Cervical cancer in sub-Saharan Africa: an emerging and preventable disease associated with oncogenic human papillomavirus

2017 ◽  
Vol 27 (1) ◽  
pp. 16-22 ◽  
Author(s):  
R.S. Mboumba Bouassa ◽  
T. Prazuck ◽  
T. Lethu ◽  
J.F. Meye ◽  
L. Bélec
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Sub Saharan Africa ◽  
Preventable Disease ◽  
Sub Saharan

scholarly journals Stakeholders’ Understandings of Human Papillomavirus (HPV) Vaccination in Sub-Saharan Africa: A Rapid Qualitative Systematic Review

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 496
Author(s):  
Caroline Deignan ◽  
Alison Swartz ◽  
Sara Cooper ◽  
Christopher J. Colvin
Keyword(s):  
Systematic Review ◽  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Hpv Vaccine ◽  
Hpv Vaccination ◽  
Sub Saharan Africa ◽  
African Countries ◽  
Qualitative Systematic Review ◽  
Sub Saharan ◽  
And Gender

Cervical cancer rates in Sub-Saharan Africa (SSA) are amongst the highest worldwide. All three of the Human Papillomavirus (HPV) vaccines (9-valent, quadrivalent and bivalent HPV vaccine) provide primary protection against the most common cancer-causing strains of HPV (types 16 and 18) that are known to cause 70% of cervical cancers. Over the last five years, there has been an increase in Sub-Saharan African countries that have introduced the HPV vaccine. The majority of research has been conducted on supply-side barriers and facilitators to HPV vaccination uptake in SSA, yet little research has been conducted on demand-side or end-user perspectives of, and decisions around, HPV vaccination. In order to complement existing research, and inform current and future HPV vaccination implementation approaches, this qualitative systematic review explored Stakeholders’ understandings of HPV vaccination in SSA. This review searched the following databases: Embase (via Scopus), Scopus, MEDLINE (via PubMed), PubMed, EBSCOhost, Academic Search Premier, Africa-Wide Information, CINAHL, PsycARTICLES, PsycINFO, SocINDEX, Web of Science, and the Cochrane Controlled Register of Trials (CENTRAL) and found a total of 259 articles. Thirty-one studies were found eligible for inclusion and were analyzed thematically using Braun and Clarke’s methods for conducting a thematic analysis. The quality of included studies was assessed using the Critical Appraisal Skills Programme (CASP) checklist. Three major themes emerged from this analysis; knowledge of HPV vaccination and cervical cancer is intertwined with misinformation; fear has shaped contradictory perceptions about HPV vaccination and gender dynamics are relevant in how stakeholders understand HPV vaccination in SSA.

scholarly journals Human papillomavirus prevalence and type distribution in invasive cervical cancer in sub-Saharan Africa

2013 ◽  
Vol 134 (6) ◽  
pp. 1389-1398 ◽  
Author(s):  
Lynette Denny ◽  
Isaac Adewole ◽  
Rose Anorlu ◽  
Greta Dreyer ◽  
Manivasan Moodley ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Invasive Cervical Cancer ◽  
Sub Saharan Africa ◽  
Type Distribution ◽  
Sub Saharan

scholarly journals Awareness and Knowledge of Human Papillomavirus and Cervical Cancer Among Female Medical and Health Science Students at University of Gondar

2017 ◽  
Vol 3 (2_suppl) ◽  
pp. 36s-36s ◽  
Author(s):  
Zelalem Tilahun Tesfaye ◽  
Eyob Alemayehu Gebreyohannes ◽  
Akshaya Srikanth Bhagavathula ◽  
Melaknesh Minda Getaneh ◽  
Henok Getachew Tegegn
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
University Students ◽  
Young Women ◽  
Health Sciences ◽  
Female Students ◽  
Health Science ◽  
Sub Saharan Africa ◽  
Students At Risk ◽  
Sub Saharan

Abstract 6 Background: Cervical cancer is causing a burden in sub-Saharan Africa, with human papillomavirus (HPV) identified as the necessary cause of cervical cancer. HPV mainly affects young women, which puts female university students at risk of cervical cancer. Knowledge and awareness of cervical cancer and HPV in sub-Saharan Africa, including Ethiopia, is poor. The aim of this study was to assess the knowledge and awareness of cervical cancer and HPV in University of Gondar medicine and health science female students. Methods: This cross-sectional study was conducted from April 1 to May 30, 2016, at University of Gondar, College of Medicine and Health Sciences, Gondar, Ethiopia. Undergraduate female students from 11 different health-related departments at the College of Medicine and Health Sciences were included in the study. A 14-item, paper-based, self-administered questionnaire was provided to each of the participants to measure her level of knowledge and awareness of cervical cancer and HPV. Results: A total of 267 female students participated in the study, with ages ranging from 18 to 24 years (mean age, 20.58 ± 1.22 years). More than one half of participants (59.6%) stated that they did not know the main cause of cervical cancer, whereas only approximately one fifth (19.5%) identified HPV as the main cause of cervical cancer. As many as 83.9% of participants did not know other causes of cervical cancer. Binary logistic analysis revealed that students from midwifery (adjusted odds ratio [AOR], 14.14; P < .05), anesthesiology (AOR, 9.66; P < .05), and medicine (AOR, 5.84; P < .05) departments were associated with knowledge of the main cause of cervical cancer. Furthermore, fifth-year students (AOR, 16.94; P < .05) and fourth-year students (AOR, 8.32; P < .05) were found to have better knowledge of the main cause of cervical cancer. Only a few students (15%) had been vaccinated for HPV or had had a cervical smear test performed in the past. Conclusion: Cervical cancer mainly affects young women, which puts female university students at risk of cervical cancer. Hence, assessing the knowledge and awareness of these students will be of paramount importance to designing effective measures to increase their knowledge and awareness of the disease. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST No COIs from the authors.

