EVALUATION OF HISTOPATHOLOGICAL AND BIOCHEMICAL CHANGES OF TAMRA BHASMA (A COPPER BASED MINERAL FORMULATION) REPEATED DOSE TOXICITY STUDY IN WISTAR ALBINO RATS

2016 ◽  
Vol 4 (4.3) ◽  
pp. 3246-3252
Author(s):  
Ravi Bhaskar ◽  
◽  
Doshi. M.A ◽  
Shakunthala. R.Pai ◽  
Ravishankar. B ◽  
...  
Keyword(s):  
Biochemical Changes ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Albino Rats ◽  
Repeated Dose Toxicity ◽  
Wistar Albino Rats

scholarly journals Acute and Repeated Dose Toxicity Study of Clevira Syrup – A Polyherbal Formulation

2021 ◽  
Vol 14 (3) ◽  
pp. 1459-1467
Author(s):  
Uma Narayanamurthy ◽  
Mirunalini .R ◽  
Subha. V ◽  
K. Manimekalai ◽  
Sakthibalan K ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Toxicity Study ◽  
Tinospora Cordifolia ◽  
Repeated Dose ◽  
Piper Nigrum ◽  
Albino Rats ◽  
Polyherbal Formulation ◽  
Acute Toxicity Study ◽  
Repeated Dose Toxicity ◽  
Wistar Albino Rats

Aim and Objectives: This study evaluated the acute and repeated dose toxicity effects of Clevira Syrup Polyherbal formulation (CSPHF), which was prepared from ten different herbs, well known and widely used in traditional medicine for the management of viral infections and other inflammatory disease conditions. Individually these herbs (Carica papaya, Melia azedarach, Andrographis paniculata, Vetiveria zizanioides, Trichosanthes dioica, Cyperus rotundus, Zingiber officinale, Piper nigrum, Mollugo Cerviana and Tinospora cordifolia )were completely safe, but the polyherbal formulation effects were not known. Thus, this study was done for the investigation of toxicological profile of CSPHF in Wistar Albino rats. Methods: As per OECD(Organisation for Economic Co-operation and Development) guidelines 423 and 407, Acute and Repeated dose toxicity study were proceeded. In the acute toxicity study a single dose of CSPHF (2000mg/kg) was administered orally to female Wistar rats and in repeated dose toxicity study, CSPHF was administered orally in Control group and three different doses (1000, 500 and 250mg/kg body weight) to both male and female wistar albino rats for 28 days. At the end of the study, the animals were euthanized, observed the external and internal morphology (Acute Toxicity) and assessed the effect of CSPHF on histopathological and biochemical parameters (Repeated Dose toxicity study). Results: In acute toxicity study, there were no visual signs of toxicity of CSPHF (2000mg/kg) observed, whereas in Repeated dose toxicity study Ischaemia, inflammation and hematoma of the internal organs were observed at 1000mg/kg dose, but no such toxic features were seen at 500 and 250mg/kg dose of CSPHF. Conclusion: The results of the Acute and Repeated Dose toxicity study could be authenticated in future studies, which will be more useful and evidence based for the management of Viral infectionsduring pandemics.

scholarly journals Evaluation of Safety of Karnasphota (Cardiospermum halicacabum L.) Leaf through Acute Oral Toxicity Study and Repeated Dose: 28-day Oral Toxicity Study in Wistar Albino Rats

2018 ◽  
Vol 3 (1) ◽  
pp. 15-22
Author(s):  
Sudesh N Gaidhani ◽  
Kandiyoor R Surabhi ◽  
Yalwar R Sanjayakumar ◽  
Paravazhi Radhakrishnan ◽  
Natarajan Thamizhselvam ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Albino Rats ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Wistar Albino Rats

Effects of Various Levels of Dietary Lepidium Sativum L. Seeds in Rats

1999 ◽  
Vol 27 (03n04) ◽  
pp. 397-405 ◽  
Author(s):  
S. E. I. Adam
Keyword(s):  
Growth Rate ◽  
Traditional Medicine ◽  
Total Protein ◽  
Toxicity Study ◽  
Lepidium Sativum ◽  
Albino Rats ◽  
Wistar Albino Rats ◽  
Lepidium Sativum L

A toxicity study was made on Lepidium sativum L. seeds used in Saudi traditional medicine for the treatment of various ailments. Lepidium sativum L. seed fed to Wistar albino rats at 2% (w/w) was non-toxic, Ten percent (w/w) was toxic but not fatal and 50% (w/w) of the diet for 6 weeks was lethal and caused depression in growth rate and entero-hepato-nephrotoxicity. Organ lesions accompanied by anemia and leukopenia were correlated with alterations in serum AST and ALT activities and concentrations of total protein, cholesterol, urea, and other serum constituents.

Acute and a 28-day repeated-dose toxicity study of total flavonoids from Clinopodium chinense (Benth.) O. Ktze in mice and rats

2017 ◽  
Vol 91 ◽  
pp. 117-123 ◽  
Author(s):  
Yonglin Gao ◽  
Yunzhi Wang ◽  
Kezhou Wang ◽  
Jing Zhu ◽  
Guisheng Li ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Total Flavonoids ◽  
Repeated Dose Toxicity

scholarly journals A FIFTY TWO-WEEK ORAL REPEATED DOSE TOXICITY STUDY OF SUPLATAST TOSILATE (IPD-1151T) IN DOGS

1992 ◽  
Vol 17 (SupplementII) ◽  
pp. 101-139
Author(s):  
Michiko AOKI ◽  
Tsuneo OHTAKI ◽  
Takayuki SEKI ◽  
Koichi KOJIMA ◽  
Shinsuke YOSHIMURA ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Repeated Dose Toxicity

Subchronic toxicological evaluation of Bojungikki-tang water extract: 13-Week oral repeated-dose toxicity study in Crl:CD (SD) rats

2020 ◽  
Vol 252 ◽  
pp. 112551
Author(s):  
Woo-Young Jeon ◽  
Chang-Seob Seo ◽  
Hyekyung Ha ◽  
Hyeun-Kyoo Shin ◽  
Jae-Woo Cho ◽  
...  
Keyword(s):  
Water Extract ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Toxicological Evaluation ◽  
Sd Rats ◽  
Repeated Dose Toxicity

Four-week intravenous repeated dose toxicity study of vitacamphorae injection in rats

2020 ◽  
Vol 393 (10) ◽  
pp. 2001-2007 ◽  
Author(s):  
Yazhi Yuan ◽  
Mei Su ◽  
Jing Liu ◽  
Yajing Lou ◽  
Yufeng Xia ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Repeated Dose Toxicity

scholarly journals A SIX-MONTH INTRAVENOUS REPEATED DOSE TOXICITY STUDY OF TAZOB ACTAM/PIPERACILLIN AND TAZOBACTAM IN DOGS

1994 ◽  
Vol 19 (SupplementII) ◽  
pp. 177-197 ◽  
Author(s):  
Taiji HAYASHI ◽  
Hideaki YADA ◽  
Malcolm BLAIR ◽  
Kathryn A. LAUGHLIN ◽  
Gary Lee BLANCHARD ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Repeated Dose Toxicity
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