Basal cell carcinoma in a patient with Wiskott-Aldrich syndrome: an immunohistochemical analysis of infiltrating cells around the tumour

2020 ◽  
Vol 30 (4) ◽  
pp. 421-422
Author(s):  
Hind Al-Busani ◽  
Takeshi Namiki ◽  
Yusuke Yoshioka ◽  
Tsukasa Ugajin ◽  
Keiko Miura ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Immunohistochemical Analysis ◽  
Wiskott Aldrich Syndrome ◽  
Infiltrating Cells

scholarly journals Prostate Basal Cell Carcinoma: A Case Report

2018 ◽  
Vol 11 (1) ◽  
pp. 138-142 ◽  
Author(s):  
Sahoko Ninomiya ◽  
Takashi Kawahara ◽  
Hiromichi Iwashita ◽  
Genta Iwamoto ◽  
Daiji Takamoto ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Immunohistochemical Analysis ◽  
Pathological Examination ◽  
Ki 67 ◽  
Prostate Hyperplasia ◽  
Atypical Cells ◽  
Prostate Cancers ◽  
Benign Prostate

Prostate basal cell carcinoma (PBCC) accounts for 0.01% of all prostate cancers. A 68-year-old man complained of dysuria for 5 years on his initial visit. His PSA level was 3.87 ng/mL. Due to a diagnosis of benign prostate hyperplasia, he underwent transurethral resection of the prostate. A pathological examination revealed that basal cell-like atypical cells made alveolar with palisadal layout. Immunohistochemical analysis showed positive 34β12, P63, and Ki-67. Based on these findings, PBCC was diagnosed. Then, we performed radical prostatectomy. He was free from recurrence 22 months after the operation. We herein report an extremely rare case of PBCC.

Regression in basal cell carcinoma: an immunohistochemical analysis

1994 ◽  
Vol 130 (1) ◽  
pp. 1-8 ◽  
Author(s):  
M.J. HUNT ◽  
G.M. HALLIDAY ◽  
D. WEEDON ◽  
B.E. COOKE ◽  
R. StC. BARNETSON
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Immunohistochemical Analysis

Immunohistochemical analysis of laminin 5-γ2 chain expression for differentiation of basal cell carcinoma from trichoblastoma

2011 ◽  
Vol 59 (1) ◽  
pp. 159-161 ◽  
Author(s):  
Haruka Hamasaki ◽  
Kaori Koga ◽  
Makoto Hamasaki ◽  
Hiromaro Kiryu ◽  
Juichiro Nakayama ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Immunohistochemical Analysis ◽  
Laminin 5

scholarly journals Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e106427 ◽  
Author(s):  
Tjinta Brinkhuizen ◽  
Chantal A. H. Weijzen ◽  
Jonathan Eben ◽  
Monique R. Thissen ◽  
Ariënne M. van Marion ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Immunohistochemical Analysis ◽  
Target Of Rapamycin ◽  
Signalling Pathways ◽  
Mechanistic Target Of Rapamycin

Immunohistochemical analysis of TIMP-3 and MMP-9 in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma

2013 ◽  
Vol 209 (11) ◽  
pp. 705-709 ◽  
Author(s):  
Fabiano O. Poswar ◽  
Carlos A.C. Fraga ◽  
Lucyana C. Farias ◽  
John D. Feltenberger ◽  
Vitória P.D. Cruz ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Actinic Keratosis ◽  
Immunohistochemical Analysis

Carcinoma of the Mammary Crease Simulating Rodent Ulcer Basal Cell Carcinoma. Report of a Case with Immunohistochemical Analysis

1997 ◽  
Vol 23 (6) ◽  
pp. 494-495
Author(s):  
F. VAZQUEZ-LÓPEZ ◽  
MANUEL F. FRESNO ◽  
I. FIDALGO ◽  
J. M. ARRIBAS ◽  
N. PÉREZ-OLJVA
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Immunohistochemical Analysis

scholarly journals Expression of Endothelins and Their Receptors in Nonmelanoma Skin Cancers

2006 ◽  
Vol 10 (6) ◽  
pp. 269-276 ◽  
Author(s):  
Yi Zhang ◽  
Liren Tang ◽  
Mingwan Su ◽  
Daniel Eisen ◽  
David Zloty ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Survival ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Basal Cell ◽  
Quantitative Polymerase Chain Reaction ◽  
Immunohistochemical Analysis ◽  
Seborrheic Keratosis ◽  
Growth And Survival ◽  
Cultured Keratinocytes

Background: Endothelins are paracrine peptides with growth-promoting and vasoactive functions for a variety of cell types. Elevated activation of the endothelin signaling pathway induces cell proliferation and/or survival and is implicated in a variety of malignancies. Increased endothelin 1 was described in solar lentigines in previous reports, raising the possibility that the endothelin pathway may be of significance in keratinocyte proliferation-related disorders. However, detailed investigation on endothelins in skin malignancies is lacking. Objectives: This study aims to survey the expression of endothelins and their receptors in keratinocyte-derived benign and malignant tumors of the skin and to test the effects of endothelin inhibitors on the growth and survival of cultured keratinocytes. Methods: Quantitative polymerase chain reaction was used to measure the level of gene transcription of three endothelins (ET-1, −2, and −3) and two endothelin receptors (ETRA and ETRB). The genes with significant messenger ribonucleic acid (mRNA) expression abnormalities were confirmed with immunohistochemical analysis to examine expression differences at the protein levels. To analyze the effect of endothelin inhibitors on the keratinocyte growth and survival, keratinocytes were cultured in the presence of various concentrations of endothelin inhibitors and subjected to tetrazolium bromide assay to quantify the cell numbers over time. Results: ET-1 mRNA was found to be significantly up-regulated in seborrheic keratosis and basal cell carcinoma. However, no significant expression increase was found in actinic keratosis, Bowen's disease, or squamous cell carcinoma. Immunohistochemical analysis of ET-1 peptide confirmed increased expression. In cultured keratinocytes, peptide inhibitors of the endothelin pathway resulted in a marked reduction in cell survival. Conclusion: The endothelin signaling pathway, especially ET-1, is activated in basoloid keratinocyte neoplasms of the skin, such as basal cell carcinoma and seborrheic keratosis. Blockade of this pathway can reduce cell survival in vitro. Therefore, endothelin inhibitors potentially offer a novel method for the treatment of some keratinocyte-derived skin tumors.

Ultrastructure of Mouse Basal Cell Carcinoma Exhibiting Sebaceous Differentiation

1980 ◽  
Vol 38 ◽  
pp. 738-739
Author(s):  
Victoria L. Wade ◽  
Winslow G. Sheldon ◽  
James W. Townsend ◽  
William Allaben
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Topical Application ◽  
Basal Cell ◽  
Sebaceous Gland ◽  
Rats And Mice ◽  
Mixed Tumors

Sebaceous gland tumors and other tumors exhibiting sebaceous differentiation have been described in humans (1,2,3). Tumors of the sebaceous gland can be induced in rats and mice following topical application of carcinogens (4), but spontaneous mixed tumors of basal cell origin rarely occur in mice.

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