Autologous serum skin test vs autologous plasma skin test in patients with chronic urticaria: evaluation of reproducibility, sensitivity and specificity and relationship with disease activity, quality of life and anti-thyroid antibodies

2011 ◽  
Vol 21 (3) ◽  
pp. 339-343 ◽  
Author(s):  
Emek KOCATÜRK ◽  
Mukaddes KAVALA ◽  
Esra KURAL ◽  
Sukran SARİGUL ◽  
Ilkin ZİNDANCİ
Keyword(s):  
Quality Of Life ◽  
Disease Activity ◽  
Skin Test ◽  
Sensitivity And Specificity ◽  
Chronic Urticaria ◽  
Autologous Serum ◽  
Thyroid Antibodies ◽  
Autologous Plasma ◽  
Autologous Serum Skin Test

scholarly journals Quality of Life Based on Autologous Serum Skin Test Result in Chronic Spontaneous Urticaria Patients

2021 ◽  
Vol 4 (1) ◽  
pp. 24-29
Author(s):  
Mahvira Chow Liana Herman Adil ◽  
Nopriyati Nopriyati ◽  
Desi Oktariana ◽  
Yuli Kurniawati ◽  
Gita Dwi Prasasty
Keyword(s):  
Quality Of Life ◽  
Skin Test ◽  
Outpatient Clinic ◽  
Chronic Spontaneous Urticaria ◽  
Autologous Serum ◽  
Bivariate Analysis ◽  
Female Group ◽  
Cross Sectional ◽  
Autologous Serum Skin Test

Several studies regarding the quality of life of chronic spontaneous urticaria patients based on Autologous Serum Skin Test (ASST) results have shown a variety of results. This study aims to determine the correlation between the quality of life and ASST results in chronic spontaneous urticaria patients at Dermatology and Venereology (DV) Outpatient Clinic of Dr. Mohammad Hoesin Hospital Palembang. This analytic observational study with a cross-sectional design used secondary data in the form of medical records. 76 samples met the inclusion criteria from 110 samples of chronic spontaneous urticaria patients at DV outpatient clinic. The distribution of chronic spontaneous urticaria patients was highest in the 17-25 year age group (23.7%) and the female group (64.5%). The majority of chronic spontaneous urticaria patients had negative ASST results (52.6%). The effect of chronic spontaneous urticaria on the decline in quality of life was mostly moderate (35.5%). The bivariate analysis between DLQI score and ASST results with a value of p = 0.307 or p> 0.05 showed no significant correlation between the quality of life and ASST results.

Treatment of chronic spontaneous urticaria with high doses of antihistamines

2016 ◽  
Vol 19 (6) ◽  
pp. 340-345
Author(s):  
Olga A. Kosoukhova ◽  
N. G Kochergin ◽  
P. V Kolkhir
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Clinical Symptoms ◽  
Individual Performance ◽  
Clinical Severity ◽  
Autologous Serum ◽  
Autologous Serum Skin Test ◽  
High Doses ◽  
Medical University

Urticaria is a group of diseases, the main clinical symptoms of which are transient rashes characterized not only by itch but skin edema, erythema, arising in any area of the skin, andfull resolution up to 24 hours. Urticaria is observed at least once in life of the 15-25% of the population, 25% of this patients have the chronic form of the disease. The aim of our work was the optimization of treatment of chronic urticaria by the second-generation antihistamine levocetirizine in standard and high daily dosages (up to fourfold), the study of clinical, allergo-logical and immunological characteristics of the results. The study involved 60 patients between the ages of 18 to 73 years with confirmed clinical diagnosis of chronic urticaria. The study was conducted in the clinic of skin and venereal diseases of I.M. Sechenov First Moscow State Medical University. Clinical and anamnestic examination, laboratory tests, autologous serum skin test were performed. The study was conducted within 1 month and included diagnostic consultation period and 5 consultations every 7 days. The obtained data were used to generate optimized approaches to the treatment of patients with chronic urticaria with regard to the form and severity level of the disease. Optimally assigned differentiated dosages of antihistamines, based on individual performance autologous serum skin test and severity of the clinical picture of urticaria, equally lead to a reduction of clinical severity and improve quality of life of patients with chronic urticaria.

