scholarly journals Protective effects of dantrolene and methylprednisolone against spinal cord injury-induced early oxidative damage in rabbit bladder: A comparative experimental study

2019 ◽  
Vol 28 (12) ◽  
pp. 1697-1704 ◽  
Author(s):  
ibrahim keles ◽  
Mehmet Bozkurt ◽  
Erdogan Aglamis ◽  
Abdurrahman Fidan ◽  
Cavit Ceylan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Experimental Study ◽  
Spinal Cord Injury ◽  
Oxidative Damage ◽  
Protective Effects ◽  
Cord Injury ◽  
Rabbit Bladder

scholarly journals Experimental study on the protective effects of edaravone against ischemic spinal cord injury

2005 ◽  
Vol 130 (6) ◽  
pp. 1586-1592 ◽  
Author(s):  
Kazuchika Suzuki ◽  
Teruhisa Kazui ◽  
Hitoshi Terada ◽  
Kazuo Umemura ◽  
Yasuhiko Ikeda ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Experimental Study ◽  
Spinal Cord Injury ◽  
Protective Effects ◽  
Cord Injury ◽  
Ischemic Spinal Cord Injury

Protective effects of melatonin against spinal cord injury induced oxidative damage in rat kidney: A morphological and biochemical study

2013 ◽  
Vol 115 (8) ◽  
pp. 827-834 ◽  
Author(s):  
Dilek Akakin ◽  
Demir Kiran ◽  
Naziye Ozkan ◽  
Mehmet Erşahin ◽  
Zarife Nigar Ozdemir-Kumral ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Oxidative Damage ◽  
Biochemical Study ◽  
Rat Kidney ◽  
Protective Effects ◽  
Cord Injury

Protective Effects of Zinc on Spinal Cord Injury

2021 ◽  
Author(s):  
Shan Wen ◽  
Yuanlong Li ◽  
Xiaolei Shen ◽  
Zhe Wang ◽  
Kaihua Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protective Effects ◽  
Cord Injury

scholarly journals Knockdown of long non-coding RNA LEF1-AS1 attenuates apoptosis and inflammatory injury of microglia cells following spinal cord injury

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Sheng-Yu Cui ◽  
Wei Zhang ◽  
Zhi-Ming Cui ◽  
Hong Yi ◽  
Da-Wei Xu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Viability ◽  
Microglial Cells ◽  
Protective Effects ◽  
Loss Of Function ◽  
Sprague Dawley ◽  
Cord Injury ◽  
Apoptosis And Inflammation

Abstract Background Spinal cord injury (SCI) is associated with health burden both at personal and societal levels. Recent assessments on the role of lncRNAs in SCI regulation have matured. Therefore, to comprehensively explore the function of lncRNA LEF1-AS1 in SCI, there is an urgent need to understand its occurrence and development. Methods Using in vitro experiments, we used lipopolysaccharide (LPS) to treat and establish the SCI model primarily on microglial cells. Gain- and loss of function assays of LEF1-AS1 and miR-222-5p were conducted. Cell viability and apoptosis of microglial cells were assessed via CCK8 assay and flow cytometry, respectively. Adult Sprague-Dawley (SD) rats were randomly divided into four groups: Control, SCI, sh-NC, and sh-LEF-AS1 groups. ELISA test was used to determine the expression of TNF-α and IL-6, whereas the protein level of apoptotic-related markers (Bcl-2, Bax, and cleaved caspase-3) was assessed using Western blot technique. Results We revealed that LncRNA LEF1-AS1 was distinctly upregulated, whereas miR-222-5p was significantly downregulated in LPS-treated SCI and microglial cells. However, LEF1-AS1 knockdown enhanced cell viability, inhibited apoptosis, as well as inflammation of LPS-mediated microglial cells. On the contrary, miR-222-5p upregulation decreased cell viability, promoted apoptosis, and inflammation of microglial cells. Mechanistically, LEF1-AS1 served as a competitive endogenous RNA (ceRNA) by sponging miR-222-5p, targeting RAMP3. RAMP3 overexpression attenuated LEF1-AS1-mediated protective effects on LPS-mediated microglial cells from apoptosis and inflammation. Conclusion In summary, these findings ascertain that knockdown of LEF1-AS1 impedes SCI progression via the miR-222-5p/RAMP3 axis.

scholarly journals Does dexmedetomidine reduce secondary damage after spinal cord injury? An experimental study

2009 ◽  
Vol 18 (3) ◽  
pp. 336-344 ◽  
Author(s):  
Adem Aslan ◽  
Mustafa Cemek ◽  
Olcay Eser ◽  
Korhan Altunbaş ◽  
Mehmet Emin Buyukokuroglu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Experimental Study ◽  
Spinal Cord Injury ◽  
Secondary Damage ◽  
Cord Injury
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