scholarly journals Leptin and Ciliary Neurotrophic Factor Enhance the Formation of Gap Junctions Between Folliculostellate Cells in Castrated Male Rats.

2002 ◽  
Vol 65 (3) ◽  
pp. 269-278 ◽  
Author(s):  
Eisuke SAKUMA ◽  
Damon C. HERBERT ◽  
Tsuyoshi SOJI
Keyword(s):  
Gap Junctions ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Male Rats ◽  
Folliculostellate Cells

Cachectic effect of ciliary neurotrophic factor on innervated skeletal muscle

1996 ◽  
Vol 271 (5) ◽  
pp. R1422-R1428 ◽  
Author(s):  
D. Martin ◽  
E. Merkel ◽  
K. K. Tucker ◽  
J. L. McManaman ◽  
D. Albert ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Weight ◽  
Muscle Mass ◽  
Neurotrophic Factor ◽  
Skeletal Muscle Mass ◽  
Muscle Wasting ◽  
Body Weight Gain ◽  
Ciliary Neurotrophic Factor ◽  
Female Rats ◽  
Male Rats

Recombinant human ciliary neurotrophic factor (rh-CNTF) was reported to attenuate skeletal muscle wasting in rats after unilateral transection of the sciatic nerve (M. E. Helgren, S. P. Squinto, H. L. Davis, D. J. Parry, T. G. Bolton, C. S. Heck, Y. Zhu, G. D. Yancopoulos, R. M. Lindsay, and P. S. DiStefano. Cell 76: 493-504, 1994). Under the experimental conditions reported herein, the absolute masses of the denervated gastrocnemius and soleus muscles were not increased in mature or immature rats of either sex by treatment with rhCNTF. At the highest doses of rhCNTF (1 and 0.1 mg/kg), increases in the ratio of the masses of the denervated to the contralateral innervated gastrocnemius and soleus muscles could be attributed entirely to a muscle-wasting effect on the contralateral innervated muscle rather than any muscle-sparing effect on the denervated muscle. The muscle-wasting effects of rhCNTF were associated with reductions in body weight gain and reduced food intake. Pair-fed rats lost less body weight and skeletal muscle mass than rhCNTF-injected freely fed rats but experienced significantly greater loss of visceral mass. Male rats displayed greater loss of body weight and skeletal muscle mass than female rats. Recombinant inhibitors of the cachectic cytokines, tumor necrosis factor and interleukin-1, did not significantly alter the wasting effects of rhCNTF. These findings demonstrate that, in contrast to its well-characterized trophic effects on cells of the nervous system, rhCNTF causes atrophy of skeletal muscle by mechanisms involving both anorexia and cachexia based on the results of pair-feeding experiments.

Preventing blindness in retinal disease: ciliary neurotrophic factor intraocular implants

2007 ◽  
Vol 42 (3) ◽  
pp. 399-402 ◽  
Author(s):  
Ian M. MacDonald ◽  
Yves Sauvé ◽  
Paul A. Sieving
Keyword(s):  
Neurotrophic Factor ◽  
Retinal Disease ◽  
Ciliary Neurotrophic Factor

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

Nature ◽  
1990 ◽  
Vol 345 (6274) ◽  
pp. 440-441 ◽  
Author(s):  
Michael Sendtner ◽  
Georg W. Kreutzberg ◽  
Hans Thoenen
Keyword(s):  
Motor Neurons ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor

Selective upregulation of RB3/stathmin4 by ciliary neurotrophic factor following optic nerve axotomy

2005 ◽  
Vol 1061 (2) ◽  
pp. 97-106 ◽  
Author(s):  
Toru Nakazawa ◽  
Hiroshi Morii ◽  
Makoto Tamai ◽  
Nozomu Mori
Keyword(s):  
Optic Nerve ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor

Ciliary neurotrophic factor enhances nicotinic synaptic transmission in sympathetic neurons

2009 ◽  
pp. NA-NA ◽  
Author(s):  
Qiang Nai ◽  
Xiaoyun Wang ◽  
Ying Jin ◽  
Dongbin Sun ◽  
Man Li ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Neurotrophic Factor ◽  
Sympathetic Neurons ◽  
Ciliary Neurotrophic Factor
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