scholarly journals The Importance of Rehabilitation before and after Lung Transplantation

2017 ◽  
Vol 4 (2) ◽  
pp. e3-e5
Author(s):  
Masahiro Kohzuki ◽  
◽  
Yosuke Izoe ◽  
Taku Harada ◽  
◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Before And After

scholarly journals 1458. Uncharted territories: applying “precision medicine” to understand the treacherous landscape of extensively and multidrug resistant (XDR and MDR) Pseudomonas aeruginosa in a patient with cystic fibrosis and lung transplantation

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S731-S731
Author(s):  
Laura J Rojas ◽  
Mohamad Yasmin ◽  
Jacquelynn Benjamino ◽  
Steven Marshall ◽  
Kailynn DeRonde ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Lung Transplantation ◽  
Precision Medicine ◽  
Clinical Sample ◽  
Phylogenetic Reconstruction ◽  
Multidrug Resistant ◽  
Population Diversity ◽  
Before And After ◽  
Research Grant

Abstract Background Pseudomonas aeruginosa is a persistent and difficult-to-treat pathogen in many patients, especially those with cystic fibrosis (CF). Herein, we describe our experience managing a young woman suffering from CF with XDR P. aeruginosa who underwent lung transplantation. We highlight the contemporary difficulties reconciling the clinical, microbiological, and genetic information. Methods Mechanism-based-susceptibility disk diffusion synergy testing with double and triple antibiotic combinations aided in choosing tailored antimicrobial combinations to control the infection in the pre-transplant period, create an effective perioperative prophylaxis regimen, and manage recurrent infections in the post-transplant period. Thirty-six sequential XDR and PDR P. aeruginosa isolates obtained from the patient within a 17-month period, before and after a double-lung transplant were analyzed by whole genome sequencing (WGS) and RNAseq in order to understand the genetic basis of the observed resistance phenotypes, establish the genomic population diversity, and define the nature of sequence changes over time Results Our phylogenetic reconstruction demonstrates that these isolates represent a genotypically and phenotypically heterogeneous population. The pattern of mutation accumulation and variation of gene expression suggests that a group of closely related strains was present in the patient prior to transplantation and continued to evolve throughout the course of treatment regardless of antibiotic usage.Our findings challenge antimicrobial stewardship programs that assist with the selection and duration of antibiotic regimens in critically ill and immunocompromised patients based on single-isolate laboratory-derived resistant profiles. We propose that an approach sampling the population of pathogens present in a clinical sample instead of single colonies be applied instead when dealing with XDR P. aeruginosa, especially in patients with CF. Conclusion In complex cases such as this, real-time combination testing and genomic/transcriptomic data could lead to the application of true “precision medicine” by helping clinicians choose the combination antimicrobial therapy most likely to be successful against a population of MDR pathogens present. Disclosures Federico Perez, MD, MS, Accelerate (Research Grant or Support)Merck (Research Grant or Support)Pfizer (Research Grant or Support) Robert A. Bonomo, MD, Entasis, Merck, Venatorx (Research Grant or Support)

Pulmonary Hypertension in End-Stage Pulmonary Fibrosis: Prevalence, Predictors and Survival before and after Lung Transplantation

2013 ◽  
Vol 32 (4) ◽  
pp. S18-S19 ◽  
Author(s):  
L. Bjurström ◽  
K.H. Andersen ◽  
J. Kjærgaard ◽  
M.P. Iversen ◽  
S. Boesgaard ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Fibrosis ◽  
Lung Transplantation ◽  
Before And After ◽  
End Stage

Prospective Study of Functional Status and Quality of Life Before and After Lung Transplantation

CHEST Journal ◽  
2000 ◽  
Vol 118 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Dorothy M. Lanuza ◽  
Cheryl Lefaiver ◽  
Mary Mc Cabe ◽  
Gabriella A. Farcas ◽  
Edward Garrity
Keyword(s):  
Quality Of Life ◽  
Prospective Study ◽  
Lung Transplantation ◽  
Functional Status ◽  
Before And After

Quality of Life before and after Lung Transplantation in Patients with Emphysema versus other Indications

2001 ◽  
Vol 89 (3) ◽  
pp. 707-717 ◽  
Author(s):  
E. M. TenVergert ◽  
K. M. Vermeulen ◽  
A. Geertsma ◽  
P. J. van Enckevort ◽  
W. J. de Boer ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Transplantation ◽  
Nottingham Health Profile ◽  
Well Being ◽  
Health Profile ◽  
Health Related Quality ◽  
Before And After ◽  
Related Quality ◽  
Health Related

Whether lung transplantation improves Health-related Quality of Life in patients with emphysema and other end-stage lung diseases before and after lung transplantation was examined. Berween 1992 and 1999, 23 patients with emphysema and 19 patients with other indications completed self-administered questionnaires before lung transplantation, and at 4, 7, 13, and 25 mo. after transplantation. The questionnaire included the Nottingham Health Profile, the State-Trait Anxiety Inventory, the Self-rating Depression Scale, the Index of Well-being, the self-report Karnofsky Index, and four respiratory-specific questions. Neither before nor after transplantation were significant differences found on most dimensions of Health-related Quality of Life between patients with emphysema and other indications. Before transplantation, both groups report major restrictions on the dimensions Energy and Mobility of the Nottingham Health Profile, low experienced well-being, depressive symptoms, and high dyspnea. About 4 mo. after transplantation, most Health-related Quality of Life measures improved significantly in both groups. These improvements were maintained in the following 21 mo.

Gastroesophageal Reflux (Symptomatic and Silent): A Potentially Significant Problem in Patients With Cystic Fibrosis Before and After Lung Transplantation

2005 ◽  
Vol 24 (10) ◽  
pp. 1522-1529 ◽  
Author(s):  
Brenda M. Button ◽  
Stuart Roberts ◽  
Tom C. Kotsimbos ◽  
Bronwyn J. Levvey ◽  
Trevor J. Williams ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Gastroesophageal Reflux ◽  
Lung Transplantation ◽  
Significant Problem ◽  
Before And After

scholarly journals Four Cases of Rehabilitation before and after Lung Transplantation

2003 ◽  
Vol 40 (5) ◽  
pp. 293-301
Author(s):  
Nobuyoshi MORI ◽  
Yoko GOTO ◽  
Hajime KUROSAWA ◽  
Kayomi MATSUMOTO ◽  
Kazunori YOSHIDA ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Before And After

Energy Expenditure and Nutritional Status in Pediatric Patients before and after Lung Transplantation

2013 ◽  
Vol 163 (5) ◽  
pp. 1500-1502 ◽  
Author(s):  
Daina Kalnins ◽  
Paul B. Pencharz ◽  
Hartmut Grasemann ◽  
Melinda Solomon
Keyword(s):  
Energy Expenditure ◽  
Nutritional Status ◽  
Lung Transplantation ◽  
Pediatric Patients ◽  
Before And After
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