Dermoscopy of congenital melanocytic nevi: a ten-year follow-up study and comparative analysis with acquired melanocytic nevi arising in prepubertal age

2017 ◽  
Vol 27 (5) ◽  
pp. 505-510 ◽  
Author(s):  
Enzo Errichetti ◽  
Martina Maria Patriarca ◽  
Giuseppe Stinco
Keyword(s):  
Comparative Analysis ◽  
Melanocytic Nevi ◽  
Follow Up Study ◽  
Congenital Melanocytic Nevi ◽  
Prepubertal Age

Risk of melanoma in medium-sized congenital melanocytic nevi: A follow-up study

1998 ◽  
Vol 39 (3) ◽  
pp. 428-433 ◽  
Author(s):  
Sedef Sahin ◽  
Ludmila Levin ◽  
Alfred W. Kopf ◽  
Babar K. Rao ◽  
Marc Triola ◽  
...  
Keyword(s):  
Melanocytic Nevi ◽  
Follow Up Study ◽  
Congenital Melanocytic Nevi

scholarly journals Comparative Analysis Between Fly Ash Geopolymer and Reactive Ultra-Fine Fly Ash Geopolymer

2021 ◽  
Vol 11 (3) ◽  
pp. 161-170
Author(s):  
Wei-Ting Lin ◽  
Kae-Long Lin ◽  
Kinga Korniejenko ◽  
Lukáš Fiala
Keyword(s):  
Compressive Strength ◽  
Comparative Analysis ◽  
Fly Ash ◽  
Sodium Hydroxide ◽  
Hydration Products ◽  
High Compressive Strength ◽  
Alkali Activator ◽  
Follow Up Study ◽  
Alumino Silicate

This study investigates novel geopolymers by combining Reactive Ultra-fine Fly Ash (RUFA) with 4M sodium hydroxide as an alkali activator. Comparing with general fly ash geopolymers, RUFA geopolymer pastes are characterized in terms of compressive strength, microstructure, and crystalline phases. The RUFA geopolymer is successfully obtained as alumina-silicate bonding materials with the same properties as the general fly ash-based geopolymer. The high compressive strength of the RUFA-based geopolymer samples (13.33 MPa) can be attributed primarily to Ca-based alumino-silicate hydration products and Na-based alumino-silicate complexes. This research  presents an innovative application for geopolymers using RUFA. In the follow-up study, the influence of synthesis and concentration of alkali activator can be considered in RUFA-based geopolymers.

Aanpak en behandelingsopties voor congenitale melanocytaire naevi

2021 ◽  
Author(s):  
A. VANNESTE ◽  
M. GARMYN ◽  
M.-A. MORREN
Keyword(s):  
Treatment Options ◽  
Neurological Complications ◽  
Treatment Modalities ◽  
Melanocytic Nevi ◽  
The Central Nervous System ◽  
Magnetic Resonance Imaging Mri ◽  
Long Term Prognosis ◽  
Congenital Melanocytic Nevi

Management and treatment options in congenital melanocytic nevi Congenital melanocytic nevi (CMN) are benign collections of nevus cells in the skin. They are present at birth or arise during the first weeks of life. Depending on the size, they appear in 1 in 100 to 500.000 live births. CMN are associated with a variety of benign conditions such as benign proliferations, certain facial characteristics or subtle endocrine dysfunctions as well as malign developments such as melanoma and neurological complications. The risk for these complications strongly depends on the clinical phenotype. Magnetic resonance imaging (MRI) has a strong value in estimating the risk of these complications. A normal MRI of the central nervous system results in a lower risk of developing melanoma and neurological complications because of the thorough follow-up and early capture. Although there are various treatment modalities, a shift to more conservative treatment is seen. Little is known about the long term prognosis after treatment of CMN. This article tries to give a recommendation for treatment and follow-up of CMN based on the current literature.

scholarly journals Effect of prematurity on fat mass distribution and blood pressure at prepubertal age: a follow-up study

2013 ◽  
Vol 35 (4) ◽  
Author(s):  
P. Piemontese ◽  
N. Liotto ◽  
F. Garbarino ◽  
D. Morniroli ◽  
F. Taroni ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mass Distribution ◽  
Fat Mass ◽  
Follow Up Study ◽  
Prepubertal Age

scholarly journals Ultra-pulsed Carbon Dioxide Laser for the Treatment of Melanocytic Nevi