The autologous serum skin test in the follow-up of patients with chronic urticaria

Allergy ◽  
2005 ◽  
Vol 60 (2) ◽  
pp. 256-258 ◽  
Author(s):  
A. Fusari ◽  
C. Colangelo ◽  
F. Bonifazi ◽  
L. Antonicelli
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Autologous Serum ◽  
Autologous Serum Skin Test

scholarly journals Autologous Serum Skin Test for Initial Identification of Auto- Antibodies in Chronic Urticaria

2018 ◽  
Vol 19 (2) ◽  
pp. 100-103
Author(s):  
Mohammad Nura Alam ◽  
Mohammad Ali ◽  
Mohammad Moniruzzaman Khan ◽  
Keya Tarafder ◽  
Goutam Kumar Acherjya ◽  
...  
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Cost Effective ◽  
Autologous Serum ◽  
P Value ◽  
Effective Measure ◽  
Autologous Serum Skin Test ◽  
Physical Urticaria ◽  
Retrospective Data Analysis ◽  
Initial Identification

Background: Autologous serum skin test (ASST) is easy to perform, cost effective measure for initial identification of auto-antibody in patients suffering from chronic urticaria which may occur due to autoimmune trigger by spontaneously developed auto-antibodies against FcμRI receptor of skin mast cells.Objective: This review is designed to see the positivity of ASST in patients suffering from chronic urticaria.Materials & Methods: This a retrospective data analysis conducted from the records of patients suffered from at least two episodes of urticaria or more in a week for 6 weeks and who did ASST aged more than 10 years between July 2015 to June 2017. These subjects were not pregnant or lactating mother, did not had urticarial vasculitis, predominant co-existing physical urticaria and had negative Hepatitis B antigen and anti-nuclear antibody reports.Results: Total 53 were included in this study of them 33 were female. Mean age was 32 years with a standard deviation (SD) of 11 years. Among study patients 16 (30.2% of total) had a positive ASST result. No age or sex difference was observed in positive ASST cases. In positive cases significant (p-value:<0.001) mean induration difference of 2.75mm with a SD of 1.00 mm observed than induration produced by negative control.Conclusion: ASST is easy and effective tool for initial identification of auto-reactive urticaria.J MEDICINE JUL 2018; 19 (2) : 100-103

Autologous Whole Blood Injections to Patients with Chronic Urticaria and a Positive Autologous Serum Skin Test: A Placebo-Controlled Trial

Dermatology ◽  
2006 ◽  
Vol 212 (2) ◽  
pp. 150-159 ◽  
Author(s):  
P. Staubach ◽  
K. Onnen ◽  
A. Vonend ◽  
M. Metz ◽  
F. Siebenhaar ◽  
...  
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Whole Blood ◽  
Controlled Trial ◽  
Autologous Serum ◽  
Autologous Serum Skin Test ◽  
Autologous Whole Blood

scholarly journals HLA among Brazilian patients with spontaneous chronic urticaria and positive autologous serum skin test

2012 ◽  
Vol 87 (4) ◽  
pp. 578-583 ◽  
Author(s):  
Zamir Calamita ◽  
Andrea Bronhara Pelá ◽  
Márcia Gamberini ◽  
Wilson Baleotti Júnior ◽  
Odilon Marques de Almeida Filho ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Skin Test ◽  
Chronic Urticaria ◽  
Population Group ◽  
Autologous Serum ◽  
Major Histocompatibility ◽  
Allele Distribution ◽  
Autologous Serum Skin Test ◽  
Histocompatibility Complex ◽  
Oligonucleotide Hybridization

BACKGROUND: An association between class I and II alleles of the major histocompatibility complex and idiopathic chronic urticaria has previously been observed in different populations, but there are still no studies on Brazilian populations in this regard. OBJECTIVE: The involvement of the major histocompatibility complex classes I and II (loci A, B and DR) in Brazilian patients with idiopathic chronic urticaria and a positive autologous serum skin test was investigated and compared with a healthy population group. METHODS: DNA was extracted from the blood of 42 patients with idiopathic chronic urticaria and major histocompatibility complex classes I and II alleles were determined using the polymerase chain reaction and a laboratory test for oligonucleotide hybridization using a single-filament probe. The frequencies of these alleles in patients with chronic urticaria were compared with the frequencies in 1000 genetically unrelated voluntary blood donors from the same region of Brazil. The diagnosis of idiopathic chronic urticaria was based on the patients' clinical history and routine laboratory tests. Only the patients with positive autologous serum skin test were selected. The allele distribution resulted from the patient and control groups were analyzed using odds ratios and 95% confidence intervals. RESULTS: No statistically significant differences were found between the positive autologous serum skin test patients with chronic urticaria and the control group. CONCLUSIONS: We found that in this population group, there was no specific association between the HLA alleles studied and chronic urticaria. We believe that further population studies are needed in order to investigate the possible existence of this association.

