A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats

2018 ◽  
Vol 31 (1) ◽  
pp. 24-32 ◽  
Author(s):  
Vedrana Đurić ◽  
Bojan Batinić ◽  
Jelena Petrović ◽  
Dušanka Stanić ◽  
Zorica Bulat ◽  
...  
Keyword(s):  
Single Dose ◽  
Object Recognition ◽  
Chronic Administration ◽  
Long Term Memory ◽  
Novel Object Recognition ◽  
Object Recognition Test ◽  
Term Memory ◽  
Novel Object ◽  
Novel Object Recognition Test

scholarly journals Conversion of short-term to long-term memory in the novel object recognition paradigm

2013 ◽  
Vol 105 ◽  
pp. 174-185 ◽  
Author(s):  
Shannon J. Moore ◽  
Kaivalya Deshpande ◽  
Gwen S. Stinnett ◽  
Audrey F. Seasholtz ◽  
Geoffrey G. Murphy
Keyword(s):  
Object Recognition ◽  
Long Term Memory ◽  
Novel Object Recognition ◽  
The Novel ◽  
Short Term ◽  
Term Memory ◽  
Novel Object

scholarly journals Perineuronal Net Receptor PTPσ Regulates Retention of Memories

2021 ◽  
Vol 13 ◽  
Author(s):  
Angelina Lesnikova ◽  
Plinio Casarotto ◽  
Rafael Moliner ◽  
Senem Merve Fred ◽  
Caroline Biojone ◽  
...  
Keyword(s):  
Object Recognition ◽  
Fear Conditioning ◽  
Cognitive Flexibility ◽  
Long Term Memory ◽  
Novel Object Recognition ◽  
Short Term ◽  
Perineuronal Net ◽  
Term Memory ◽  
Novel Object

Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods of intensive learning, usually in late childhood, and they help in long-term preservation of newly acquired skills and information. Modulation of PNN function by various techniques enhances plasticity and regulates the retention of memories, which may be beneficial when memory persistence entails negative symptoms such as post-traumatic stress disorder (PTSD). In this study, we investigated the role of PTPσ [receptor-type tyrosine-protein phosphatase S, a phosphatase that is activated by binding of chondroitin sulfate proteoglycans (CSPGs) from PNNs] in retention of memories using Novel Object Recognition and Fear Conditioning models. We observed that mice haploinsufficient for PTPRS gene (PTPσ+/–), although having improved short-term object recognition memory, display impaired long-term memory in both Novel Object Recognition and Fear Conditioning paradigm, as compared to WT littermates. However, PTPσ+/– mice did not show any differences in behavioral tests that do not heavily rely on cognitive flexibility, such as Elevated Plus Maze, Open Field, Marble Burying, and Forced Swimming Test. Since PTPσ has been shown to interact with and dephosphorylate TRKB, we investigated activation of this receptor and its downstream pathways in limbic areas known to be associated with memory. We found that phosphorylation of TRKB and PLCγ are increased in the hippocampus, prefrontal cortex, and amygdaloid complex of PTPσ+/– mice, but other TRKB-mediated signaling pathways are not affected. Our data suggest that PTPσ downregulation promotes TRKB phosphorylation in different brain areas, improves short-term memory performance but disrupts long-term memory retention in the tested animal models. Inhibition of PTPσ or disruption of PNN-PTPσ-TRKB complex might be a potential target for disorders where negative modulation of the acquired memories can be beneficial.

scholarly journals NAAG peptidase inhibitors and deletion of NAAG peptidase gene enhance memory in novel object recognition test

2013 ◽  
Vol 701 (1-3) ◽  
pp. 27-32 ◽  
Author(s):  
Karolina J. Janczura ◽  
Rafal T. Olszewski ◽  
Tomasz Bzdega ◽  
Dean J. Bacich ◽  
Warren D. Heston ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Test ◽  
Novel Object Recognition ◽  
Object Recognition Test ◽  
Novel Object ◽  
Peptidase Inhibitors ◽  
Novel Object Recognition Test ◽  
Naag Peptidase
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