Accumulation of p53 protein and overexpression of the HER3 receptor in colorectal cancer

2015 ◽  
Vol 73 (2) ◽  
pp. 158-164
Author(s):  
Siham Amsaguine ◽  
Sara El Mhaia ◽  
Houda Drissi ◽  
Chrifa Amer ◽  
Mohammed Ahallat ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
P53 Protein ◽  
Her3 Receptor

p53 protein accumulation and p53 gene mutation in colorectal cancer

2000 ◽  
Vol 6 (4) ◽  
pp. 275-279 ◽  
Author(s):  
Anna Nasierowska-Guttmejer ◽  
Lech Trzeciak ◽  
Marek P. Nowacki ◽  
Jerzy Ostrowski
Keyword(s):  
Colorectal Cancer ◽  
Gene Mutation ◽  
P53 Protein ◽  
P53 Gene ◽  
Protein Accumulation ◽  
P53 Gene Mutation

scholarly journals Protein Expression Profiling Identifies Key Proteins and Pathways Involved in Growth Inhibitory Effects Exerted by Guggulsterone in Human Colorectal Cancer Cells

Cancers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1478 ◽  
Author(s):  
Leo ◽  
Therachiyil ◽  
Siveen ◽  
Uddin ◽  
Kulinski ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
P53 Protein ◽  
Colorectal Cancer Cell Line ◽  
Proteomic Profiling ◽  
Human Colorectal Cancer ◽  
Altered Expression ◽  
Apoptosis Pathway ◽  
Intrinsic Apoptosis Pathway ◽  
Hct 116

Colorectal cancer (CRC) is a leading killer cancer worldwide and one of the most common malignancies with increasing incidences of mortality. Guggulsterone (GS) is a plant sterol used for treatment of various ailments such as obesity, hyperlipidemia, diabetes, and arthritis. In the current study, anti-cancer effects of GS in human colorectal cancer cell line HCT 116 was tested, potential targets identified using mass spectrometry-based label-free shotgun proteomics approach and key pathways validated by proteome profiler antibody arrays. Comprehensive proteomic profiling identified 14 proteins as significantly dysregulated. Proteins involved in cell proliferation/migration, tumorigenesis, cell growth, metabolism, and DNA replication were downregulated while the protein with functional role in exocytosis/tumor suppression was found to be upregulated. Our study evidenced that GS treatment altered expression of Bcl-2 mediated the mitochondrial release of cytochrome c which triggered the formation of apoptosome as well as activation of caspase-3/7 leading to death of HCT 116 cells via intrinsic apoptosis pathway. GS treatment also induced expression of p53 protein while p21 expression was unaltered with no cell cycle arrest. In addition, GS was found to inhibit NF-kB signaling in colon cancer cells by quelling the expression of its regulated gene products Bcl-2, cIAP-1, and survivin.

p53 protein overexpression and response to biomodulated 5-fluorouracil chemotherapy in patients with advanced colorectal cancer

1996 ◽  
Vol 22 (2) ◽  
pp. 182-185 ◽  
Author(s):  
Martin C. Brett ◽  
Mark Pickard ◽  
Bryan Green ◽  
Amanda Howel-Evans ◽  
David Smith ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Advanced Colorectal Cancer ◽  
P53 Protein ◽  
Protein Overexpression

Value of P53 Protein Expression and its Relationship with Short-Term Prognosis in Colorectal Cancer

2002 ◽  
Vol 22 (5-6) ◽  
pp. 377-380
Author(s):  
Yamaç Erhan ◽  
Mustafa Ali Korkut ◽  
Eray Kara ◽  
Hasan Aydede ◽  
Aslan Sakarya ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Protein Expression ◽  
P53 Protein ◽  
Short Term ◽  
P53 Protein Expression

Quantification and characterization of total cellular p53 protein in colorectal cancer

Cytometry ◽  
1998 ◽  
Vol 31 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Osamu Tominaga ◽  
Pascal Hammel ◽  
Richard Hamelin ◽  
Hirokazu Nagawa ◽  
Tetsuichiro Muto ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
P53 Protein

Relationship of P-glycoprotein and p53 protein to chemosensitivity in colorectal cancer

1997 ◽  
Vol 2 (2) ◽  
pp. 81-91 ◽  
Author(s):  
Keiko Yagi ◽  
Kazufumi Kunitomo ◽  
Kunio Ii ◽  
Seiki Tashiro
Keyword(s):  
Colorectal Cancer ◽  
P53 Protein ◽  
P Glycoprotein ◽  
Relationship Of
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