Weakening osteopathies, chronic kidney disease, malabsorption, biological anomalies of calium/phosphorus metabolism: appropriate indications for a reasoned reimbursment of serum vitamin D measurement

2014 ◽  
Vol 72 (4) ◽  
pp. 385-389
Author(s):  
Jean-Claude Souberbielle ◽  
Claude Laurent Benhamou ◽  
Bernard Cortet ◽  
Mickael Rousière ◽  
Christian Roux ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Serum Vitamin ◽  
Phosphorus Metabolism ◽  
Serum Vitamin D

STUDY THE SERUM VITAMIN D LEVELS IN PATIENTS OF CHRONIC KIDNEY DISEASE

2021 ◽  
pp. 1-3
Author(s):  
Brahmarshi Das ◽  
Narendranath Hait ◽  
Jayanta Kumar Rout ◽  
Debarshi Jana
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Newly Diagnosed ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Mean

INTRODUCTION: Chronic Kidney Disease (CKD) is dened as a disease characterized by alterations in either kidney structure or function or both for a minimum of 3 months duration. Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney 1 function over a period of months or years. Early on there are typically no symptoms. Later, leg swelling, feeling tired, vomiting, loss of appetite, or 1 confusion may develop. Complications may include heart disease, high blood pressure, bone disease, or anemia. AIM AND OBJECTIVES: Study of Prevalence of hypovitaminosis D in patients of chronic kidney diseases. Search for commonest etiology of hypovitaminosis D in CKD. MATERIALAND METHOD: A Cross-sectional study on 100 cases of newly diagnosed Chronic Kidney Disease patients and matched control subjects is undertaken to study the prevalence of Vitamin D deciency in CKD population and correlation between their serum 25-OH-vitamin D level. 100 Patients who are newly diagnosed as CKD are selected after proper initial screening at Midnapore Medical College, Paschim Medinipur. RESULT AND ANALYSIS: Our study showed that in non-dialysis Syndrome the mean VitD (mean± s.d.) of patients was 25.6620 ± 8.5476. In dialysis the mean VitD (mean± s.d.) of patients was 10.9476 ± 2.6508. Difference of mean VitD in Dialysis vs Non-Dialysis was statistically signicant (p<0.0001). In eGFR 1 (<15) the mean VitD (mean± s.d.) of patients was 11.1130 ± 2.9562. In eGFR2 (15-30) the mean VitD (mean± s.d.) of patients was 24.0750 ± 8.2995. In eGFR3 (31-45) the mean VitD (mean± s.d.) of patients was 26.8296 ± 7.3646. In eGFR4 (>45) the mean VitD (mean± s.d.) of patients was 36.3167 ± 4.9898. Difference of mean VitDin eGFR was statistically signicant (p<0.0001). SUMMARYAND CONCLUSION: Vitamin-D deciency more pronounced in advanced stages of CKD. Vitamin-D deciency was most prevalent in female gender, younger age group and connective tissue disorder. Vitamin-D deciency was more marked in hemodialysis patients compared to non-dialysis CKD patients.

scholarly journals Estimation of Serum Vitamin D, Calcium and Phosphorus in Chronic Kidney Disease

2017 ◽  
Vol 16 (1) ◽  
pp. 30-36
Author(s):  
Ajay Rajbhandari ◽  
Rajendra Kumar Agrawal ◽  
Anil Baral ◽  
Anil Pokhrel ◽  
Dineshwori Shrestha ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Serum Phosphorus ◽  
Phosphate Binders ◽  
Serum Vitamin D ◽  
Ckd Stage ◽  
Calcium And Phosphorus

Introduction: Abnormalities in mineral metabolism are invariable with progressive deterioration of kidney function in chronic kidney disease (CKD). These abnormalities are documented in CKD on dialysis in our population but not on pre dialysis. So, present study aims to estimate serum vitamin D, calcium and phosphorus in CKD stage 3-5ND. Methods: It was a cross sectional study of established new CKD patients not on dialysis, vitamin D, calcium, phosphate binders and corticosteroids therapy. Blood sample was drawn for estimation of serum vitamin D, creatinine, calcium, phosphorus and albumin and CKD staging done by KDIGO (2012) criteria. SPSS software version 19 was used for data analysis and chi-squared and ANOVA test was applied as the test of significance.Results: Sixty six (51 male and 15 female) CKD patients with a mean age of 54.3±14.8 years were studied. Hypovitaminosis D (<30 ng/ml) was present in 84.8%, with deficiency (<20 ng/ml) in 50% and insufficiency (20-30) ng/ml in 34.8%. Other abnormalities observed were hypocalcemia (60.6%), hypercalcemia (1.5%) and hyperphosphatemia (63.6%) with no difference of corrected calcium, significant difference of serum phosphorus (p<0.001) with hyperphosphatemia in stage 4 and 5 CKD and vitamin D insufficiency in stage 3b, deficiency in stage 3a, 4 and 5 CKD. There was no correlation of serum vitamin D with calcium and phosphorus in different stages of CKD.Conclusion: Present study concludes that hypovitaminosis D, hypocalcemia and hyperphosphatemia is common in our pre-dialysis CKD patients and serum phosphorus raises more with reduction of GFR. 

