Near-infrared image-guided super-selective intra-arterial infusion of high-dose cisplatin for squamous cell carcinoma on the lower lip

2017 ◽  
Vol 27 (2) ◽  
pp. 208-209
Author(s):  
Kenji Yokota ◽  
Takaaki Matsumoto ◽  
Yoshie Murakami ◽  
Masashi Akiyama
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Near Infrared ◽  
Infrared Image ◽  
High Dose ◽  
Arterial Infusion ◽  
Lower Lip ◽  
Image Guided

scholarly journals Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx

2020 ◽  
Vol 6 (4) ◽  
pp. 20200005
Author(s):  
Naoya Murakami ◽  
Seiichi Yoshimoto ◽  
Masakazu Uematsu ◽  
Tairo Kashihara ◽  
Kana Takahashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Tumour ◽  
Interstitial Brachytherapy ◽  
High Dose ◽  
Inferior Wall ◽  
Residual Tumour ◽  
Image Guided ◽  
Keratinizing Squamous Cell Carcinoma

High-dose-rate interstitial brachytherapy (HDR-ISBT) is relatively rarely applied for the head and neck cancer because of its anatomical complexity and difficulty of applicator placement. However, its dose distribution is more confined even better than intensity-modulated radiation therapy (IMRT) and can deliver a higher dose while sparing surrounding normal tissues. In this case report, the effectiveness of HDR-ISBT as a boost following IMRT for keratinizing squamous cell carcinoma of nasopharynx was presented. A 76-year-old female who suffered from cT3N0M0 keratinizing squamous cell carcinoma of the nasopharynx was treated with definitive concurrent chemoradiation therapy involving IMRT. However, physical examination and laryngoscope fibre finding showed evident residual tumour at 60 Gy of IMRT, then, boost HDR-ISBT was proposed. After delivering 66 Gy of IMRT, CT image-guided HDR-ISBT 4 Gy in a single fraction was performed under local anaesthesia and sedation. MRI taken 5 months after HDR-ISBT showed remarkable shrinkage of the primary tumour. After HDR-ISBT, the remaining session of IMRT was delivered from the next day until 70 Gy in 35 fractions. It was demonstrated that boost HDR-ISBT combined with IMRT for keratinizing squamous cell carcinoma of the nasopharynx was performed safely and showed favourable efficacy.

Near-Infrared Fluorescent Image-Guided Lymphatic Mapping in Esophageal Squamous Cell Carcinoma

2020 ◽  
Vol 27 (10) ◽  
pp. 3799-3807
Author(s):  
Haoyao Jiang ◽  
Haohua Teng ◽  
Yifeng Sun ◽  
Xufeng Guo ◽  
Rong Hua ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Near Infrared ◽  
Lymphatic Mapping ◽  
Image Guided ◽  
Fluorescent Image

scholarly journals Outcomes of Post-Operative Treatment with Concurrent Chemoradiotherapy (CRT) in High-Risk Resected Oral Cavity Squamous Cell Carcinoma (OCSCC): A Multi-Institutional Collaboration

2021 ◽  
Vol 28 (4) ◽  
pp. 2409-2419
Author(s):  
Arslan Babar ◽  
Neil M. Woody ◽  
Ahmed I. Ghanem ◽  
Jillian Tsai ◽  
Neal E. Dunlap ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Demographic Data ◽  
Disease Free Survival ◽  
Total Sample ◽  
High Dose ◽  
Pathologic Features

Adjuvant chemoradiation (CRT), with high-dose cisplatin remains standard treatment for oral cavity squamous cell carcinoma (OCSCC) with high-risk pathologic features. We evaluated outcomes associated with different cisplatin dosing and schedules, concurrent with radiation (RT), and the effect of cumulative dosing of cisplatin. An IRB-approved collaborative database of patients (pts) with primary OCSCC (Stage I–IVB AJCC 7th edition) treated with primary surgical resection between January 2005 and January 2015, with or without adjuvant therapy, was established from six academic institutions. Patients were categorized by cisplatin dose and schedule, and resultant groups compared for demographic data, pathologic features, and outcomes by statistical analysis to determine disease free survival (DFS) and freedom from metastatic disease (DM). From a total sample size of 1282 pts, 196 pts were identified with high-risk features who were treated with adjuvant CRT. Administration schedule of cisplatin was not significantly associated with DFS. On multivariate (MVA), DFS was significantly better in patients without perineural invasion (PNI) and in those receiving ≥200 mg/m2 cisplatin dose (p < 0.001 and 0.007). Median DFS, by cisplatin dose, was 10.5 (<200 mg/m2) vs. 20.8 months (≥200 mg/m2). Our analysis demonstrated cumulative cisplatin dose ≥200 mg/m2 was associated with improved DFS in high-risk resected OCSCC pts.