2019 ◽  
Vol 4 (2) ◽  
pp. 01-04
Author(s):  
Ali Mohamed Gargoom ◽  
Gamal Ahmed Duweb
Keyword(s):  
Co2 Laser ◽  
Carbon Dioxide Laser ◽  
Adverse Side Effect ◽  
Melanocytic Nevi ◽  
Final Treatment ◽  
Atrophic Scar ◽  
Pulsed Co2 Laser ◽  
Cosmetic Outcomes ◽  
Congenital Melanocytic Nevi

Abstract: Congenital melanocytic nevi (CMN) even small-sized as well as acquired melanocytic nevi (AMN) are of common cosmetic concerns and getting rid of them remain challenging. The aim of this study is to evaluate the efficacy and safety of the ultra-pulsed CO2 laser for the treatment of melanocytic nevi. 15 male and female Libyan patients with 16 AMN and 7 CMN were treated with multiple sessions of ultra-pulsed CO2 laser at 1-month intervals. Clinical response at 6 months after final treatment was graded as poor (< 50%), moderate (50–75%), good (> 75%) and excellent where the skin of the lesion returned normal as the rest of the surrounding skin. All treated nevi showed good to excellent cosmetic outcomes after 2 or 4 treatment sessions. The post laser complication were minimal and transit except for one atrophic scar. No recurrence of pigmentation during the six months of follow-up period. Conclusion: Ultra-pulsed CO2 laser seems to be effective and associate with minimum adverse side effect in the treatment of small CMN and AMN.

Spontaneous Regression of Large Congenital Melanocytic Nevi, With a Halo Rim in 17 Children With Large Scalp and Trunk Nevi During 45 Years: A Review of the Literature

2018 ◽  
Vol 58 (3) ◽  
pp. 313-319 ◽  
Author(s):  
Andrew M. Margileth
Keyword(s):  
Quality Of Life ◽  
Spontaneous Regression ◽  
Diagnostic Value ◽  
Management Approach ◽  
Health Providers ◽  
Pediatric Dermatology ◽  
Melanocytic Nevi ◽  
Congenital Melanocytic Nevi

Background. Prior reports on large congenital melanocytic nevi (LCMN) do not provide a clear management approach to physicians to advise parents or patients. Whether the presence of a halo around the nevus can guide management has not been fully explored. Design. Children born with an LCMN were observed without active intervention. Objectives. (1) To guide physicians, health providers, and parents in the management of CMN. (2) To ascertain the value of the absence or presence of a halo component of the nevi. (3) To reaffirm the diagnostic value of dermoscopy for evaluation of CMN. Materials and Methods. This was a clinical study of 45 children referred to our pediatric dermatology clinics from 1971 to- 2018. Results and Outcome. Of 45 children, 9 were lost to follow-up and 36 were followed for 6 months to 47 years. In follow-up of 17 children with a scalp CMN, spontaneous regression occurred in 6 patients. In follow-up of 5 children with a trunk LCMN, spontaneous regression occurred in 1 patient and excisional surgery was done in 4 patients. Quality of life was excellent in 35 children, but poor in 1 patient during multiple injections and excisions. Conclusions. A conservative approach to management of children with CMN, large and small, is safe, cost-effective, and results in excellent quality of life and cosmetic outcomes. Dermoscopy, a simple in-office procedure, can reassure the examiner that the congenital nevus is benign. A halo rim was present in 12 (80%) of 15 scalp CMN. The presence of a halo rim appears predictive of future regression of a CMN in the scalp or trunk.

scholarly journals Giant Congenital Melanocytic Nevi (GCMN): Sebuah Laporan Kasus Langka

2021 ◽  
Vol 10 (1) ◽  
pp. 112
Author(s):  
Erico Lemuel Yonathan ◽  
Hari Darmawan
Keyword(s):  
Birth Weight ◽  
The Body ◽  
Normal Birth Weight ◽  
Melanocytic Nevi ◽  
Normal Birth ◽  
Medication Consumption ◽  
Giant Congenital Melanocytic Nevi ◽  
Congenital Melanocytic Nevi ◽  
Neurocutaneous Melanocytosis