scholarly journals A study of autologous serum skin test and autologous serum therapy in chronic urticaria

2018 ◽  
Vol 4 (2) ◽  
pp. 246
Author(s):  
Bharti Patel ◽  
Komal Kapadia ◽  
Khushbu Chauhan ◽  
Neela Bhuptani
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Quality Index ◽  
Life Quality ◽  
Autologous Serum ◽  
Effective Parameters ◽  
Positive Skin ◽  
Autologous Serum Skin Test ◽  
Before And After ◽  
Life Quality Index

<p class="abstract"><strong>Background:</strong> Chronic urticaria (CU) is a vexing problem and patients suffer from the morbidity that arise from irritable itch and wheals and are also subjected to a huge antihistamine pill burden. A subset of patients with CU may have an autoimmune basis for their condition, as shown by a positive skin test to ASST. The objective of the study was to compare efficacy of AST in ASST positive and negative patients and its impact on dermatology life quality index (DLQI) in patients, before and after AST.</p><p class="abstract"><strong>Methods:</strong> A prospective, interventional study was conducted in the Department of dermatology (Skin) OPD of our institute from October 2016 to October 2017. Fifty patients were selected randomly and antihistaminics were withdrawn before ASST. Test was performed in all patients and AST was given for 9 weeks in both (ASST positive &amp; negative) groups, along with tablet levocetrizine on demand basis and followed for 4 weeks after completion of 9 weeks of therapy. Total severity score (TSS), urticaria activity score (UAS), dermatologic life quality index (DLQI) were used as primary effective parameters and were recorded at baseline and weekly after each injections of AST.<strong></strong></p><p class="abstract"><strong>Results:</strong> UAS and TSS showed significant improvement (&gt;50%) after 5th week in both group patients. DLQI showed higher improvement in ASST positive patients.</p><p class="abstract"><strong>Conclusions:</strong> We found significant improvement in ASST positive and ASST negative patients but ASST positive patients required more time to experience the benefit of AST.</p><p class="abstract"> </p>

scholarly journals Association between Clinico-epidemiological Features in Chronic Urticaria with Autologous Serum Skin Test: A Cross-sectional Observational Study

2021 ◽  
Author(s):  
Usha Rani Tirupathi ◽  
Bhagya Rekha Manchiryala ◽  
Sruthi Kareddy
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Autologous Serum ◽  
Clinical Test ◽  
Cross Sectional ◽  
Autologous Serum Skin Test ◽  
Epidemiological Features ◽  
Chronic Inducible Urticaria ◽  
Autoimmune Urticaria ◽  
Significant Difference

Introduction: Urticaria is a frequent and heterogeneous skin disease characterised by the development of wheals (hives), angioedema, or both. Chronic urticaria is characterised by the occurrence of wheals lasting less than 24 hours, with or without angioedema occurring daily or almost daily lasting more than six weeks. The two subtypes of chronic urticaria are Chronic Spontaneous Urticaria (CSU) and Chronic Inducible Urticaria (CIU). Autologous Serum Skin Test (ASST) is the simplest and the best in-vivo clinical test for the detection of basophil histamine- releasing activity. ASST has a sensitivity of approximately 70% and a specificity of 80%. Aim: To study the association between clinico-epidemiological features of CSU with positive and negative ASST. Materials and Methods: The cross-sectional study was conducted on 80 clinically diagnosed cases of CSU attending the Department of Dermatology Venereology Leprology Outpatient Department at Mahatma Gandhi Memorial Hospital (Kakatiya Medical College), Warangal, Telangana, India; during the period of January 2016 to September 2017. The detailed history was taken; complete physical and cutaneous examination and laboratory investigations like Complete Blood Picture (CBP), Absolute Eosinophil Count (AEC), Erythrocytic Sedimentation Rate (ESR), Thyroid Function Test (TFT) were carried out. ASST was done and read after 30 minutes. Chi- square test was applied and the results analysed using Statistical Package for the Social Sciences (SPSS) version 10.0. Results: Out of total 80 patients included in the study, ASST was positive in 36 (45%) and negative in 44 (55%). ASST positive patients showed longer duration of the disease with increased frequency of attacks and longer duration of wheals. However, both ASST positive and negative groups did not show statistically significant difference in the age of occurrence, gender, angioedema, dermographism. Conclusion: Autoimmune urticaria has no distinctive clinical features. ASST positive, autoimmune urticaria patients have more severe disease with greater impact on quality of life. Thus, they may need more aggressive treatment.

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