scholarly journals Serum level of AGE/RAGE as a potential biomarker for acute stroke

2015 ◽  
Vol 26 (2) ◽  
pp. 51-56
Author(s):  
Chiaki Yokota
Keyword(s):  
Serum Level ◽  
Acute Stroke ◽  
Potential Biomarker

scholarly journals Evaluation of urinary and serum level of chemokine (C‐C motif) ligand 2 as a potential biomarker in canine urothelial tumours

2018 ◽  
Vol 17 (1) ◽  
pp. 11-20 ◽  
Author(s):  
N. Shimizu ◽  
A. Hamaide ◽  
M. Dourcy ◽  
S. Noël ◽  
C. Clercx ◽  
...  
Keyword(s):  
Serum Level ◽  
Potential Biomarker ◽  
Urothelial Tumours

scholarly journals Serum Level of Antibodies (IgG, IgM) Against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in Children Dermatologically Exposed to Coal Tar

2017 ◽  
Vol 60 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Pavel Borský ◽  
Ctirad Andrýs ◽  
Jan Krejsek ◽  
Květoslava Hamáková ◽  
Jan Kremláček ◽  
...  
Keyword(s):  
Immune Response ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Serum Level ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Coal Tar ◽  
Reactive Metabolite ◽  
Potential Biomarker ◽  
Polycyclic Aromatic ◽  
Dermal Application

Crude coal tar (CCT) contains polycyclic aromatic hydrocarbons (PAHs). Benzo[a]pyrene (BaP) is metabolized into a highly reactive metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) that is able to bind to DNA and creates BPDE-DNA adducts. Adducted DNA becomes immunogenic and induces immune response by production of antibodies against BPDE-DNA adducts (Ab-BPDE-DNA). Circulating Ab-BPDE-DNA was proposed as potential biomarker of genotoxic exposure to BaP (PAHs). Goeckerman therapy (GT) of psoriasis uses dermal application of CCT ointment (PAHs). In presented study (children with psoriasis treated by GT; n = 19) the therapy significantly increased the level of Ab-BPDE-DNA (EI = 0.29/0.19–0.34 vs. 0.31/0.25–0.40; median/lower–upper quartile; p < 0.01). The results support the idea of Ab-BPDE-DNA level as a possible tentative indicator of exposure, effects and susceptibility of the organism to the exposure of BaP (PAHs).

Cortical connectivity from EEG data in acute stroke: A study via graph theory as a potential biomarker for functional recovery

2019 ◽  
Vol 146 ◽  
pp. 133-138 ◽  
Author(s):  
Fabrizio Vecchio ◽  
Carlo Tomino ◽  
Francesca Miraglia ◽  
Francesco Iodice ◽  
Carmen Erra ◽  
...  
Keyword(s):  
Graph Theory ◽  
Acute Stroke ◽  
Functional Recovery ◽  
Cortical Connectivity ◽  
Potential Biomarker ◽  
Eeg Data

scholarly journals Evaluation of Interleukin-2 to Detect Active and Latent Tuberculosis among Household Contacts of Pulmonary Tuberculosis Cases

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Azadeh Jafrasteh ◽  
Abdollah Karimi ◽  
Seyedeh Mahsan Hoseinialfatemi ◽  
Leila Azimi ◽  
Payam Tabarsi ◽  
...  
Keyword(s):  
Serum Level ◽  
Active Form ◽  
Interleukin 2 ◽  
Clinical Manifestations ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Laboratory Findings ◽  
Household Contacts ◽  
Potential Biomarker

