scholarly journals Work status and cognitive performance in patients with relapsing remitting multiple sclerosis

2019 ◽  
Vol 36 (1) ◽  
Author(s):  
Evangelina Valeria Cores ◽  
Berenice Silva ◽  
María Bárbara Eizaguirre ◽  
Angeles Merino ◽  
Sandra Vanotti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Performance ◽  
Work Status ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

scholarly journals Work status and cognitive performance in patients with relapsing remitting multiple sclerosis

2019 ◽  
Vol 36 (1) ◽  
Author(s):  
Evangelina Valeria Cores ◽  
Berenice Silva ◽  
María Bárbara Eizaguirre ◽  
Angeles Merino ◽  
Sandra Vanotti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Performance ◽  
Work Status ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

Predicting Neuropsychological Impairment in Relapsing Remitting Multiple Sclerosis: The Role of Clinical Measures, Treatment, and Neuropsychiatry Symptoms

2020 ◽  
Author(s):  
Elena Lozano-Soto ◽  
Álvaro Javier Cruz-López ◽  
Rafael Gutiérrez ◽  
Macarena González ◽  
Florencia Sanmartino ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Depressive Symptoms ◽  
Cognitive Performance ◽  
Disease Duration ◽  
Neuropsychological Impairment ◽  
Disease Stage ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Clinical Measures ◽  
Relapsing Remitting Multiple Sclerosis

Abstract Objective This retrospective observational study aimed to define neuropsychological impairment (NI) profiles and determine the influence of clinical, demographic, and neuropsychiatric measures in specific cognitive domains in a cohort of relapsing–remitting multiple sclerosis (RRMS) patients. Methods Ninety-one RRMS patients underwent a neurological examination and a brief neuropsychological assessment. Patients were classified according to the disease-modifying therapies (DMTs) received (platform or high-efficacy). Differences between groups and multiple regression analyses were performed to determine the predictive value of the assessed measures in cognitive performance. Results More than two-thirds of the patients showed NI. Specifically, mild to moderate NI was presented in approximately half of the participants. Paced Auditory Serial Addition Test (PASAT-3) and Symbol Digit Modalities Test (SDMT) were the most frequently impaired cognitive tests (45.3% and 41.3%, respectively) followed by phonemic verbal fluency (PVF) (27.8%). Expanded Disability Status Scale (EDSS), age, depressive symptoms, and disease duration were the best predictors of SDMT (R2 = .34; p < .01), whereas disease duration, EDSS, and anxiety-state levels predicted PASAT-3 (R2 = .33, p < .01). Educational level, age, EDSS, and depressive symptoms demonstrated the strongest association with PVF (R2 = .31, p < .01). Conclusions Our results indicated a significant prevalence of NI in RRMS patients that was not dependent on the DMT type. In addition to the meaningful working memory (PASAT-3) and information processing speed (SDMT) impairments found, PVF deficits may also be an important marker of cognitive impairment in RRMS patients. This study supports the relevance of standard clinical measures and reinforces the importance of quantifying clinical and neuropsychiatric symptoms to predict subsequent cognitive performance on a similar multiple sclerosis phenotype and disease stage.

Sign in / Sign up

Export Citation Format

Share Document