scholarly journals Evaluation of serum nitric oxide level and its relationship with disease activity parameters in patients with rheumatoid arthritis

2020 ◽  
Vol 10 (3) ◽  
pp. 297-301
Author(s):  
Hülya DEVECİ ◽  
Zeliha Cansel ÖZMEN
Keyword(s):  
Rheumatoid Arthritis ◽  
Nitric Oxide ◽  
Disease Activity ◽  
Nitric Oxide Level

Nitric oxide level and superoxide dismutase activity in serum of patients with rheumatoid arthritis

2003 ◽  
Vol 15 (4) ◽  
pp. 429-434 ◽  
Author(s):  
Seyithan Taysi ◽  
Zuhal Umudum ◽  
Refik Ali Sari ◽  
Sevinc Kuskay ◽  
Nuri Bakan
Keyword(s):  
Rheumatoid Arthritis ◽  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Superoxide Dismutase Activity ◽  
Nitric Oxide Level

AB0506 Study of Serum Nitric Oxide Level in Patients with Lupus Nephritis and Its Relation to Disease Activity

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 974.1-974
Author(s):  
A. Elzawawy ◽  
M. El bordiny ◽  
I. Abdelghany ◽  
I. Khalil ◽  
N. Baddor
Keyword(s):  
Nitric Oxide ◽  
Lupus Nephritis ◽  
Disease Activity ◽  
Nitric Oxide Level

scholarly journals Higher nitric oxide levels are associated with disease activity in Egyptian rheumatoid arthritis patients

2014 ◽  
Vol 54 (6) ◽  
pp. 446-451
Author(s):  
Adel Mahmoud Ali ◽  
Reem Abdelmonem Habeeb ◽  
Noran Osama El-Azizi ◽  
Dina Aziz Khattab ◽  
Rania Ahmed Abo-Shady ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Nitric Oxide ◽  
Disease Activity

scholarly journals Nitric Oxide: Link between Inflammation and Endothelial Dysfunction in Rheumatoid Arthritis

2016 ◽  
Vol 26 (03) ◽  
pp. 165-169 ◽  
Author(s):  
Nidhi Garg ◽  
Ashit Syngle ◽  
Pawan Krishan
Keyword(s):  
Rheumatoid Arthritis ◽  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Disease Activity ◽  
Proinflammatory Cytokines ◽  
Inflammatory Disease ◽  
No Production ◽  
Tnf Α ◽  
Relationship Of ◽  
The Relationship

AbstractNitric oxide (NO) plays an important role in inflammatory joint disease and endothelial function. Endothelial dysfunction has been attributed to a reduction in NO bioactivity in rheumatoid arthritis (RA). However, the relationship of NO with inflammation and endothelial dysfunction in RA has not yet been investigated.To investigate the relationship of nitrite with inflammation and endothelial dysfunction in RA.Total 28 patients satisfying 2010 Rheumatoid Arthritis Classification Criteria were recruited for the study. Serum nitrite estimation was performed by Griess reaction. Flow-mediated dilation (FMD) assessed using AngioDefender. Inflammatory disease activity measures included disease activity score of 28 joints (DAS28), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Proinflammatory cytokines (TNF-α, IL-6, and IL-1) measured using standard ELISA kits. Twenty-five healthy controls matched for age and sex were included for comparison.The serum nitrite level in patients with RA was markedly elevated as compared with controls (p < 0.05). FMD was significantly impaired in RA patients than controls (p < 0.05). DAS28 was significantly higher in RA patients (p < 0.05). Levels of ESR, CRP, TNF-α, IL-1, and IL-6 were significantly higher in RA patients than controls (p < 0.05). Significant positive correlation was observed between nitrite and CRP (r = 0.46, p < 0.05), TNF-α (r = 0.53, p < 0.05), and inverse correlation with FMD (r =0.62, p < 0.05).Inflammatory disease activity and endothelial dysfunction in RA are associated with increased concentration of proinflammatory cytokines and NO. Inflammatory triggered release of cytokines induced NO production that mediates endothelial dysfunction. These findings suggest a role for NO in inflammation-induced endothelial dysfunction in RA.

scholarly journals Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients.

1996 ◽  
Vol 184 (3) ◽  
pp. 1173-1178 ◽  
Author(s):  
E W St Clair ◽  
W E Wilkinson ◽  
T Lang ◽  
L Sanders ◽  
M A Misukonis ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Nitric Oxide ◽  
Disease Activity ◽  
Mononuclear Cells ◽  
Normal Subjects ◽  
Blood Mononuclear Cells ◽  
Nitrite Nitrate ◽  
Nos2 Expression

Nitric oxide (NO) is an important inflammatory mediator in nonhuman animal models of rheumatoid arthritis (RA). The purpose of the present study was to determine whether blood mononuclear cells from patients with active RA (as compared to control subjects) have higher levels of NO synthase type 2 (NOS2) and produce more NO in vitro. Leukocytes from 25 RA patients and 20 normal subjects were examined. Arthritis activity was assessed by tender and swollen joint counts, duration of morning stiffness, patient assessment of pain, physician and patient global assessment of disease activity, the modified Stanford Health Assessment Questionnaire, and by blood levels of acute phase reactants. Blood mononuclear cell NOS enzyme activity/antigen content and nitrite/nitrate formation in vitro were measured. Blood mononuclear cells from RA patients had increased NOS activity and increased NOS2 antigen content as compared to those from normal subjects, and responded to interferon-gamma with increased NOS expression and nitrite/nitrate production in vitro. NOS activity of freshly isolated blood mononuclear cells correlated significantly with disease activity, as assessed by render and swollen joint counts. Our results demonstrate that patients with RA have systemic activation for NOS2 expression, and that the degree of activation correlates with disease activity. Increased NOS2 expression and NO generation may be important in the pathogenesis of RA.

Quantification and phenotype of regulatory T cells in rheumatoid arthritis according to Disease Activity Score-28

Autoimmunity ◽  
2009 ◽  
pp. 1-1
Author(s):  
Jose Miguel Sempere-Ortells ◽  
Vicente Perez-Garcia ◽  
Gema Marin-Alberca ◽  
Alejandra Peris-Pertusa ◽  
Jose Miguel Benito ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Regulatory T Cells ◽  
Disease Activity ◽  
Disease Activity Score ◽  
Activity Score
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