Non-pigmenting fixed drug eruption caused by an over-the-counter non-steroidal anti-inflammatory drug: Drug-specific CD8+ T lymphocytes identified in peripheral blood

2012 ◽  
Vol 22 (5) ◽  
pp. 680-682 ◽  
Author(s):  
Takaaki Hanafusa ◽  
Hiroaki Azukizawa ◽  
Sayaka Matsumura ◽  
Yukako Murakami ◽  
Aya Tanaka ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Peripheral Blood ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Over The Counter ◽  
Inflammatory Drug ◽  
Cd8 T Lymphocytes ◽  
Fixed Drug ◽  
Anti Inflammatory

Nonsteroidal anti-inflammatory drugs-induced generalized fixed drug eruption: two cases

2011 ◽  
Vol 31 (2) ◽  
pp. 197-200 ◽  
Author(s):  
SG Bilgili ◽  
O Calka ◽  
AS Karadag ◽  
N Akdeniz ◽  
M Kosem
Keyword(s):  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report

2022 ◽  
pp. 6-11
Author(s):  
Risa Shimizu ◽  
Fumihiko Tsushima ◽  
Ruri Komiya ◽  
Yuko Yamagata ◽  
Hiroyuki Harada
Keyword(s):  
Drug Eruption ◽  
Repeated Administration ◽  
Menstrual Pain ◽  
Fixed Drug Eruption ◽  
Causative Drug ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Simplex Virus ◽  
Rule Out

Fixed drug eruption (FDE) is a type of drug reaction in which cutaneous or mucocutaneous lesions recur at the same site due to repeated administration of the causative drug. The most reported FDE-inducing drugs are nonsteroidal anti-inflammatory drugs (NSAIDs). We report a case of FDE associated with the use of NSAIDs for menstrual pain. A 33-year-old woman was referred to our department with blisters and soreness on her lips, tongue, and labial mucosa. The results of blood examination helped rule out herpes simplex virus infection, pemphigus, and pemphigoid. An FDE was suspected because these symptoms coincided with the use of NSAIDs for menstrual pain. Thus, the patient was advised not to use these NSAIDs but to use acetaminophen instead. No recurrence has been observed since the patient began avoiding these NSAIDs.

Flurbiprofen-induced generalized bullous fixed drug eruption

2013 ◽  
Vol 33 (1) ◽  
pp. 106-108 ◽  
Author(s):  
I Balta ◽  
H Simsek ◽  
GG Simsek
Keyword(s):  
Contact Dermatitis ◽  
Side Effect ◽  
Drug Eruption ◽  
Cutaneous Vasculitis ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Drug Related Side Effect ◽  
Erythematous Patch

Fixed drug eruption (FDE) is an unusual drug-related side effect that results in recurrent lesions whenever the causative drugs are used. FDEs usually occur as a single, sharply demarcated, round erythematous patch or plaque, occasionally with localized bullae. The most common offending agents include antimicrobials, nonsteroidal anti-inflammatory drugs, and antiepileptics. There are some reports where contact dermatitis and cutaneous vasculitis have been associated with the use of flurbiprofen. We present the case of a 50-year-old man with flurbiprofen-induced generalized bullous FDE. To the best of our knowledge, the most serious form of FDE, the generalized bullous FDE, to be caused by flurbiprofen has not been reported previously.

Topical Provocation in Fixed Drug Eruption from Nonsteroidal Anti-Inflammatory Drugs

2002 ◽  
Vol 1 (2) ◽  
pp. 81-86 ◽  
Author(s):  
Margarida Gonçalo ◽  
Hugo S. Oliveira ◽  
Bárbara Fernandes ◽  
Margarida Robalo-Cordeiro ◽  
Américo Figueiredo
Keyword(s):  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Tylenol or acetaminophen: a recurrent fixed drug eruption perpetuated through the use of inconsistent drug terminology

2021 ◽  
Vol 14 (8) ◽  
pp. e241908
Author(s):  
Daniel Federman ◽  
Jadry A Gruen ◽  
Naseema Merchant
Keyword(s):  
Electronic Medical Records ◽  
Medical Records ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Over The Counter ◽  
The Past ◽  
Fixed Drug ◽  
Viral Illness ◽  
History Of ◽  
Proximal Thigh

An 87-year-old man with a history of osteoarthritis presented with worsening knee pain. He was prescribed acetaminophen with codeine. A few days later, he developed a rash on his right buttock and proximal thigh, similar to a rash he experienced in the past when he took over-the-counter (OTC) acetamenophen and an unknown lozenge to treat a presumed viral illness. A fixed drug eruption (FDE) was diagnosed and the patient was asked to avoid Tylenol and other OTC lozenges. Tylenol was entered as an allergy in the electronic medical records. However, since Tylenol, not acetaminophen was listed in the allergy profile, the order for acetaminophen and codeine did not generate an alert for the prescribing physician. Additionally, the dispensing pharmacist did not question the prescribing physician and the patient, unaware that acetaminophen in the pain medication is the same drug as Tylenol, took it and developed recurrent FDE.

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