Drug treatment strategies for epilepsy revisited: starting early or late? One drug or several drugs?

2016 ◽  
Vol 18 (4) ◽  
pp. 356-366 ◽  
Author(s):  
Dieter Schmidt
Keyword(s):  
Drug Treatment ◽  
Treatment Strategies

Synergistic Apoptotic Effect of Naringenin on enhancing the Anti-Glioma Efficacy of Temozolomide in an in vitro Experimental Model

2021 ◽  
Vol 16 (10) ◽  
pp. 43-49
Author(s):  
Precilla S. Daisy ◽  
S. Kuduvalli Shreyas ◽  
R. Sathish ◽  
T.S. Anitha
Keyword(s):  
Drug Treatment ◽  
Caspase 3 ◽  
Treatment Strategies ◽  
Glioma Cells ◽  
C6 Glioma ◽  
Mitigation Strategies ◽  
Treatment Modalities ◽  
C6 Glioma Cells ◽  
Dependent Manner

Glioma is one of the most devastating and difficult-totreat brain tumors with a very poor prognosis. Despite the current treatment modalities, the overall survival rate is only 5% contributing to a high mortality rate. Nevertheless, of emerging treatment strategies, there is still a rising need for novel mitigation strategies to counteract glioma aggressiveness. One attempt towards this long-term goal was made in this study to reveal the combined efficacy of naringenin, a bioactive flavonoid on enhancing the anti-glioma potency of temozolomide in C6 glioma cells. The cytotoxic effect of temozolomide and naringenin, both individually and in combination was assessed by employing MTT assay. The synergistic effect of the drugs temozolomide and naringenin was determined by calculating the combination index. To confirm the presence of apoptotic changes in the cells at morphological level, acridine orange/ethidium bromide staining was performed. Further, the modulatory effects of the drugs on apoptotic genes, caspase-3 and BCL-2 were evaluated using quantitative real time-PCR. Interestingly, we found that the combinatorial drug treatment was in consensus and effectively inhibited the growth of C6 glioma cells in a dose-dependent manner. Furthermore, this combinatorial drug treatment significantly up-regulated the expression of the proapoptotic gene, caspase-3 and down-regulated the anti-apoptotic gene BCL-2 suggesting a shift of equilibrium towards apoptosis. Our findings suggest that naringenin can be employed as a potent drug to enhance the anti-glioma efficacy of temozolomide and could be therapeutically exploited for the management of glioma.

Drug treatment strategies for depression in Parkinson disease

2019 ◽  
Vol 20 (11) ◽  
pp. 1351-1363 ◽  
Author(s):  
Melody Ryan ◽  
Courtney V. Eatmon ◽  
John T. Slevin
Keyword(s):  
Drug Treatment ◽  
Parkinson Disease ◽  
Treatment Strategies

scholarly journals Comparative effectiveness of long term drug treatment strategies to prevent asthma exacerbations: network meta-analysis

BMJ ◽  
2014 ◽  
Vol 348 (may13 3) ◽  
pp. g3009-g3009 ◽  
Author(s):  
R. J. B. Loymans ◽  
A. Gemperli ◽  
J. Cohen ◽  
S. M. Rubinstein ◽  
P. J. Sterk ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Comparative Effectiveness ◽  
Meta Analysis ◽  
Treatment Strategies ◽  
Asthma Exacerbations

Augmentation and combination of antidepressants with each other and with antipsychotics

2011 ◽  
Vol 26 (S2) ◽  
pp. 698-698
Author(s):  
L. Timmerman
Keyword(s):  
Drug Treatment ◽  
Remission Rate ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Augmentation Therapy ◽  
First Line ◽  
Severe Problem ◽  
Medline Search ◽  
New Treatment ◽  
Line Drug

IntroductionNonrespons in first -line drug treatment of patients suffering from depression in psychiatric outpatient populations is a severe problem.The non respons rate is up tot 30% and the non remission rate more than 50% in the first line of treatment with antidepressants in this population.ObjectiveTo devellop more rapid and efficious drug treatment strategies in depression.AimsDuring the last few years several strategies to improve outcome in depression have been under investigation. A few have proven to be valuable.MethodsMedline search 2005–2010 into treatment resistent depression, combination therapy, augmentation therapy, drug therapy.ResultThere is growing evidence for the value of the combination of antidepressants and of combining antidepressants with antipsychotics.Treatment options as pindolol addition to antidepressants, substance P or folic acid addition do not seem of clinical significance yet.The same is true for treatment methods who directly influence the glucocorticoid system such as glucocorticoid receptor antagonists.NMDA antagonists look promising but more research into this option is needed.ConclusionsThere are two outstanding and much promising relatively new treatment options with: Combinations of antidepressants and with combinations of an antidepressant with an antipsychotic.

scholarly journals An Overview of Investigational and Experimental Drug Treatment Strategies for Marfan Syndrome

2021 ◽  
Vol Volume 13 ◽  
pp. 755-779
Author(s):  
Violette Deleeuw ◽  
Adelbert De Clercq ◽  
Julie De Backer ◽  
Patrick Sips
Keyword(s):  
Drug Treatment ◽  
Marfan Syndrome ◽  
Treatment Strategies ◽  
Experimental Drug

Vocally disruptive behavior: A case report and literature review

2019 ◽  
pp. 1-6
Author(s):  
Barry McCarthy ◽  
Anna Boland ◽  
Sinead Murphy ◽  
Colm Cooney
Keyword(s):  
Drug Treatment ◽  
Disruptive Behavior ◽  
Challenging Behavior ◽  
Psychological Symptoms ◽  
Treatment Strategies ◽  
Pharmacological Profile ◽  
Current Management ◽  
Management Guidelines ◽  
Factors Associated ◽  
Behavioral And Psychological Symptoms

Vocally disruptive behavior (VDB) is a common and particularly difficult symptom to manage in dementia. VDB is usually considered collectively with agitation and aggression as a component of behavioral and psychological symptoms in dementia and is therefore poorly understood as an individual symptom. A review of the literature is described where VDB as a challenging behavior has been individually examined as a symptom. A case of VDB occurring in patient with dementia is described where the patient’s repetitive vocalizations responded to treatment with pregabalin. This has not been previously reported in the literature. The prevalence of VDB, the factors associated with it and the current management guidelines for clinicians are outlined with a review of the drug treatment strategies for VDB. Pregabalin with its unique pharmacological profile and excellent tolerability should be considered as a possible treatment for VDB where drug treatment is indicated.

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