszek ◽  
Magdalena Dryglewska ◽  
Maria Majdan
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Β2 Microglobulin ◽  
Systemic Lupus Erythematosus Activity

The Relationship Between Systemic Lupus Erythematosus Activity and Persistent Positive Antiphospholipid Antibodies

2018 ◽  
Vol 14 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Zhaleh Shariati Sarabi ◽  
Maryam Sahebari ◽  
Ali Etemad Rezaie ◽  
Mohammad Taghi Norouzi ◽  
Kamila Hashemzadeh ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antiphospholipid Antibodies ◽  
Systemic Lupus ◽  
Systemic Lupus Erythematosus Activity ◽  
The Relationship

scholarly journals Evaluation of the serum β2 Microglobulin level in patients with systemic lupus erythematosus and its correlation with disease activity

BioMedicine ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 16 ◽  
Author(s):  
Miramir Aghdashi ◽  
Simak Salami ◽  
Ahmad Nezhadisalami
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Statistical Tests ◽  
Systemic Lupus ◽  
Β2 Microglobulin ◽  
Reactive Protein ◽  
Significant Difference ◽  
Control Study

Background: Designation of disease activity is serious for the management of systemic lupus erythematosus (SLE). Serum level of β2 microglobulin (β2M) may be associated with illness activity in SLE disease. Since the role of β2M for assessing of illness activity in SLE is not completely clear, the current study aimed to discern evaluation of β2M in patients with SLE and its correlation with sickness activity. Materials and Methods: In this case-control study, 50 patients with SLE disease and 25 healthy individuals were selected in Imam Khomeini Hospital in central of Urmia. Blood samples were collected safely from patients, serum was removed, and β2M measured using an ELISA method. The results for other parameters including C reactive protein, C3, C4, anti dsDNA and erythrocyte sedimentation rate were obtained from patients’ medical record. Data analyzed using appropriate statistical tests including Mann-Whitney U test, Independent f-test, Kruskal-Wallis, and Spearman used for analysis of data. Results: In the current study, a significant difference was seen between two groups in terms of β2M (p < 0.001). Remarkable correlation was seen between the level of β2M with disease activity (p < 0.001). Furthermore, there are significant relevancy between the level of β2M with 24-hour urine protein, ESR, disease activity score, and CRP (p < 0.05). Conclusion: The results revealed that serum amount of β2M in SLE patients is higher compared to healthy ones, which is significantly correlated to score of illness activity, CRP, and ESR in patients with SLE disease. Hence β2M might be an excellent serological marker helping the prediction of sickness activity and inflammation in SLE patients.

Anti–α-enolase antibody combined with β2 microglobulin evaluated the incidence of nephritis in systemic lupus erythematosus patients

Lupus ◽  
2019 ◽  
Vol 28 (3) ◽  
pp. 365-370 ◽  
Author(s):  
Y Huang ◽  
L Chen ◽  
K Chen ◽  
F Huang ◽  
Y Feng ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Correlation Analysis ◽  
Lupus Erythematosus ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Healthy Controls ◽  
Systemic Lupus ◽  
Β2 Microglobulin ◽  
Potential Indicator ◽  
Operating Characteristic Curve

Objective Anti–α-enolase antibody (Ab) combined with β2 microglobulin (β2-MG) were investigated to predict the incidence of nephritis in systemic lupus erythematosus (SLE) patients. Methods Levels of serum anti–α-enolase Ab and urinary β2-MG were detected in 115 SLE patients, 29 SLE patients with nephritis and 70 healthy controls by ELISA and immunoturbidimetry, respectively. Furthermore, the correlation between anti–α-enolase Ab combined with β2-MG and the incidence of nephritis in SLE patients was evaluated by correlation analysis. Results The optical density value of serum anti–α-enolase Ab in SLE patients with nephritis (0.84) was greatly increased compared with SLE patients (0.76) or healthy controls (0.54). Moreover, the levels of urinary β2-MG in SLE patients with nephritis (6.75 mg/L) were increased compared with SLE patients (3.45 mg/L) or healthy controls (1.48 mg/L). There was a positive correlation between the level of anti–α-enolase Ab and β2-MG ( r = 0.754). Furthermore, anti–α-enolase Ab combined with β2-MG for evaluating the incidence of nephritis in SLE patients had the best assessment of the effectiveness (area under the receiver operating characteristic curve (AUC): 92.7%) compared with only anti–α-enolase Ab (AUC: 80.9%) or β2-MG (AUC: 84.5%). Conclusion These data suggested that anti–α-enolase Ab may be a potential indicator for the prediction of nephritis in SLE patients.

scholarly journals Urine Chemokines as Biomarkers of Human Systemic Lupus Erythematosus Activity

2004 ◽  
Vol 16 (2) ◽  
pp. 467-473 ◽  
Author(s):  
Brad H. Rovin ◽  
Huijuan Song ◽  
Dan J. Birmingham ◽  
Lee A. Hebert ◽  
Chack Yung Yu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Systemic Lupus Erythematosus Activity

SerumWisteria floribundaagglutinin-positive Mac-2-binding protein can reflect systemic lupus erythematosus activity

Lupus ◽  
2017 ◽  
Vol 27 (5) ◽  
pp. 771-779 ◽  
Author(s):  
S S Ahn ◽  
Y Park ◽  
D D Lee ◽  
A L M Bothwell ◽  
S M Jung ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Binding Protein ◽  
Systemic Lupus ◽  
Systemic Lupus Erythematosus Activity
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