Déficits en dihydropyrimidine déshydrogénase et toxicité aux fluoropyrimidines

2010 ◽  
Vol 68 (1) ◽  
pp. 27-32
Author(s):  
M. Boisdron-Celle ◽  
A. Morel ◽  
E. Gamelin
Keyword(s):  
Dihydropyrimidine Deshydrogenase

Dihydropyrimidine déshydrogénase (DPD) : rythme et conséquences

2005 ◽  
Vol 53 (5) ◽  
pp. 261-264 ◽  
Author(s):  
M.-A. Barrat-Petit ◽  
C. Naulin-Ifi ◽  
P. Mahler ◽  
G. Milano
Keyword(s):  
Dihydropyrimidine Deshydrogenase

P.199 Tolérance des polychimiothérapies à base de 5-Fluorouracile et déficit d’activité de la dihydropyrimidine déshydrogénase

2009 ◽  
Vol 33 (3) ◽  
pp. A148
Author(s):  
C. Le Marchand-Soubiron ◽  
C. Le Guellec ◽  
A. Aubourg ◽  
K. Haguenoer ◽  
M. Boisdron-Celle ◽  
...  
Keyword(s):  
Dihydropyrimidine Deshydrogenase

Pharmacokinetic (PK) and tolerance profiles of oral tegafur/uracil (UFT) given as three versus two daily intakes

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 12013-12013
Author(s):  
M. C. Etienne-Grimaldi ◽  
E. François ◽  
N. Renée ◽  
J. M. Cardot ◽  
J. Y. Douillard ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Plasma Concentrations ◽  
Systemic Exposure ◽  
Grade 3 ◽  
Daily Intakes ◽  
Colorectal Cancer Patients ◽  
Ecog Ps ◽  
Digestive Toxicity ◽  
Dihydropyrimidine Deshydrogenase ◽  
Daily Time

12013 Background: This phase II randomized bioequivalence cross-over study compared the tolerance and PK profiles of oral UFT (tegafur-uracil) given as 3 daily intakes (tid, usual schedule) to that obtained with 2 daily intakes (bid). Methods: Twenty-one metastatic colorectal cancer patients were enrolled (16 men, 5 women ; mean age 64, extremes 42–79 ; ECOG PS ≤ 1). Tegafur-uracil (300 mg/m2/d) and leucovorin (90 mg/d) were given for 2 consecutive four-week cycles separated by one rest week. Patients were randomized for receiving 1st cycle either tid (arm A, 12 patients) or bid (arm B, 9 patients). For each schedule, PK was evaluated at steady state, over 24 h. Plasma concentrations of tegafur, uracil and fluorouracil (FU) were analyzed by HPLC. Results: Analysis of tolerance (digestive toxicity mainly, OMS grade) showed a tendency (p = 0.08) for a greater toxicity with the bid schedule (29% grade 2, 14% grade 3) relative to tid (24% grade 2 only). Although daily doses were similar, FU and uracil AUC0–24h were respectively 1.8 and 2.0-fold higher for bid as compared to tid (95% CI were 1.5–2.1 and 1.6–2.6, respectively, p < 0.0001). For tegafur, the 1.2-fold difference was of borderline significance (p = 0.057). The greater the FU AUC0–24h, the higher the toxicity intensity (p = 0.044). Analysis of systemic exposure with respect to daily time revealed that FU (p < 0.01) and uracil (p < 0.03) AUC corresponding to the morning intake were significantly higher than those corresponding to the afternoon or evening intakes, with AUC ratio as high as 1.6 for FU and 2.9 for uracil. Such a circadian influence was not observed for tegafur. Conclusions: To reach bioequivalence, bid tegafur-uracil administration will require lower doses than those given tid. The circadian variability observed for FU and uracil PK concords with that previously reported for dihydropyrimidine deshydrogenase activity. No significant financial relationships to disclose.

Toxic death-case after capecitabine + oxaliplatin (XELOX) administration: probable implication of dihydropyrimidine deshydrogenase deficiency

2005 ◽  
Vol 58 (2) ◽  
pp. 272-275 ◽  
Author(s):  
Joseph Ciccolini ◽  
Cedric Mercier ◽  
Laetitia Dahan ◽  
Alexandre Evrard ◽  
Jean-Christophe Boyer ◽  
...  
Keyword(s):  
Death Case ◽  
Dihydropyrimidine Deshydrogenase

Toxicité sévère à la capécitabine liée à un déficit enzymatique en dihydropyrimidine déshydrogénase (DPD)

2010 ◽  
Vol 34 (3) ◽  
pp. 218-223 ◽  
Author(s):  
S. Coursier ◽  
S. Martelet ◽  
A. Guillermet ◽  
J. Emptoz ◽  
C. Villier ◽  
...  
Keyword(s):  
Dihydropyrimidine Deshydrogenase

Toxic death-case after capecitabine administration: case report and implication of dihydropyrimidine deshydrogenase deficiency

2012 ◽  
Vol 19 (2) ◽  
pp. 132.1-132
Author(s):  
A.R. Rubio Salvador ◽  
J.I. Chacón López-Muñiz ◽  
L.J. López Gómez ◽  
J. Medina Martínez ◽  
J.M. Martínez Sesmero ◽  
...  
Keyword(s):  
Case Report ◽  
Death Case ◽  
Dihydropyrimidine Deshydrogenase

Variability of dihydropyrimidine deshydrogenase (DPD) activity in normal, inflammatory and tumoral tissues of colon and liver in humans

1998 ◽  
Vol 114 ◽  
pp. A604
Author(s):  
R. Guimbaud ◽  
S. Guichard ◽  
V. Bertrand ◽  
T. Aparicio ◽  
C. Terret ◽  
...  
Keyword(s):  
Dihydropyrimidine Deshydrogenase
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