scholarly journals Imatinib in the treatment of chronic myeloid leukemia in children and adolescents is effective and well tolerated: Report of the Polish Pediatric Study Group for the Treatment of Leukemias and Lymphomas

2018 ◽  
Vol 27 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Małgorzata Janeczko ◽  
Maryna Krawczuk-Rybak ◽  
Irena Karpińska-Derda ◽  
Maciej Niedźwiecki ◽  
Katarzyna Musioł ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Children And Adolescents ◽  
Myeloid Leukemia ◽  
Study Group ◽  
Pediatric Study ◽  
Leukemia In Children ◽  
Leukemias And Lymphomas

Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group

2015 ◽  
Vol 63 (3) ◽  
pp. 406-411 ◽  
Author(s):  
Hidemitsu Kurosawa ◽  
Akihiko Tanizawa ◽  
Chikako Tono ◽  
Akihiro Watanabe ◽  
Haruko Shima ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Children And Adolescents ◽  
Myeloid Leukemia ◽  
Study Group ◽  
Pediatric Leukemia ◽  
Lymphoma Study Group

scholarly journals Chronic myeloid leukemia in children and adolescents (A bout 2 cases)

2021 ◽  
Author(s):  
meryeme abddaoui ◽  
ahmed faleh ◽  
imane tlemçani ◽  
sara ben miloud ◽  
moncef amrani hassani
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Tyrosine Kinase ◽  
Children And Adolescents ◽  
Myeloid Leukemia ◽  
Kinase Activity ◽  
Fusion Gene ◽  
Rare Entity ◽  
Tyrosine Kinase Activity ◽  
Leukemia In Children

Pediatric chronic myeloid leukemia is a rare entity (2-5% of childhood leukemias) classified as a myeloproliferative neoplasia characterized by the presence of the BCR-ABL fusion gene, the oncogenic translocation product (9; 22) responsible for the disease through its deregulated tyrosine kinase activity.

Chronic myeloid leukemia in children and adolescents: results of treatment with imatinib mesylate

2012 ◽  
Vol 53 (12) ◽  
pp. 2430-2433 ◽  
Author(s):  
K. C. Lakshmaiah ◽  
Rohan Bhise ◽  
Samit Purohit ◽  
Linu J. Abraham ◽  
D. Lokanatha ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Children And Adolescents ◽  
Imatinib Mesylate ◽  
Myeloid Leukemia ◽  
Results Of Treatment ◽  
Leukemia In Children

scholarly journals How I treat chronic myeloid leukemia in children and adolescents

Blood ◽  
2019 ◽  
Vol 133 (22) ◽  
pp. 2374-2384 ◽  
Author(s):  
Nobuko Hijiya ◽  
Meinolf Suttorp
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Children And Adolescents ◽  
Myeloid Leukemia ◽  
Kinase Inhibitors ◽  
Clinical Investigation ◽  
Limited Experience ◽  
Poor Treatment ◽  
Third Line ◽  
Treatment Free Remission ◽  
Leukemia In Children

AbstractEvidence-based recommendations have been established for treatment of chronic myeloid leukemia (CML) in adults treated with tyrosine kinase inhibitors (TKIs), but the rarity of this leukemia in children and adolescents makes it challenging to develop similar recommendations in pediatrics. In addition to imatinib, which was approved for pediatric CML in 2003, the second-generation TKIs dasatinib and nilotinib were recently approved for use in children, expanding the therapeutic options and pushing allogeneic stem cell transplantation to a third-line treatment of most pediatric cases. Yet, without sufficient data on efficacy and safety specific to pediatric patients, the selection of a TKI continues to rely on clinical experience in adults. Here, we present 4 case scenarios highlighting common yet challenging issues encountered in the treatment of pediatric CML (suboptimal response, poor treatment adherence, growth retardation, and presentation in advanced phases). Limited experience with very young children, the transition of teenagers to adult medicine, and the goal of achieving treatment-free remission for this rare leukemia are additional significant obstacles that require further clinical investigation through international collaboration.

scholarly journals Management of chronic myeloid leukemia in children and adolescents: Recommendations from the Children's Oncology Group CML Working Group

2019 ◽  
Vol 66 (9) ◽  
Author(s):  
Uma Athale ◽  
Nobuko Hijiya ◽  
Briana C. Patterson ◽  
John Bergsagel ◽  
Jeffrey R. Andolina ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Children And Adolescents ◽  
Working Group ◽  
Myeloid Leukemia ◽  
Oncology Group ◽  
Leukemia In Children
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