The Impact of Morin, a Natural Flavonoid, on Cyclophosphamide-Induced Changes in the Oxidative Stress Parameters in Rat Livers

2014 ◽  
Vol 23 (4) ◽  
pp. 505-509 ◽  
Author(s):  
Anna Merwid-Ląd ◽  
Małgorzata Trocha ◽  
Ewa Chlebda-Sieragowska ◽  
Tomasz Sozański ◽  
Marta Szandruk ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Stress Parameters ◽  
Induced Changes ◽  
The Impact ◽  
Rat Livers ◽  
Stress Parameters

The Effect of Borage (Echium amoenum) on the Mouse Heart and Hematology Parameters

2019 ◽  
Vol 19 (2) ◽  
pp. 154-159 ◽  
Author(s):  
Parisa Sadighara ◽  
Atefeh Araghi ◽  
Behrouz Tajdar-oranj ◽  
Leila Peivasteh Roudsari ◽  
Afsaneh Mohajer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Control Group ◽  
Mouse Heart ◽  
Potential Health ◽  
Oxidative Stress Parameters ◽  
Significant Difference ◽  
High Doses ◽  
Hematology Parameters ◽  
The Impact ◽  
Stress Parameters

Background: There has been considerable interest in the potential health benefits of borage. Little information is available regarding the safety of this plant. The purpose of this study was to evaluate the impact of borage on the mouse heart. Methods: Different amounts of borage extract were injected in mice. The mice were randomly divided into 4 groups including group1 (Control group without injection), group2, 3 and 4 that received 12.5 mg/kg, 25 mg/kg and 50 mg/kg respectively for 28 days. Oxidative stress parameters (lipid peroxidation, total glutathione groups assay and cupric assay) and biochemical (Creatine kinase activity and total cholesterol) and hematology parameters were evaluated. Furthermore, histopathology study was carried out on heart tissues. Results: We found that there was no significant difference in oxidative stress parameters and biochemical parameters between the control group and the groups that received different amounts of borage extract. There were also no changes in histopathology study. In blood parameters, the level of erythrocytes, hematocrit and hemoglobin decreased to 50mg/kg, whereas the level of MCH and MCV decreased in high doses. Conclusion: This article suggested that borage did not cause significant damage to the heart tissue in mice model. In hematology factors, significant changes were observed in erythrocytes and related parameters. Therefore, hematotoxicity of consumption this plant should be considered at high doses.

scholarly journals Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats

2021 ◽  
Vol 410 ◽  
pp. 115351
Author(s):  
Prasada Rao S. Kodavanti ◽  
Matthew Valdez ◽  
Judy E. Richards ◽  
Datonye I. Agina-Obu ◽  
Pamela M. Phillips ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Middle Age ◽  
Brain Regions ◽  
Brown Norway ◽  
Oxidative Stress Parameters ◽  
Induced Changes ◽  
Norway Rats ◽  
Stress Parameters

scholarly journals Physiological Effects of Deoxynivalenol from Naturally Contaminated Corn on Cerebral Tryptophan Metabolism, Behavioral Response, Gastrointestinal Immune Status and Health in Pigs Following a Pair-Feeding Model

Toxins ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 393
Author(s):  
Yan-Bin Shen ◽  
Alexandra C. Weaver ◽  
Sung Woo Kim
Keyword(s):  
Oxidative Stress ◽  
Immune Status ◽  
Feed Consumption ◽  
Brain Serotonin ◽  
Oxidative Stress Parameters ◽  
Immune Parameters ◽  
Dietary Treatments ◽  
The Impact ◽  
And Oxidative Stress ◽  
Stress Parameters

This study investigated the impact of deoxynivalenol (DON) from naturally contaminated feed on pig growth, immune status, organ health, brain serotonin (5-Hydroxytryptamine, 5-HT) and behavior. Sixteen individually housed pigs (25.57 ± 0.98 kg, age 9 weeks) were randomly allotted to two dietary treatments: without DON (CON) or with 3.8 mg/kg of DON (MT). Pigs were pair-fed to eliminate differences in feed intake (equal tryptophan (Trp) intake). Pigs fed CON received a daily ration based on the ad libitum feed consumption of their MT pair-mate. Performance was determined over 21 days and blood collected for immunological and oxidative stress parameters. Behavior was recorded for 12 h on days 0, 7, 14 and 21. After 21 days, pigs were euthanized to collect tissues for immune parameters, gut morphology and brain serotonin levels. Overall, pigs fed MT had greater weight gain compared with CON. Immunological and oxidative stress parameters were unaffected, but pigs fed MT had reduced villus height, crypt depth and villus-to-crypt ratio in the jejunum. Pigs consuming MT had reduced concentration of 5-HT and increased 5-HT turnover in the hypothalamus. Mycotoxin-fed pigs spent more time lying and sitting, and less time standing and drinking. In conclusion, consumption of DON impacted gastrointestinal tract structure, altered behavior and changed Trp metabolism through increasing 5-HT turnover in hypothalamus.

