scholarly journals Sleep-related hypermotor epilepsy and peri-ictal hypotension in a patient with syntaxin-1B mutation

2018 ◽  
Vol 20 (5) ◽  
pp. 413-417 ◽  
Author(s):  
Joao Peres ◽  
Francisco Antunes ◽  
Bilal Zonjy ◽  
Anna L. Mitchell ◽  
Samden D. Lhatoo
Keyword(s):  
Syntaxin 1B

scholarly journals VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Alberto Lleó ◽  
Maria Carmona-Iragui ◽  
Laura Videla ◽  
Susana Fernández ◽  
Bessy Benejam ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Down Syndrome ◽  
Cognitive Impairment ◽  
Episodic Memory ◽  
Cognitive Performance ◽  
Synaptic Proteins ◽  
Selected Reaction Monitoring ◽  
Synaptic Protein ◽  
Csf Levels ◽  
Syntaxin 1B

Abstract Background There is an urgent need for objective markers of Alzheimer’s disease (AD)-related cognitive impairment in people with Down syndrome (DS) to improve diagnosis, monitor disease progression, and assess response to disease-modifying therapies. Previously, GluA4 and neuronal pentraxin 2 (NPTX2) showed limited potential as cerebrospinal fluid (CSF) markers of cognitive impairment in adults with DS. Here, we compare the CSF profile of a panel of synaptic proteins (Calsyntenin-1, Neuroligin-2, Neurexin-2A, Neurexin-3A, Syntaxin-1B, Thy-1, VAMP-2) to that of NPTX2 and GluA4 in a large cohort of subjects with DS across the preclinical and clinical AD continuum and explore their correlation with cognitive impairment. Methods We quantified the synaptic panel proteins by selected reaction monitoring in CSF from 20 non-trisomic cognitively normal controls (mean age 44) and 80 adults with DS grouped according to clinical AD diagnosis (asymptomatic, prodromal AD or AD dementia). We used regression analyses to determine CSF changes across the AD continuum and explored correlations with age, global cognitive performance (CAMCOG), episodic memory (modified cued-recall test; mCRT) and CSF biomarkers, CSF Aβ42:40 ratio, CSF Aβ1-42, CSF p-tau, and CSF NFL. P values were adjusted for multiple testing. Results In adults with DS, VAMP-2 was the only synaptic protein to correlate with episodic memory (delayed recall adj.p = .04) and age (adj.p = .0008) and was the best correlate of CSF Aβ42:40 (adj.p = .0001), p-tau (adj.p < .0001), and NFL (adj.p < .0001). Compared to controls, mean VAMP-2 levels were lower in asymptomatic adults with DS only (adj.p = .02). CSF levels of Neurexin-3A, Thy-1, Neurexin-2A, Calysntenin-1, Neuroligin-2, GluA4, and Syntaxin-1B all strongly correlated with NPTX2 (p < .0001), which was the only synaptic protein to show reduced CSF levels in DS at all AD stages compared to controls (adj.p < .002). Conclusion These data show proof-of-concept for CSF VAMP-2 as a potential marker of synapse degeneration that correlates with CSF AD and axonal degeneration markers and cognitive performance.

scholarly journals Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B

2011 ◽  
Vol 61 (3) ◽  
Author(s):  
Sayaka Tanaka ◽  
Hiroyuki Kabayama ◽  
Masahiro Enomoto ◽  
Nobuhito Saito ◽  
Katsuhiko Mikoshiba
Keyword(s):  
Inositol 1 ◽  
Syntaxin 1B ◽  
Trisphosphate Receptor

scholarly journals Changes in syntaxin-1B mRNA in the nucleus accumbens of amphetamine-sensitized rats

2005 ◽  
Vol 9 (06) ◽  
pp. 751 ◽  
Author(s):  
Sanjeev K. Bhardwaj ◽  
Clifford M. Cassidy ◽  
Lalit K. Srivastava
Keyword(s):  
Nucleus Accumbens ◽  
Syntaxin 1B

Assignment of the Human Syntaxin 1B Gene (STX) to Chromosome 16p11.2 by Fluorescencein SituHybridization

Genomics ◽  
1996 ◽  
Vol 36 (3) ◽  
pp. 551-553 ◽  
Author(s):  
Tania Smirnova ◽  
Pierre Miniou ◽  
Evani Viegas-Pequignot ◽  
Jacques Mallet
Keyword(s):  
Syntaxin 1B

scholarly journals HPC-1/syntaxin 1A and syntaxin 1B play distinct roles in neuronal survival

2014 ◽  
Vol 130 (4) ◽  
pp. 514-525 ◽  
Author(s):  
Takefumi Kofuji ◽  
Tomonori Fujiwara ◽  
Masumi Sanada ◽  
Tatsuya Mishima ◽  
Kimio Akagawa
Keyword(s):  
Neuronal Survival ◽  
Syntaxin 1A ◽  
Syntaxin 1B

scholarly journals Syntaxin 1B, but Not Syntaxin 1A, Is Necessary for the Regulation of Synaptic Vesicle Exocytosis and of the Readily Releasable Pool at Central Synapses

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e90004 ◽  
Author(s):  
Tatsuya Mishima ◽  
Tomonori Fujiwara ◽  
Masumi Sanada ◽  
Takefumi Kofuji ◽  
Masami Kanai-Azuma ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Syntaxin 1A ◽  
Releasable Pool ◽  
Readily Releasable Pool ◽  
Synaptic Vesicle Exocytosis ◽  
Vesicle Exocytosis ◽  
Syntaxin 1B ◽  
Central Synapses

Syntaxin 1B-reduction-triggered macropinocytosis mediates Sema3A-induced growth cone collapse

2011 ◽  
Vol 71 ◽  
pp. e95
Author(s):  
Hiroyuki Kabayama ◽  
Makoto Takeuchi ◽  
Masahiko Taniguchi ◽  
Naoko Tokushige ◽  
Shunji Kozaki ◽  
...  
Keyword(s):  
Growth Cone ◽  
Growth Cone Collapse ◽  
Syntaxin 1B

scholarly journals Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS

2017 ◽  
Vol 46 (12) ◽  
pp. 2867-2874 ◽  
Author(s):  
Tomonori Fujiwara ◽  
Takefumi Kofuji ◽  
Tatsuya Mishima ◽  
Kimio Akagawa
Keyword(s):  
Dopaminergic System ◽  
Syntaxin 1B ◽  
Gaba Transmission
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