Diagnostic value of Alzheimer's biomarkers in cerebrospinal fluid in dementia with Lewy body

2018 ◽  
Vol 16 (2) ◽  
pp. 174-180
Author(s):  
Olivier Bousiges ◽  
Frédéric Blanc
Keyword(s):  
Cerebrospinal Fluid ◽  
Lewy Body ◽  
Dementia With Lewy Body ◽  
Diagnostic Value

Simultaneous quantification of tau and α-synuclein in cerebrospinal fluid by high-resolution mass spectrometry for differentiation of Lewy Body Dementia from Alzheimer's Disease and controls

The Analyst ◽  
2019 ◽  
Vol 144 (21) ◽  
pp. 6342-6351 ◽  
Author(s):  
Arthur Viodé ◽  
Stéphane Epelbaum ◽  
Imen Benyounes ◽  
Marc Verny ◽  
Bruno Dubois ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cerebrospinal Fluid ◽  
High Resolution ◽  
Lewy Body ◽  
High Resolution Mass Spectrometry ◽  
Lewy Body Dementia ◽  
Diagnostic Value ◽  
Simultaneous Quantification ◽  
Resolution Mass ◽  
Mass Spectrometry Assay

A novel mass spectrometry assay offers simultaneous quantification of CSF α-synuclein and tau and has potential diagnostic value.

scholarly journals Cerebrospinal fluid from Dementia with Lewy body patients suppresses neuronal network activity

2018 ◽  
Vol 12 ◽  
Author(s):  
Stephan Theiss ◽  
Henner Koch ◽  
Walter Maetzler ◽  
Christian Deuschle ◽  
Holger Lerche ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Neuronal Network ◽  
Lewy Body ◽  
Dementia With Lewy Body ◽  
Network Activity ◽  
Neuronal Network Activity

scholarly journals Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 759
Author(s):  
Jung-Youn Han ◽  
Chaewon Shin ◽  
Young Pyo Choi
Keyword(s):  
Mouse Model ◽  
Transgenic Mice ◽  
Lewy Body ◽  
Dementia With Lewy Body ◽  
Transgenic Mouse Model ◽  
Alpha Synuclein ◽  
Gi Tract ◽  
Colon Tissue ◽  
Presymptomatic Stage ◽  
The Brain

In synucleinopathies such as Parkinson’s disease (PD) and dementia with Lewy body (DLB), pathological alpha-synuclein (α-syn) aggregates are found in the gastrointestinal (GI) tract as well as in the brain. In this study, using real-time quaking-induced conversion (RT-QuIC), we investigated the presence of α-syn seeding activity in the brain and colon tissue of G2-3 transgenic mice expressing human A53T α-syn. Here we show that pathological α-syn aggregates with seeding activity were present in the colon of G2-3 mice as early as 3 months old, which is in the presymptomatic stage prior to the observation of any neurological abnormalities. In contrast, α-syn seeding activity was not detectable in 3 month-old mouse brains and only identified at 6 months of age in one of three mice. In the symptomatic stage of 12 months of age, RT-QuIC seeding activity was consistently detectable in both the brain and colon of G2-3 mice. Our results indicate that the RT-QuIC assay can presymptomatically detect pathological α-syn aggregates in the colon of G2-3 mice several months prior to their detection in brain tissue.

Diagnostic value of cerebrospinal fluid adenosine deaminase determination

1991 ◽  
Vol 23 (1) ◽  
pp. 97-100 ◽  
Author(s):  
Tom Pettersson ◽  
Matti Klockars ◽  
Theodor H. Weber ◽  
Hannu Somer
Keyword(s):  
Cerebrospinal Fluid ◽  
Adenosine Deaminase ◽  
Diagnostic Value

scholarly journals Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Hideo Hagihara ◽  
Masayo Fujita ◽  
Juzoh Umemori ◽  
Makoto Hashimoto ◽  
Tsuyoshi Miyakawa
Keyword(s):  
Mouse Model ◽  
Lewy Body ◽  
Dementia With Lewy Body ◽  
Expression Patterns ◽  
Molecular Expression

scholarly journals Cerebrospinal Fluid Levels of sAPPαand sAPPβin Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Ezra Mulugeta ◽  
Elisabet Londos ◽  
Oskar Hansson ◽  
Clive Ballard ◽  
Ragnhild Skogseth ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Lewy Body ◽  
Group Analysis ◽  
Lewy Body Dementia ◽  
Csf Biomarkers ◽  
Commercial Kits ◽  
Neurochemical Correlates ◽  
Fluid Levels

We measured cerebrospinal fluid (CSF) levels of the soluble isoforms of amyloid precursor protein (APP; sAPPαsAPPβ) and other CSF biomarkers in 107 patients with Alzheimer's disease (AD), dementia with Lewy body dementia (DLB), Parkinson's disease dementia (PDD), and normal controls (NC) using commercial kits. DLB and PDD were combined in a Lewy body dementia group (LBD). No differences were observed in sAPPαand sAPPβlevels between the groups. Significant correlations were observed between sAPPαand sAPPβand between sAPPβand Mini-Mental State Examination scores in the total group analysis as well as when LBD and AD groups were analyzed separately. sAPPαand sAPPβlevels correlated with Aβ38, Aβ40, Aβ42, and Tau in the LBD group. In AD, sAPPαcorrelated with p-Tau and sAPPβwith Aβ40. The differential association between sAPPαand sAPPβwith Aβand Tau species between LBD and AD groups suggests a possible relationship with the underlying pathologies in LBD and AD.

[P1-386]: DISTINCT TAU ACCUMULATION PATTERN IN DEMENTIA WITH LEWY BODY

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P414-P414
Author(s):  
Seung Ha Lee ◽  
Hanna Cho ◽  
Jae Yong Choi ◽  
Young Sook Choi ◽  
Jae Hoon Lee ◽  
...  
Keyword(s):  
Lewy Body ◽  
Dementia With Lewy Body ◽  
Accumulation Pattern

O2-03-05: Beta-amyloid-17 is a major beta-amyloid fragment isoform in cerebrospinal fluid and blood that shows diagnostic value

2012 ◽  
Vol 8 (4S_Part_7) ◽  
pp. P240-P240 ◽  
Author(s):  
Virginia Pérez ◽  
Leticia Sarasa ◽  
Jose A. Allue ◽  
Diego Casabona ◽  
Maria Montanes ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Beta Amyloid ◽  
Diagnostic Value
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