Squamous Cell Carcinoma Arising on a Congenital Fissure of the Lower Lip

Dermatology ◽  
1990 ◽  
Vol 180 (3) ◽  
pp. 171-173 ◽  
Author(s):  
S. Serrano ◽  
J. Aneiros ◽  
F. O’Valle ◽  
C. Martinez
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lower Lip

scholarly journals Expression of Glucose Transporters 1 and 3 in Metastatic and Non-Metastatic Lower Lip Squamous Cell Carcinoma

2014 ◽  
Vol 25 (5) ◽  
pp. 372-378 ◽  
Author(s):  
Clarissa Favero Demeda ◽  
Cyntia Helena Pereira de Carvalho ◽  
Ana Rafaela Luz de Aquino ◽  
Cassiano Francisco Weege Nonaka ◽  
Lélia Batista de Souza ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Glucose Uptake ◽  
Squamous Cell ◽  
Histological Grade ◽  
Glucose Transporters ◽  
Nodal Metastasis ◽  
Invasive Front ◽  
Lower Lip ◽  
Glut 1

This study aimed to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and 3 (GLUT-3) in metastatic and non-metastatic lower lip squamous cell carcinoma (LLSCC). Twenty LLSCCs with regional nodal metastasis and 20 LLSCCs without metastasis were selected. The distribution of staining and the percentage of GLUT-1 and GLUT-3 staining in each tumor core and at the deep invasive front were assessed. Most tumors (70%) exhibited peripheral staining for GLUT-1 in nests, sheets and islands of neoplastic cells, whereas predominantly central staining was observed for GLUT-3 (72.5%). A high percentage of GLUT-1-positive cells was observed at the deep invasive front and in the tumor core of metastatic and non-metastatic tumors (p>0.05). The percentage of GLUT-1-positive cells was much higher than that of GLUT-3-positive cells both in the deep invasive front (p<0.001) and in the tumor core (p<0.001) of LLSCCs. No significant differences in the percentage of GLUT-1- and GLUT-3-positive cells were observed according to nodal metastasis, clinical stage or histological grade of malignancy (p>0.05). In conclusion, the results of the present study suggest an important role of GLUT-1 in glucose uptake in LLSCCs, although this protein does not seem to be involved in the progression of these tumors. On the other hand, GLUT-3 expression may represent a secondary glucose uptake mechanism in LLSCCs.

Squamous cell carcinoma on the lower lip after using topical calcineurin inhibitor

2013 ◽  
Vol 11 (9) ◽  
pp. 868-870 ◽  
Author(s):  
Şule Güngör ◽  
Gonca Gökdemir ◽  
Nesimi Büyükbabani ◽  
Nilgun Bahçetepe
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Calcineurin Inhibitor ◽  
Lower Lip ◽  
Topical Calcineurin Inhibitor

scholarly journals Squamous cell carcinoma of lower lip reconstructed with bilateral fan flap

2019 ◽  
Vol 9 (1) ◽  
pp. 211
Author(s):  
Semmia Mathivanan ◽  
BhattD Supreet ◽  
MustafaI Merchant ◽  
NiranjanS Patil
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lower Lip

scholarly journals Surgery for recurrent lower lip carcinoma

1970 ◽  
Vol 6 (3) ◽  
pp. 375-378
Author(s):  
S Maharjan ◽  
M Bista ◽  
KC Toran ◽  
KD Joshi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Medical Journal ◽  
Case Report ◽  
Cell Carcinoma ◽  
Key Words ◽  
Squamous Cell ◽  
Lower Lip ◽  
Recurrent Squamous Cell Carcinoma ◽  
Lip Carcinoma ◽  
Deltopectoral Flap

A 38 year old gentleman presented with recurrent Squamos cell carcinoma of lower lip. He had earlier undergone previous surgeries and radiotherapy. At the time that he presented in KMCTH his lower lip area was much scarred and the tongue was shrunk and unavailable for vermilion reconstruction. This case report is an account of the various treatment carried out to reconstruct the lip. It was done with co-operation of the ENT department. Key words: Recurrent squamous cell carcinoma, Gillies fan flap, Deltopectoral flap, Delay of flaps doi: 10.3126/kumj.v6i3.1715 Kathmandu University Medical Journal (2008), Vol. 6, No. 3, Issue 23, 375-378

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