Background: The interferon-gamma release assays (IGRAs) are the most important diagnostic approach to Mycobacterium tuberculosis infection diagnosis. However, they cannot discriminate between latent tuberculosis infection (LTBI) and active tuberculosis (TB). Some recent studies suggested that interleukin-2 (IL-2) response to M. tuberculosis could be utilized as a potential biomarker to discriminate active disease from LTBI. Objectives: The current study aimed at evaluating the potential role of IL-2 to detect both active TB and LTBI among household contacts of patients with pulmonary TB in two TB-endemic regions of Iran. Methods: A total of 650 household contacts of patients with TB were invited to participate in the current study. All subjects were diagnosed on extensive clinical evaluation of active TB and LTBI based on clinical manifestations and laboratory findings. The IGRA test was performed using QuantiFERON®-TB Gold Plus. The serum level of IL-2 was measured using the ELISA Development Kit. Results: A total of 237 household contacts entered the final analysis, including 132 patients with LTBI and three with active TB. In addition, 14 subjects were included as TB controls and 102 as TB-uninfected controls. The serum level of IL-2 was significantly higher in active TB and LTBI patients than TB-uninfected controls. The ROC curve was plotted between active TB and LTBI, revealing that the cutoff point of 25.5 pg/mL identifies the active form with 88.24% sensitivity and 36.36% specificity. Conclusions: The current study indicated that the IL-2 assay could not discriminate between active TB and LTBI with acceptable sensitivity.

scholarly journals Serum Level and Tumor Tissue Expression of Ribonucleotide-Diphosphate Reductase Subunit M2 B: A Potential Biomarker for Colorectal Cancer

2021 ◽  
Author(s):  
Naser Mobarra ◽  
Hanieh Gholamalizadeh ◽  
Kaed A. Abdulhussein ◽  
Fatemeh Taheri Asl ◽  
Mobina Sadat Mirvahabi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Serum Level ◽  
Tumor Metastasis ◽  
Tumor Tissue ◽  
Tumor Staging ◽  
Tissue Expression ◽  
Control Group ◽  
Potential Biomarker ◽  
The Mean ◽  
First Time

Abstract Background: This study aimed to investigate whether serum level and tissue expression of Ribonucleotide-diphosphate Reductase subunit M2 B (RRM2B) could be recognized as reliable biomarkers for colorectal cancer (CRC) progression and metastasis.Methods and Results: This descriptive-analytic cohort study was conducted on 50 newly diagnosed CRC patients (stage II, III) and 50 healthy individuals. The new cases had not received any therapeutic intervention and underwent surgery immediately after the initial diagnosis. Tumorous tissues and marginal healthy tissues as control were excised to determine the mRNA tissue expression of RRM2B by Real-Time PCR. Serum RRM2B protein was measured using an ELISA method once in the control group and in the patients before, one, and three months after surgery. The tumor metastasis node (TMN) classification system and liver metastasis were evaluated in CRC patients. The mean RRM2B gene expression in tumor tissue was 51% lower than adjacent normal tissue (P < 0.001). We did not find a significant relationship between serum level of RRM2B and tumor staging and metastasis in patients before surgery (P = 0.373, P = 0.189), one month after surgery (P = 0.960, P = 0.088), and three months after surgery (P = 0.407, P = 0.724). RRM2B expression in tumor tissue was not associated with tumor staging and metastasis (P = 0.254, P = 0.721)Conclusion: Our study indicates the first time evidence that RRM2B may serve as a potential biomarker for CRC.

scholarly journals Serum AFU, 5’-NT and AFP as biomarkers for primary hepatocellular carcinoma diagnosis

Open Medicine ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 354-358 ◽  
Author(s):  
Zhu Junna ◽  
Chen Gongde ◽  
Xu Jinying ◽  
Zhou Xiu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Level ◽  
Roc Curve ◽  
Diagnostic Sensitivity ◽  
Primary Hepatocellular Carcinoma ◽  
Control Group ◽  
Healthy Controls ◽  
Clinical Value ◽  
Potential Biomarker ◽  
Healthy Control

