Roles for activator protein 2 (AP-2) transcription factors in zebrafish neural crest development

2008 ◽  
Author(s):  
Wei Li
Keyword(s):  
Transcription Factors ◽  
Neural Crest ◽  
Activator Protein ◽  
Neural Crest Development ◽  
Activator Protein 2

The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos

Development ◽  
2001 ◽  
Vol 128 (8) ◽  
pp. 1467-1479 ◽  
Author(s):  
R. Kos ◽  
M.V. Reedy ◽  
R.L. Johnson ◽  
C.A. Erickson
Keyword(s):  
Transcription Factors ◽  
Neural Crest ◽  
Antisense Oligonucleotides ◽  
Neural Crest Cells ◽  
Winged Helix ◽  
Dorsal Neural Tube ◽  
Neural Crest Development ◽  
Mesenchymal Transformation ◽  
Winged Helix Transcription Factor

The winged-helix or forkhead class of transcription factors has been shown to play important roles in cell specification and lineage segregation. We have cloned the chicken homolog of FoxD3, a member of the winged-helix class of transcription factors, and analyzed its expression. Based on its expression in the dorsal neural tube and in all neural crest lineages except the late-emigrating melanoblasts, we predicted that FoxD3 might be important in the segregation of the neural crest lineage from the neural epithelium, and for repressing melanogenesis in early-migrating neural crest cells. Misexpression of FoxD3 by electroporation in the lateral neural epithelium early in neural crest development produced an expansion of HNK1 immunoreactivity throughout the neural epithelium, although these cells did not undergo an epithelial/mesenchymal transformation. To test whether FoxD3 represses melanogenesis in early migrating neural crest cells, we knocked down expression in cultured neural crest with antisense oligonucleotides and in vivo by treatment with morpholino antisense oligonucleotides. Both experimental approaches resulted in an expansion of the melanoblast lineage, probably at the expense of neuronal and glial lineages. Conversely, persistent expression of FoxD3 in late-migrating neural crest cells using RCAS viruses resulted in the failure of melanoblasts to develop. We suggest that FoxD3 plays two important roles in neural crest development. First, it is involved in the segregation of the neural crest lineage from the neuroepithelium. Second, it represses melanogenesis, thereby allowing other neural crest derivatives to differentiate during the early stages of neural crest patterning.

scholarly journals Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2overexpression in breast cancer cell lines

2009 ◽  
Vol 11 (6) ◽  
Author(s):  
Grégory Nolens ◽  
Jean-Christophe Pignon ◽  
Benjamin Koopmansch ◽  
Benaïssa Elmoualij ◽  
Willy Zorzi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factors ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Activator Protein ◽  
Ku Proteins ◽  
Activator Protein 2

Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution

2007 ◽  
Vol 308B (5) ◽  
pp. 679-691 ◽  
Author(s):  
Trevor L. Hoffman ◽  
Anna L. Javier ◽  
Shelley A. Campeau ◽  
Robert D. Knight ◽  
Thomas F. Schilling
Keyword(s):  
Transcription Factors ◽  
Neural Crest ◽  
Neural Crest Development

scholarly journals Discovery of transcription factors and other candidate regulators of neural crest development

2008 ◽  
Vol 237 (4) ◽  
pp. 1021-1033 ◽  
Author(s):  
Meghan S. Adams ◽  
Laura S. Gammill ◽  
Marianne Bronner-Fraser
Keyword(s):  
Transcription Factors ◽  
Neural Crest ◽  
Neural Crest Development
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