scholarly journals Cervix Cancer in Sub-Saharan Africa: An Assessment of Cervical Cancer Management

2021 ◽  
pp. 173-182
Author(s):  
Lindsay M. Burt ◽  
Mary McCormak ◽  
Fabrice Lecuru ◽  
Daniel M. Kanyike ◽  
Memory Bvochora-Nsingo ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Research ◽  
Clinical Trials ◽  
Human Papillomavirus ◽  
Screening Program ◽  
Sub Saharan Africa ◽  
Human Papillomavirus Vaccination ◽  
Adequate Treatment ◽  
Cancer Management ◽  
Sub Saharan

PURPOSE Underdeveloped nations carry the burden of most cervical cancer, yet access to adequate treatment can be challenging. This report assesses the current management of cervical cancer in sub-Saharan Africa to better understand the needs of underdeveloped nations in managing cervical cancer. METHODS A pre- and postsurvey was sent to all centers participating in the Cervical Cancer Research Network's 4th annual symposium. The pre- and postsurvey evaluated human papillomavirus and HIV screening, resources available for workup and/or treatment, treatment logistics, outcomes, and enrollment on clinical trials. Descriptive analyses were performed on survey responses. RESULTS Twenty-nine centers from 12 sub-Saharan countries saw approximately 300 new cases of cervical cancer yearly. Of the countries surveyed, 55% of countries had a human papillomavirus vaccination program and 30% (range, 0%-65%) of women in each region were estimated to have participated in a cervical cancer screening program. In the workup of patients, 43% of centers had the ability to obtain a positron emission tomography and computed tomography scan and 79% had magnetic resonance imaging capabilities. When performing surgery, 88% of those centers had a surgeon with an expertise in performing oncological surgeries. Radiation therapy was available at 96% of the centers surveyed, and chemotherapy was available in 86% of centers. Clinical trials were open at 4% of centers. CONCLUSION There have been significant advancements being made in screening, workup, and management of patients with cervical cancer in sub-Saharan Africa; yet, improvement is still needed. Enrollment in clinical trials remains a struggle. Participants would like to enroll patients on clinical trials with Cervical Cancer Research Network's continuous support.

Trials and Projects on Cervical Cancer and Human Papillomavirus Prevention in Sub-Saharan Africa

Vaccine ◽  
2013 ◽  
Vol 31 ◽  
pp. F53-F59 ◽  
Author(s):  
Peter O. Adefuye ◽  
Nathalie J. Broutet ◽  
Silvia de Sanjosé ◽  
Lynette A. Denny
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Sub Saharan Africa ◽  
Sub Saharan

Systematic review of cervical cancer prevalence and determinants of early detection in Sub-Saharan Africa

2018 ◽  
Vol 1 (1) ◽  
pp. 32-36
Author(s):  
Eleazar Ndabarora ◽  
Dariya Mukamusoni ◽  
Clarte Ndikumasabo ◽  
Védaste Ngirinshuti
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Early Detection ◽  
Cervical Cancer Screening ◽  
Sub Saharan Africa ◽  
Extensive Literature ◽  
Early Management ◽  
Screening Programs ◽  
Mesh Terms ◽  
Sub Saharan

Cervical cancer is one of the leading causes of morbidity and mortality globally and in Sub-Saharan Africa in particular. There is evidence that early detection and early management of cases are the best strategies to prevent and control this health threat, since treatment of the later stages of the diseases are very expensive. The objectives of the review were: (1) to identify and review studies on the prevalence of cervical cancer and determinants of early detection in Sub-Saharan Africa, and (2) to recommend further studies and interventions based on the findings of this review. Extensive literature search was conducted using the MeSH terms. Articles on cervical cancer and/or determinants of early detection which fulfilled inclusion criteria were reviewed independently by three reviewers. The prevalence of cervical cancer in Sub-Saharan Africa is increasing. Although there are evidences that cervical cancer screening programs are practical and feasible even in resource-limited settings in Sub-Saharan Africa, there is a very low uptake of cervical cancer screening and there are key factors that need to be addressed in order to make these programs established and effective.

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