AbstractTo evaluate the clinical value of serum α-L-fucosidase (AFU), 5’-nucleotidase (5’-NT) and alpha fetoprotein (AFP) as biomarkers for primary hepatocellular carcinoma (PHC) diagnosis. Methods: Thirty six primary hepatocellular carcinoma (PHC) patients and 36 healthy controls were recruited in this study from February 2014 to January 2016 in the Second People’s Hospital of Tianjin. The serum level of AFU, 5’-NT and AFP were examined and compared between the two groups. The diagnostic sensitivity, specificity area under the receiver operating characteristic (ROC) curve were calculated by STATA11.0 software. Results: The serum level of AFU, 5’-NT, AFP were 30.87±10.43(U/L), 5.58±3.89(U/L), 233.60±226.60 (μg/L) respectively for primary hepatocellular carcinoma group and 19.96±6.73 (U/L), 1.87±0.84 (U/L), 16.64±14.17 (μg/L) for healthy control groups. The serum level of AFU, 5’-NT and AFP in primary hepatocellular carcinoma group were significant higher than those of healthy control group (P<0.001). The diagnostic sensitivity and specificity were 0.78 (95%CI:l0.61-0.90), 0.64 (95%CI:0.46-0.79) for serum AFU, 0.75(95%CI:0.58-0.88), 0.72(95%CI:0.55- 0.86) for serum 5’-NT and 0.72 (95%CI:0.55-0.86), 0.92 (95%CI:0.78-0.98) for serum AFP respectively. The AUC under the ROC curve were 0.80 (0.69-0.90), 0.80 (0.69-0.91) and 0.87 (0.780-0.96) for serum AFU, 5’-NT and AFP respectively. Positive correlation between AFU and 5’-NT (rpearson=0.63, P<0.05), AFU and AFP (rpearson=0.49, P<0.05), 5’-NT and AFP(rpearson=0.44, P<0.05) were found in the primary hepatocellular carcinoma patients. Conclusion: Serum AFU, 5’-NT and AFP were higher in PHC patients than those of healthy controls. The difference between PHC patients and healthy controls made serum AFU, 5’-NT and AFP potential biomarker for PHC diagnosis.

scholarly journals Serum vitamin D levels in acute stroke patients

2019 ◽  
Vol 55 (1) ◽  
Author(s):  
Fayrouz O. Selim ◽  
Rasha M. Fahmi ◽  
Ayman E. Ali ◽  
Nermin Raafat ◽  
Ahmed F. Elsaid
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Acute Stroke ◽  
Vitamin D Deficiency ◽  
Control Group ◽  
Cerebral Stroke ◽  
Stroke Severity ◽  
Stroke Outcome ◽  
Stroke Patients ◽  
Vitamin D Levels

Abstract Background Vitamin D deficiency has been proposed as a risk factors of cerebrovascular stroke. Objectives The aim of this study was firstly, to assess the serum level of vitamin D in cerebral stroke patients and secondly, to examine if its deficiency was associated with stroke severity and outcome. Methods We utilized a case-control study design and recruited 138 acute stroke patients and 138 age- and sex-matched controls from subjects attending outpatient clinic for other reasons. All participants were subjected to full general and neurological examination. Brain imaging CT and/or MRI was performed. Blood samples were collected for measurement of serum level of vitamin D (ng/ml) by ELISA, alkaline phosphatase, serum calcium, and phosphorous. The stroke severity was assessed by the National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was assessed by modified Rankin Scale (mRS). Results Stroke patients had significant lower levels of vitamin D compared with the control group. Vitamin D deficiency remained significantly associated with the NIHSS stroke severity score and the mRS 3-month stroke outcome after controlling for other significant factors such as age, dyslipidemia, and infarction size using multivariable logistic regression analysis. Conclusion Our results demonstrated that stroke patients suffer from vitamin D deficiency, which was associated with both stroke severity and poor outcome. Vitamin D supplementation could exert a therapeutic role in the management of cerebral stroke.

scholarly journals Serum level of nerve growth factor is a potential biomarker of conversion to bipolar disorder in women with major depressive disorder

2019 ◽  
Vol 73 (9) ◽  
pp. 590-593 ◽  
Author(s):  
Fernanda Pedrotti Moreira ◽  
Taiane C. Cardoso ◽  
Thaíse C. Mondin ◽  
Carolina D. Wiener ◽  
Luciano D. de Mattos Souza ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Serum Level ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Nerve Growth ◽  
Potential Biomarker

Serum level of ANGPTL4 as a potential biomarker in renal cell carcinoma

2017 ◽  
Vol 35 (5) ◽  
pp. 279-285 ◽  
Author(s):  
Dong Dong ◽  
Li Jia ◽  
Yunli Zhou ◽  
Li Ren ◽  
Juan Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Serum Level ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Potential Biomarker
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