CD4+/CD56+ hematodermic neoplasm

2011 ◽  
Vol 21 (2) ◽  
pp. 291-292
Author(s):  
Marta CARLESIMO ◽  
Elena MARI ◽  
Giorgia CORTESI ◽  
Diego ORSINI ◽  
Alessandra NARCISI ◽  
...  
Keyword(s):  
Hematodermic Neoplasm

A case of CD4+/CD56+ hematodermic neoplasm (plasmacytoid dendritic cell neoplasm)

2010 ◽  
Vol 16 (4) ◽  
Author(s):  
Ozlem Su ◽  
Nahide Onsun ◽  
Cuyan Demirkesen ◽  
Yildiz Aydin ◽  
Serpil Pirmit ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cell ◽  
Cell Neoplasm ◽  
Hematodermic Neoplasm

Gene-expression profiling and array-based CGH classify CD4+CD56+ hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities

Blood ◽  
2006 ◽  
Vol 109 (4) ◽  
pp. 1720-1727 ◽  
Author(s):  
Remco Dijkman ◽  
Remco van Doorn ◽  
Károly Szuhai ◽  
Rein Willemze ◽  
Maarten H. Vermeer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiling ◽  
Molecular Mechanisms ◽  
Expression Profiles ◽  
Plasmacytoid Dendritic Cell ◽  
Chromosome 9 ◽  
Comparative Genomic ◽  
Genomic Amplification ◽  
Myelomonocytic Leukemia ◽  
Hematodermic Neoplasm

Abstract CD4+CD56+ hematodermic neoplasm (CD4+CD56+HN) is an aggressive hematopoietic malignancy with distinct clinicopathologic and immunophenotypic features that commonly involve the skin, bone marrow, and blood. Differentiation from cutaneous myelomonocytic leukemia (c-AML) may be exceedingly difficult and requires extensive phenotyping. The molecular mechanisms involved in the development of CD4+CD56+HN are largely unresolved. Moreover, recurrent chromosomal alterations have not yet been precisely defined in CD4+CD56+HN and c-AML. In the present study an integrated genomic analysis using expression profiling and array-based comparative genomic hybridization (CGH) was performed on lesional skin biopsy samples of patients with CD4+CD56+HN and c-AML. Our results demonstrate that CD4+CD56+HN and c-AML show distinct gene-expression profiles and distinct patterns of chromosomal aberrations. CD4+CD56+HN is characterized by recurrent deletion of regions on chromosome 4 (4q34), chromosome 9 (9p13-p11 and 9q12-q34), and chromosome 13 (13q12-q31) that contain several tumor suppressor genes with diminished expression (Rb1, LATS2). Elevated expression of the oncogenes HES6, RUNX2, and FLT3 was found but was not associated with genomic amplification. We noted high expression of various plasmacytoid dendritic-cell (pDC)–related genes, pointing to the cell of origin of this malignancy.

scholarly journals A cace of CD4+/CD56+ hematodermic neoplasm

Skin Cancer ◽  
2006 ◽  
Vol 21 (2) ◽  
pp. 125-131 ◽  
Author(s):  
Daisuke SUZUKI ◽  
Kenji ASAGOE ◽  
Eiichi MAKINO ◽  
Hiroko MAYUMI ◽  
Reiko OFUJI ◽  
...  
Keyword(s):  
Hematodermic Neoplasm

scholarly journals CD4-/CD56+/CD123+ Hematodermic Neoplasm Showing Early Liver Metastasis

2010 ◽  
Vol 22 (2) ◽  
pp. 186 ◽  
Author(s):  
Kyu-Won Choi ◽  
Ki-Yeol Lee ◽  
Yeong-Kyu Lee ◽  
Bon-Seok Ku ◽  
Hong-Seok Kim ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Hematodermic Neoplasm

scholarly journals CD4-negative variant of CD4+/CD56+ hematodermic neoplasm: description of three cases

2008 ◽  
Vol 35 (10) ◽  
pp. 911-915 ◽  
Author(s):  
Stefano Ascani ◽  
Cesare Massone ◽  
Gerardo Ferrara ◽  
Franco Rongioletti ◽  
Manuela Papini ◽  
...  
Keyword(s):  
Hematodermic Neoplasm
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