Association between Serum 25-Hydroxyvitamin D Level and Cardiac Functions in Chronic kidney Disease Patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Saeed Abdelwahab Saeed ◽  
Ashraf Hassan Abd-elmobdy ◽  
Ahmed Abd-elaziz Mohammed Hassan
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Diastolic Function ◽  
Tissue Doppler Imaging ◽  
Serum Vitamin ◽  
Tissue Doppler ◽  
Doppler Imaging ◽  
Serum Vitamin D ◽  
Cardiac Functions

Abstract Background Chronic kidney disease (CKD) is a major public health problem worldwide and is associated with a considerable increase in morbidity and mortality, cardiovascular disease is most common cause of death among chronic kidney disease patients. There is an increasing interest in using vitamin D levels as a novel marker for CVD, because epidemiological data have shown a strong correlation between the risk of CVD and vitamin D deficiency. Objectives The aim of study was to determine the association between serum vitamin D level and cardiac functions assessed by tissue Doppler imaging in chronic kidney disease patients. Patients and Methods Our study conducted on 90 patients from outpatient clinic or inpatient department of national institute of nephrology and urology. All patients were subjected to full history, full clinical examination, laboratory investigations including: serum urea, serum albumin, complete blood picture, serum electrolytes (calcium and phosphorus), PTH, serum vitamin D, lipid profile and echocardiography and Tissue Doppler imaging. Conclusion Serum vitamin D is positively correlated with diastolic function among CKD patients, increased incidence of left ventricular hypertrophy in CKD patients especially with vitamin D deficiency, Tissue Doppler imaging is more accurate than echocardiography to estimate diastolic function.

scholarly journals Vitamin D Level in Predialysis Chronic Kidney Disease Patients Stage 3 to 5 and Predictors of its Deficiency

2021 ◽  
pp. 64-72
Author(s):  
Mohamed G. Mohamed ◽  
Hanaa I. Okda ◽  
Hossam A. Hodeib ◽  
Mostafa T. Gabr
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Parathyroid Hormone ◽  
Kidney Disease ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Ckd Stage ◽  
Significant Difference

Background: Vitamin D deficiency is commonly encountered in patients with chronic kidney disease (CKD) with or without undergoing dialysis. This study was conducted to assess vitamin D level in patients diagnosed with predialysis CKD stage 3 – 5, and to determine the predictors of its deficiency in such patients. Materials and Methods: This cross-sectional study included 75 patients who were divided into three equal groups of CKD-3, CKD-4 and CKD-5. All cases were subjected to detailed history taking, physical examination and measurement of estimated glomerular filtration rate (eGFR) according to Cockcroft-Gault formula. In addition, laboratory investigations included CBC, renal function tests, serum ferritin, intact parathyroid hormone (iPTH) and vitamin D level. Results: Patient demographics and other co-morbidities were comparable among the three groups. Serum vitamin D had mean values of 24.84, 20.52 and 11.24 ng/ml in patients with stages III, IV and V respectively, with significant difference between the three groups. Vitamin D deficiency was more common in CKD-5 cases. On the contrary, serum parathyroid hormone and ferritin were significantly higher levels, in patients with higher stages. There was statistically significant positive correlation of serumvitamin D with eGFR, Hb, calcium and albumin. On the other hand, serum vitamin D was negatively correlated with phosphate, PTH, urea andcreatinine. Conclusion: It is evident that higher stages of CKD are associated with more vitamin D deficiency.

scholarly journals Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease

2008 ◽  
Vol 74 (3) ◽  
pp. 389-390 ◽  
Author(s):  
Mervet Rouached ◽  
Sarra El Kadiri Boutchich ◽  
Assem Mohamed Al Rifai ◽  
Michèle Garabédian ◽  
Albert Fournier
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Calcium And Phosphorus
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