Different response rates between palmoplantar involvement and diffuse plaque psoriasis in patients treated with infliximab

2012 ◽  
Vol 22 (1) ◽  
pp. 133-135 ◽  
Author(s):  
Alexandra Maria Giovanna Brunasso ◽  
Matteo Puntoni ◽  
Chiara Delfino ◽  
Cesare Massone
Keyword(s):  
Plaque Psoriasis ◽  
Response Rates ◽  
Diffuse Plaque ◽  
Different Response

scholarly journals Feasibility and success rates of response enhancing strategies in a stepwise prevention program for cardiometabolic diseases in primary care

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Ilse F. Badenbroek ◽  
Marcus M. J. Nielen ◽  
Monika Hollander ◽  
Daphne M. Stol ◽  
Roderik A. Kraaijenhagen ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Prevention Program ◽  
Prevention Programs ◽  
Response Rates ◽  
Similar Response ◽  
Cardiometabolic Diseases ◽  
Integrate Study ◽  
Different Response ◽  
E Mail ◽  
Selective Prevention

Abstract Background Prevention programs for cardiometabolic diseases (CMD), including cardiovascular disease, diabetes mellitus and chronic kidney disease are feasible, but evidence for the cost-effectiveness of selective CMD prevention programs is lacking. Response rates have an important role in effectiveness, but methods to increase response rates have received insufficient attention. The aim of the current study is to determine the feasibility and the success rate of a variety of response enhancing strategies to increase the participation in a selective prevention program for CMD. Methods The INTEGRATE study is a Dutch randomised controlled trial to assess the effectiveness and cost-effectiveness of a stepwise program for CMD prevention. During the INTEGRATE study we developed ten different response enhancing strategies targeted at different stages of non-response and different patient populations and evaluated these in 29 general practices. Results A face-to-face reminder by the GP increased the response significantly. Digital reminders targeted at patients with an increased CMD risk showed a positive trend towards participation. Sending invitations and reminders by e-mail generated similar response rates, but at lower costs and time investment than the standard way of dissemination. Translated materials, information gatherings at the practice, self-management toolkits, reminders by telephone, information letters, local media attention and SMS text reminders did not increase the response to our program. Conclusions Inviting or reminding patients by e-mail or during GPs consultation may enhance response rates in a selective prevention program for CMD. Different response-enhancing strategies have different patient target populations and implementation issues, therefore practice characteristics need to be taken into account when implementing such strategies. Trial registration Dutch trial Register number NTR4277. Registered 26 November 2013.

Tazarotene/Betamethasone Dipropionate Cream in Patients with Plaque Psoriasis: Results of a Prospective, Multicenter, Observational Study

Dermatology ◽  
2020 ◽  
pp. 1-8
Author(s):  
Chunxia He ◽  
Hongzhong Jin ◽  
Xiguang Liu ◽  
Fengming Hu ◽  
Litao Zhang ◽  
...  
Keyword(s):  
Observational Study ◽  
Real World ◽  
Plaque Psoriasis ◽  
Adverse Reactions ◽  
Response Rates ◽  
The Body ◽  
Betamethasone Dipropionate ◽  
Efficacy And Safety ◽  
Local Skin ◽  
The Mean

<b><i>Background:</i></b> Topical agents are still the mainstay for the treatment of mild-to-moderate plaque psoriasis, in which fixed combinations play an important role. Tazarotene/betamethasone dipropionate (Taz/BD) cream is a novel fixed combination approved for treating plaque psoriasis in China, but its efficacy and safety have not been verified in a real-world environment. <b><i>Objectives:</i></b> The primary objective was to investigate the efficacy and safety of Taz/BD cream in treating plaque psoriasis. The secondary objectives were to assess its relapse after discontinuation and the efficacy and safety profiles during retreatment. <b><i>Methods:</i></b> A prospective, multicenter, large-scale observational study was conducted. Adult patients with chronic plaque psoriasis involving &#x3c;20% of the body surface area were enrolled. Taz/BD cream was applied once daily for 4 weeks. Patients who achieved ≥90% improvement in the Psoriasis Area and Severity Index (PASI) from baseline to week 4 were followed up to investigate relapse after drug withdrawal. Relapsed patients underwent another 4-week treatment. <b><i>Results:</i></b> In total, 2,299 eligible patients were enrolled, and 2,095 patients (91.1%) completed the 4-week study. The mean PASI improvement at week 4 was 53.7%, and the PASI 50/75 response rates were 62.5 and 26.8%, respectively. The mean PASI reduction in plaque induration, desquamation and erythema were 58.3, 61.0 and 40.0%, respectively (<i>p</i> &#x3c; 0.001). Adverse reactions occurred in 445 patients (20.8%) at week 4. The most frequently reported adverse reactions were local skin irritation, including pruritus (10%), pain (6.7%), erythema (6.1%) and desquamation (1.8%). During the post-treatment period, 47 patients (24.0%) relapsed within 8 weeks after drug discontinuation. Forty-five patients were retreated for another 4 weeks, and the PASI 50/75 response rates were 72.7 and 40.9%, respectively. There were no unexpected safety signals during retreatment. <b><i>Conclusion:</i></b> Taz/BD cream is effective and well tolerated in treating mild-to-moderate plaque psoriasis under near real-world conditions and demonstrates efficacy and safety during retreatment.

