Long-term maintenance therapy for vulvar lichen sclerosus: the results of a randomized study comparing topical vitamin E with an emollient

2013 ◽  
Vol 23 (2) ◽  
pp. 189-194 ◽  
Author(s):  
Annarosa Virgili ◽  
Sara Minghetti ◽  
Alessandro Borghi ◽  
Monica Corazza
Keyword(s):  
Vitamin E ◽  
Maintenance Therapy ◽  
Randomized Study ◽  
Lichen Sclerosus ◽  
Term Maintenance ◽  
Vulvar Lichen Sclerosus

Novel Therapeutic Approaches and Targets for Treatment of Vulvar Lichen Sclerosus

2020 ◽  
Vol 22 (1) ◽  
pp. 99-114
Author(s):  
Alessandro Borghi ◽  
Monica Corazza
Keyword(s):  
Maintenance Treatment ◽  
English Literature ◽  
Lichen Sclerosus ◽  
Treatment Phase ◽  
Current Evidence ◽  
Systemic Treatments ◽  
Pubmed Database ◽  
Term Maintenance ◽  
Vulvar Lichen Sclerosus

Background: Vulvar Lichen Sclerosus (VLS) is a chronic inflammatory disease with a huge impact on a person’s quality of life. A correct therapy is required for relieving symptoms, reversing signs and preventing further anatomical changes. Objective: The main objective of the present paper is to provide suggestions for the best treatment approach, based on the available evidence. Treatment strategies are divided on the basis of the treatment phase, distinguishing options for initial, acute or attack treatment and those for long-term, maintenance treatment. Methods: An electronic search was performed using the National Library of Medicine PubMed database. All the studies evaluating treatment of vulvar lichen sclerosus published in the English literature were analyzed, including controlled studies, case series, guidelines and reviews. Results: Current evidence identifies ultra-potent and potent corticosteroids, administered for 12 weeks, as the first-line recommended treatment for active VLS. Topical calcineurin inhibitors, tacrolimus and pimecrolimus, are effective and safe alternatives. Long-term maintenance strategies aimed at preventing recurrences are required, after the initial treatment phase. Maintenance treatment mostly consists in topical corticosteroids, administered i) on an “as needed” basis (“reactive” scheme), ii) on a continuative regimen, iii) on a low-dose, intermittent regimen (“proactive” scheme). Further investigations are needed for better defining the placement of other options within the VLS therapeutic algorithm, including retinoids, physical and systemic treatments. Conclusion: The available evidence provides useful indications for the management of VLS. Both the identification of new therapeutic targets and the optimization of the available options represent the main objectives of future research.

Efficacious long-term maintenance therapy with pantoprazole (PAN) in patients with Zollinger-Ellison syndrome

2001 ◽  
Vol 120 (5) ◽  
pp. A613-A613
Author(s):  
P BORNMAN ◽  
K RADEBOLD ◽  
H DEBAERE ◽  
L VENTER ◽  
H HEINZE ◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Zollinger Ellison Syndrome ◽  
Term Maintenance

scholarly journals Substantiation of Using Pimecrolimus 1% Cream in Proactive Therapy of Children with Atopic Dermatitis

2021 ◽  
Vol 20 (5) ◽  
pp. 376-382
Author(s):  
Nikolay N. Murashkin ◽  
Roman A. Ivanov ◽  
Eduard T. Ambarchian ◽  
Roman V. Epishev ◽  
Alexander I. Materikin ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Maintenance Therapy ◽  
Skin Disease ◽  
Pediatric Population ◽  
Efficacy And Safety ◽  
Inflammatory Skin Disease ◽  
High Prevalence ◽  
Proactive Therapy ◽  
Term Maintenance

Atopic dermatitis (AtD) is multifactorial inflammatory skin disease with high prevalence in pediatric population. It is crucial to implement long-term maintenance therapy to prevent AtD exacerbations according to current clinical guidelines and expert reports. The article summarizes the results of the major studies on using pimecrolimus 1% cream. Its efficacy and safety in long-term proactive therapy of children with AtD are presented.

Lansoprazole for Long-Term Maintenance Therapy of Erosive Esophagitis: Double-Blind Comparison with Ranitidine

2008 ◽  
Vol 54 (5) ◽  
pp. 955-963 ◽  
Author(s):  
David A. Peura ◽  
James W. Freston ◽  
Marian M. Haber ◽  
Thomas O. Kovacs ◽  
Barbara Hunt ◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Erosive Esophagitis ◽  
Double Blind ◽  
Blind Comparison ◽  
Term Maintenance
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