Experimental colitis in rats induces de novo synthesis of cytokines at distant intestinal sites: role of capsaicin-sensitive primary afferent fibers

2016 ◽  
Vol 27 (2) ◽  
pp. 41-53 ◽  
Author(s):  
Fadi.H. Mourad ◽  
Tamim. Hamdi ◽  
Kassem.A. Barada ◽  
Nayef.E. Saadé
Keyword(s):  
De Novo ◽  
Experimental Colitis ◽  
De Novo Synthesis ◽  
Primary Afferent ◽  
Afferent Fibers ◽  
Primary Afferent Fibers

Role of capsaicin-sensitive afferent nerves in initiation and maintenance of pathological pain

1997 ◽  
Vol 20 (3) ◽  
pp. 454-455 ◽  
Author(s):  
Gábor Jancsó ◽  
Mária Dux ◽  
Péter Sántha
Keyword(s):  
Critical Role ◽  
Primary Afferent ◽  
Peripheral Nerve Damage ◽  
Afferent Nerves ◽  
Afferent Fibers ◽  
Primary Afferent Fibers ◽  
Pathological Pain ◽  
Ganglion Neurons ◽  
Afferent Terminals

This commentary provides experimental data in support of the critical role of capsaicin-sensitive primary afferent fibers in the initiation and maintenance of pathological pain. The demonstration of capsaicin-induced, centrally-evoked cutaneous hyperalgesia, and of neuroplastic changes elicited by the degeneration of C-fiber primary afferent terminals following peripheral nerve damage, indicates a significant contribution of capsaicin-sensitive sensory ganglion neurons in the development of pathological pain conditions. [coderre & katz]

Involvement of capsaicin-sensitive primary afferent fibers in regulation of jejunal alanine absorption

1995 ◽  
Vol 268 (4) ◽  
pp. G695-G699 ◽  
Author(s):  
C. F. Nassar ◽  
K. A. Barada ◽  
L. E. Abdallah ◽  
W. S. Hamdan ◽  
A. M. Taha ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Dependent Manner ◽  
Primary Afferent ◽  
In Vivo Experiments ◽  
Afferent Fibers ◽  
Cervical Vagotomy ◽  
Primary Afferent Fibers

Capsaicin-sensitive primary afferent fibers (CSPA) in the small intestine regulate many functions through the release of peptides and neurotransmitters. This study was undertaken to assess the role of CSPA in the regulation of jejunal alanine absorption in the rat. In a series of in vivo experiments, the effects of the sensory neurotoxin capsaicin on small intestinal alanine absorption were evaluated. In vitro experiments were also done to study its effects on alanine uptake by isolated jejunal strips and mucosal scrapings. Jejunal alanine absorption was reduced by 27% when capsaicin (160 and 800 microM) was perfused intraluminally and by 21% when it was applied topically to the cervical vagi. On the other hand, bilateral cervical vagotomy and reversible block of vagal CSPA increased alanine absorption by 29 and 41%, respectively. In vitro, capsaicin reduced alanine uptake by intestinal strips in a dose-dependent manner. Maximal inhibition (36.5%) occurred at 400 microM with the mean ineffective concentration at 87 microM. Alanine uptake by jejunal mucosal scrapings, however, was decreased only by 6.7% when incubated with 1,600 microM capsaicin. These data suggest that vagal CSPA exerts a tonic inhibitory effect on alanine absorption and that capsaicin's inhibitory effect on alanine absorption is mediated largely by the capsaicin-sensitive afferent fibers.

scholarly journals Opioid Actions in Primary-Afferent Fibers—Involvement in Analgesia and Anesthesia

2011 ◽  
Vol 4 (2) ◽  
pp. 343-365 ◽  
Author(s):  
Eiichi Kumamoto ◽  
Kotaro Mizuta ◽  
Tsugumi Fujita
Keyword(s):  
Primary Afferent ◽  
Afferent Fibers ◽  
Primary Afferent Fibers
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