The impact of chronic exposure to air pollution over oxidative stress parameters and brain histology

2021 ◽  
Author(s):  
Rosane Bossle Bernardi ◽  
Ana Cláudia Tedesco Zanchi ◽  
Nilsa Regina Damaceno-Rodrigues ◽  
Mariana Matera Veras ◽  
Paulo Hilário Nascimento Saldiva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Air Pollution ◽  
Chronic Exposure ◽  
Oxidative Stress Parameters ◽  
The Impact ◽  
Stress Parameters

scholarly journals The Impact of Endometritis on Specific Oxidative Stress Parameters in Cows

2018 ◽  
Vol 68 (2) ◽  
pp. 231
Author(s):  
S. KAYA ◽  
M. ÖĞÜN ◽  
H. ÖZEN ◽  
M. KURU ◽  
L. ŞAHIN ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Control Group ◽  
Group Iii ◽  
Uterine Infection ◽  
Oxidative Stress Parameters ◽  
Group I ◽  
Early Postpartum ◽  
Total Antioxidant ◽  
The Impact ◽  
Stress Parameters

This study was aimed to investigate the presence of uterine infection and the relationship between the severity of uterine infection and some oxidative stress parameters in cows in early postpartum period. Sixty six cows that were in the period between the 30th and 32rd days of postpartum were included in the study. Endometrial inflammation was scored according to the condition of the uterus at rectal and ultrasonographic examinations and the character and amount of uterine discharge from endometritis I through III, the latest being the most severe. Endometrial samples were taken from the clinically healthy animals by cytobrush method, and then stained with Giemsa for presence of polymorphonuclear leukocytes (PMN). Cows with a PMN percentage less than 18% were considered to be healthy (control, n=20). All cows were sampled for blood. Nitric oxide (NO) levels in Group I (Endometritis I; n=20), Group II (Endometritis II; n=16), Group III (Endometritis III; n=10) and the control group were determined to be 23.0±0.63 nmol/mL, 32.23±0.97 nmol/mL, 36.56±0.48 nmol/mL, and 11.10±0.29 nmol/mL, respectively. The differences among the groups were found to be statistically significant. Malondialdehyde (MDA) level was highest in Group III (6.38±0.13 μmol/L), and its level significantly decreased with the reduced severity of endometritis. The comparison of the groups for total antioxidant capacity (TAC) and total oxidant capacity (TOC) demonstrated that endometritis caused a decrease in TAC levels (P<0.05), but did not affect TOC levels. Endometritis increased serum NO and MDA levels, and decreased TAC levels, but had no effect on TOC levels. In conclusion, NO and MDA, as well as TAC can be used as a biochemical marker for estimation of the severity of endometritis in cows.

scholarly journals Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine and Oxidative Stress Parameters in Pregnant Women – the Pilot Study

2019 ◽  
Author(s):  
Lubica Argalasova ◽  
Ingrid Zitnanova ◽  
Diana Vondrova ◽  
Monika Dvorakova ◽  
Lucia Laubertova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Pregnant Women ◽  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Passive Smoking ◽  
Oxidative Stress Parameters ◽  
The Impact ◽  
And Oxidative Stress ◽  
Stress Parameters

Abstract: Background: Exposure to ETS (Environmental Tobacco Smoke) is one of the most toxic environmental exposures. Objective: To investigate the impact of ETS on physiological, biochemical, psychological indicators, on the urine antioxidant capacity (AC) and oxidative damage to lipids in a pilot sample of healthy pregnant women. Methods: The exposure to ETS was investigated by a validated questionnaire, urine cotinine and the marker of oxidative damage to lipids - 8-isoprostane concentrations using an ELISA kit. Urine AC was determined by the spectrophotometric TEAC method. From the sample of pregnant women (n=319, average age 30.84 ± 5.09 years) in 80 the levels of cotinine and oxidative stress markers were analyzed. Results: From our sample, 5 % individuals (7.4 % objectified by cotinine) were current smokers and 25 % reported passive smoking in the household (18.8 % objectified by cotinine). The Kappa was 0.78 for smokers and 0.22 for ETS exposed non-smokers. Smokers as well as non-smokers had significantly higher (p&lt;0.05) urine AC than ETS exposed non-smokers. Non-smokers had significantly lower levels of 8-isoprostane than smokers (p&lt;0.01) and ETS-exposed non-smokers (p&lt;0.05). Correlations between urine levels of cotinine and AC were positive in ETS exposed non-smokers. Conclusion: The harmful effect of active and passive smoking on oxidative stress parameters has been indicated.

Does human myocardium show a gender dependent modification of oxidative stress parameters?

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
K. Buschmann ◽  
Y. Gramlich ◽  
M. Oelze ◽  
A. Daiber ◽  
T. Münzel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Myocardium ◽  
Oxidative Stress Parameters ◽  
Dependent Modification ◽  
Stress Parameters
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