scholarly journals Comparison of Survey Modality and Response Rate in Dermatologists’ Perceptions and Opinions of Sunscreens

2018 ◽  
Vol 2 (2) ◽  
pp. 122-126
Author(s):  
Alex M Glazer ◽  
Aaron S Farberg ◽  
Ryan M Svoboda ◽  
Darrell S Rigel
Keyword(s):  
Response Rate ◽  
Sun Exposure ◽  
Response Rates ◽  
Target Population ◽  
Vitamin D Supplementation ◽  
Audience Response ◽  
Variable Response ◽  
Significant Difference ◽  
Different Response ◽  
Scientific Survey

Background. Survey instruments are valuable tools for research and provide insight into real-world practice and areas of knowledge deficits in ways that traditional observational studies and randomized trials cannot. Despite some experts espousing survey response rates ≥60% as valid, there is no consensus as to what an adequate response rate is for a scientific survey. Furthermore, little is known what effect the interaction of survey administration modality and response rate has on results. Objective. To compare the results of differing survey modalities (which typically feature different response rate ranges). Methods. A validated, 21-item survey assessing perceptions of, recommendations regarding, and usage of sunscreen was distributed to three samples of dermatologists using three different modalities: pen/paper via mail, online via email, and in real-time via an audience response system at a national conference. Results. Response rates varied widely by survey modality (30% mail, 9% email 95% live). However, dermatologists’ responses to individual survey questions were largely consistent across modalities, with a statistically significant difference seen for only three questions (recommending sunscreens based on cosmetic elegance, recommending sunscreens based on photostability, and recommending vitamin D supplementation as a means to avoid sun exposure.  Conclusions. In this study evaluating dermatologists’ perceptions of, recommendations for, and personal use of sunscreen, survey results were largely consistent across three different modalities (mail, email, live) despite widely variable response rates, from 9% to 95%. These results suggest that when a scientific survey sample is representative of the target population, minimum response rate and survey modality appear to have negligible impact on results.

Different response rates for wild type and precore mutant HBV to interferon (IFN) treatment

1995 ◽  
Vol 108 (4) ◽  
pp. A1031
Author(s):  
Y. Bayraktar ◽  
T. Koseo-Glu ◽  
B. Uzunalimoglu ◽  
B. Kayhan ◽  
A. Gurakar ◽  
...  
Keyword(s):  
Response Rates ◽  
Wild Type ◽  
Ifn Treatment ◽  
Different Response ◽  
Precore Mutant

scholarly journals No warning for slow transitions

2021 ◽  
Vol 18 (176) ◽  
Author(s):  
Bregje van der Bolt ◽  
Egbert H. van Nes ◽  
Marten Scheffer
Keyword(s):  
Time Series ◽  
Response Rate ◽  
Warning Signal ◽  
Response Rates ◽  
Tipping Point ◽  
Climate Forcing ◽  
Slowing Down ◽  
Critical Transitions ◽  
Resilience Indicators ◽  
Different Response

A rise in fragility as a system approaches a tipping point may be sometimes estimated using dynamical indicators of resilience (DIORs) that measure the characteristic slowing down of recovery rates before a tipping point. A change in DIORs could be interpreted as an early warning signal for an upcoming critical transition. However, in order to be able to estimate the DIORs, observational records need to be long enough to capture the response rate of the system. As we show here, the required length of the time series depends on the response rates of the system. For instance, the current rate of anthropogenic climate forcing is fast relative to the response rate of some parts of the climate system. Therefore, we may expect difficulties estimating the resilience from modern time series. So far, there have been no systematic studies of the effects of the response rates of the dynamical systems and the rates of forcing on the detectability trends in the DIORs prior to critical transitions. Here, we quantify the performance of the resilience indicators variance and temporal autocorrelation, in systems with different response rates and for different rates of forcing. Our results show that the rapid rise of anthropogenic forcing to the Earth may make it difficult to detect changes in the resilience of ecosystems and climate elements from time series. These findings suggest that in order to determine with models whether the use of the DIORs is appropriate, we need to use realistic models that incorporate the key processes with the appropriate time constants.

Stress, Social Support, Emotional Regulation, and Exacerbation of Diffuse Plaque Psoriasis

2005 ◽  
Vol 46 (6) ◽  
pp. 556-564 ◽  
Author(s):  
A. Picardi ◽  
E. Mazzotti ◽  
P. Gaetano ◽  
M.S. Cattaruzza ◽  
G. Baliva ◽  
...  
Keyword(s):  
Social Support ◽  
Plaque Psoriasis ◽  
Emotional Regulation ◽  
Diffuse Plaque
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