Giant Congenital Melanocytic Nevi (GCMN) is a nevus which present at birth or arise within the first few weeks of life. Incidence of GCMN is estimated at below 1:20.000 newborns. Lesion of GCMN usually appears with a black or brownish plaque and may have abnormal borders, flat or protruding surface and hypertrichosis. Giant Congenital Melanocytic Nevi (GCMN) is associated with malignant melanoma and neurocutaneous melanocytosis. A male newborn baby is reported to have a giant black hairy plaque, with irregular shape in his head since born. Patient was born naturally, full term, and normal birth weight. The mother has no medication consumption and disease history during pregnancy. In our three years follow up, there are multiple black patches with smaller size in front right and left leg, and the back of the body. The GCMN treatment consists of surgical and non-surgical procedures, psychological support, and lifelong monitoring. In this case, further examination and observation are needed.

scholarly journals RARE-24. LARGE CONGENITAL MELANOCYTIC NEVI AND NEUROCUTANEOUS MELANOCYTOSIS: A RETROSPECTIVE CASE SERIES

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii447-iii447
Author(s):  
Ugur Sener ◽  
Elsie Ennin ◽  
Stephanie Suser ◽  
Ashfaq Marghoob ◽  
Sofia Haque ◽  
...  
Keyword(s):  
At Risk ◽  
Malignant Melanoma ◽  
Case Series ◽  
Leptomeningeal Disease ◽  
Melanocytic Nevi ◽  
Serial Imaging ◽  
Melanoma Diagnosis ◽  
Congenital Melanocytic Nevi ◽  
Neurocutaneous Melanocytosis

Abstract Neurocutaneous melanocytosis (NCM) is a rare disease characterized by excessive proliferation and deposition of melanocytes in the leptomeninges and brain parenchyma, occurring in children with large congenital melanocytic nevi (LCMN). Manifestations of NCM range from asymptomatic CNS melanin deposition to cranial neuropathies, seizures, and hydrocephalus. Patients with NCM are at risk for malignant melanoma. We conducted a retrospective, single-institution study of patients with LCMN evaluated at Memorial Sloan Kettering Cancer Center from June 2000 to January 2020. Of 55 patients studied, 15 had no radiographic NCM, and 40 had radiographic NCM at initial evaluation. MRI findings included: focal melanocytosis (33), diffuse leptomeningeal disease (4), solid melanoma (3). Malformations were identified in 13, including arachnoid cyst (4), congenital hydrocephalus (4), Dandy-Walker malformation (3), and tethered cord (1). Twenty-one patients completed imaging once and were followed clinically. Seventeen with serial imaging (10 with focal melanocytosis, 7 with normal MRI) remained stable over a median 24-month follow up (range: 1–124). Six had suspected radiographic progression of NCM without melanoma. Malignant melanoma developed in 11 patients, 5 with focal melanocytosis on initial imaging. Median time from focal melanocytosis identification to melanoma diagnosis was 80 months (range: 18–200). Median age at melanoma diagnosis was 9.9 years (range: 1.1–25.3). Median survival from melanoma diagnosis was 9.1 months (range: 1–60.4). Focal NCM on neuroaxis imaging does not predict time to transformation to malignant melanoma. Serial imaging is not indicated in absence of disease-modifying treatment. Clinical follow up of at-risk individuals is essential in early identification of complications.

Electron Microscopy of Human Gallstones

1971 ◽  
Vol 29 ◽  
pp. 296-297
Author(s):  
C. Wolpers ◽  
R. Blaschke
Keyword(s):  
Electron Microscopy ◽  
Room Temperature ◽  
Bile Pigment ◽  
X Ray Diffraction ◽  
Triclinic Crystal System ◽  
X Ray ◽  
Follow Up Study ◽  
Infra Red ◽  
Main Components

Scanning microscopy was used to study the surface of human gallstones and the surface of fractures. The specimens were obtained by operation, washed with water, dried at room temperature and shadowcasted with carbon and aluminum. Most of the specimens belong to patients from a series of X-ray follow-up study, examined during the last twenty years. So it was possible to evaluate approximately the age of these gallstones and to get information on the intensity of growing and solving.Cholesterol, a group of bile pigment substances and different salts of calcium, are the main components of human gallstones. By X-ray diffraction technique, infra-red spectroscopy and by chemical analysis it was demonstrated that all three components can be found in any gallstone. In the presence of water cholesterol crystallizes in pane-like plates of the triclinic crystal system.

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