Thrombopathy induced by selective serotonin reuptake inhibitors: a case report

2014 ◽  
Vol 72 (5) ◽  
pp. 607-611
Author(s):  
Mehdi Ben Said ◽  
Laurence Amar ◽  
David Smadja ◽  
Nadia Rivet ◽  
Sébastien Bertil ◽  
...  
Keyword(s):  
Case Report ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin

Case-report and Review of Selective Serotonin Reuptake Inhibitors-induced Delirium in Older Adults

2016 ◽  
Vol 33 (S1) ◽  
pp. S473-S473 ◽  
Author(s):  
S. Petrykiv ◽  
L. de Jonge ◽  
M. Arts
Keyword(s):  
Older Adults ◽  
Case Report ◽  
Frail Elderly ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Medical Evidence ◽  
Late Life Depression ◽  
Competing Interest

IntroductionSelective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed antidepressants with generally fewer side effects than most other types of antidepressants. However, in frail elderly, the use of SSRIs was anecdotally reported as a potential cause of a delirium.ObjectivesTo present a case of citalopram-induced delirium in an older adult diagnosed with late-life depression.AimsTo review available literature on SSRI-induced delirium.MethodsA case report is presented and discussed, followed by a literature review.ResultsSeven published cases of SSRI-induced delirium in older adults (> 60 years) were found while searching through Pubmed and Embase. Our case of a 75-year-old female is also included in this report. This patient was ambulatory treated with citalopram 20 mg per os against depressive symptoms and she developed a delirium four days after the initiation of the therapy. Blood tests were normal and CT scan showed no significant findings. No other medical evidence was found that could explain her delirium. Her symptoms finally resolved after discontinuation of citalopram.ConclusionThe on- and off-treatment side-effect correlation by a segregate oral use of citalopram strongly suggests that SSRIs may have the potential to cause a delirium, especially in frail elderly. Further research on this topic is needed.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Non-epileptic seizure caused by selective serotonin reuptake inhibitors (SSRI) - case report

2021 ◽  
Author(s):  
André Douglas Marinho da Silva ◽  
Ana Caroline Fonseca Silva ◽  
Lucas Pablo Almendro ◽  
Pedro da Cunha Dantas
Keyword(s):  
Case Report ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Medication Management ◽  
Antidepressant Drugs ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Seizure Threshold ◽  
Seizure Event ◽  
Patient Reported

Context: Seizures are the most frequent clinical emergency neurological manifestation, corresponding to 1-5% of the visits, except for trauma. Several conditions have the potential to reduce the seizure threshold, and the use of antidepressant drugs as selective serotonin reuptake inhibitors is one of those reported. The seizure triggering risk related to SSRIs use is low, being 0.1%, perceptibly lower than that of tricyclic antidepressants, with a 1% rate. Case report: Male patient, previously healthy, 23-year-old, was seen at the Emergency Room in Rio Branco after a generalized seizure lasting 3 minutes. Complementary exams, including computed tomography, were all normal. Magnetic resonance imaging of the skull without atypical findings and electroencephalogram showed dysrhythmia by waves and discrete spicules. Patient reported using escitalopram (esc) 20mg for 3 months after 10mg progression dose, in use for 1 year, without clinical improvement. Due to the seizure event, medication management was switched for sertraline 50mg intake. After 2 months, the patient had a new generalized seizure, preceded by prolonged depersonalization. Complementary exams were normal, 10mg of esc was reestablished and the patient ceased with the seizures. Conclusions: The diagnostic hypothesis: patient’s seizure threshold is low, and seizures are triggered by SSRI higher doses adverse effect. Due to case rarity and SSRI efficacy and tolerance, it is suggested to encourage the discussion about administration safety of these drugs.

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