scholarly journals Tissue-specific response of protein oxidation in the grayling (Thymallus thymallus L.) disinfected by chloramine-T

2015 ◽  
Vol 1 (1) ◽  
pp. 76-82 ◽  
Author(s):  
G.M. Tkachenko ◽  
J. Grudniewska
Keyword(s):  
Protein Oxidation ◽  
Specific Response ◽  
Thymallus Thymallus ◽  
Tissue Specific ◽  
Chloramine T

Corticosterone tissue-specific response in Sprague Dawley rats under acute heat stress

2019 ◽  
Vol 81 ◽  
pp. 12-19 ◽  
Author(s):  
Jinhuan Dou ◽  
Yuri R. Montanholi ◽  
Zezhao Wang ◽  
Zhongshu Li ◽  
Ying Yu ◽  
...  
Keyword(s):  
Heat Stress ◽  
Specific Response ◽  
Sprague Dawley ◽  
Tissue Specific ◽  
Sprague Dawley Rats ◽  
Acute Heat Stress

scholarly journals Akt3 Regulates the Tissue-Specific Response to Copaiba Essential Oil

2020 ◽  
Vol 21 (8) ◽  
pp. 2851
Author(s):  
Yasuyo Urasaki ◽  
Cody Beaumont ◽  
Jeffery N. Talbot ◽  
David K. Hill ◽  
Thuc T. Le
Keyword(s):  
Essential Oil ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Liver Cells ◽  
Mtor Signaling ◽  
Specific Response ◽  
Mtor Signaling Pathway ◽  
Tissue Specific ◽  
Regulatory Effects ◽  
Specific Regulation

This study reports a relationship between Akt3 expression and tissue-specific regulation of the pI3K/Akt/mTOR signaling pathway by copaiba essential oil. Akt3, a protein kinase B isoform important for the regulation of neuronal development, exhibited differential expression levels in cells of various origins. In neuronal and microglial cells, where Akt3 is present, copaiba essential oil positively regulated the pI3K/Akt/mTOR signaling pathway. In contrast, in liver cells and T lymphocytes, where Akt3 is absent, copaiba essential oil negatively regulated the pI3K/Akt/mTOR signaling pathway. The expression of Akt3 via plasmid DNA in liver cells led to positive regulatory effects by copaiba essential oil on the pI3K/Akt/mTOR signaling pathway. In contrast, inhibition of Akt3 expression in neuronal cells via small interfering RNA molecules targeting Akt3 transcripts abrogated the regulatory effects of copaiba essential oil on the pI3K/Akt/mTOR signaling pathway. Interestingly, Akt3 expression did not impact the regulatory effects of copaiba essential oil on other signaling pathways. For example, copaiba essential oil consistently upregulated the MAPK and JAK/STAT signaling pathways in all evaluated cell types, independent of the Akt3 expression level. Collectively, the data indicated that Akt3 expression was required for the positive regulatory effects of copaiba essential oil, specifically on the pI3K/Akt/mTOR signaling pathway.

scholarly journals Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment

2019 ◽  
Vol 117 (1) ◽  
pp. 779-786 ◽  
Author(s):  
Gal Manella ◽  
Rona Aviram ◽  
Nityanand Bolshette ◽  
Sapir Muvkadi ◽  
Marina Golik ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Ex Vivo ◽  
Acute Hypoxia ◽  
Time Of Day ◽  
Chronic Obstructive ◽  
Specific Response ◽  
Dependent Manner ◽  
Tissue Specific ◽  
Circadian Misalignment ◽  
Obstructive Sleep

The occurrence and sequelae of disorders that lead to hypoxic spells such as asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea (OSA) exhibit daily variance. This prompted us to examine the interaction between the hypoxic response and the circadian clock in vivo. We found that the global transcriptional response to acute hypoxia is tissue-specific and time-of-day–dependent. In particular, clock components differentially responded at the transcriptional and posttranscriptional level, and these responses depended on an intact circadian clock. Importantly, exposure to hypoxia phase-shifted clocks in a tissue-dependent manner led to intertissue circadian clock misalignment. This differential response relied on the intrinsic properties of each tissue and could be recapitulated ex vivo. Notably, circadian misalignment was also elicited by intermittent hypoxia, a widely used model for OSA. Given that phase coherence between circadian clocks is considered favorable, we propose that hypoxia leads to circadian misalignment, contributing to the pathophysiology of OSA and potentially other diseases that involve hypoxia.

Tissue specific response to DNA damage: C. elegans as role model

DNA Repair ◽  
2015 ◽  
Vol 32 ◽  
pp. 141-148 ◽  
Author(s):  
Hannes Lans ◽  
Wim Vermeulen
Keyword(s):  
Dna Damage ◽  
Role Model ◽  
Specific Response ◽  
Tissue Specific ◽  
C Elegans

scholarly journals Tissue-Specific Response to Interstitial Angiotensin II in Humans

Hypertension ◽  
2003 ◽  
Vol 41 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Michael Boschmann ◽  
Jens Jordan ◽  
Frauke Adams ◽  
Niels-Juel Christensen ◽  
Jens Tank ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Specific Response ◽  
Tissue Specific

Tissue-specific response of estrogen receptor gene expression to estrogen in chick

1992 ◽  
Vol 187 (3) ◽  
pp. 1374-1380 ◽  
Author(s):  
Yuichi Ninomiya ◽  
Makoto Mochii ◽  
Goro Eguchi ◽  
Tadao Hasegawa ◽  
Shoichi Masushige ◽  
...  
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Receptor Gene ◽  
Specific Response ◽  
Estrogen Receptor Gene ◽  
Tissue Specific ◽  
Receptor Gene Expression
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