CARBOHYDRATE METABOLISM IN KLINEFELTER'S SYNDROME

1966 ◽  
Vol 35 (2) ◽  
pp. 169-172 ◽  
Author(s):  
I. M. D. JACKSON ◽  
K. D. BUCHANAN ◽  
M. T. McKIDDIE ◽  
C. R. M. PRENTICE
Keyword(s):  
Carbohydrate Metabolism ◽  
Insulin Response ◽  
Oral Glucose ◽  
Klinefelter’S Syndrome ◽  
Oral Glucose Tolerance ◽  
Glucose Load ◽  
Klinefelter's Syndrome ◽  
Glucose Tolerance Curve ◽  
Plasma Insulin Levels ◽  
Tolerance Curve

SUMMARY Carbohydrate metabolism has been investigated in eight patients with Klinefelter's syndrome. Seven of the eight had a normal oral glucose tolerance curve; one patient had slightly impaired tolerance. Plasma insulin levels were measured in response to the glucose load and were normal in six and slightly abnormal in two patients; one of the latter had an early increased and the other a delayed insulin response. No definite conclusions are reached regarding the possibility of a significant association between Klinefelter's syndrome and diabetes mellitus.

Evidence that the oral glucose-tolerance test does not provide a uniform stimulus to pancreatic islets in pregnancy.

1989 ◽  
Vol 35 (7) ◽  
pp. 1482-1485 ◽  
Author(s):  
E A de Leacy ◽  
D M Cowley
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Pancreatic Islets ◽  
Glucose Tolerance Test ◽  
Insulin Response ◽  
Tolerance Test ◽  
Glucose Absorption ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Glucose Load

Abstract Fifty consecutive pregnant patients referred for a glucose-tolerance test were classified on the basis of increasing (n = 20) or decreasing (n = 28) hematocrit after an oral 75-g glucose load. (The hematocrit did not change in the other two patients.) Patients with increasing hematocrit, a response previously seen in patients with the dumping syndrome, showed significantly flatter increases in glucose concentrations in plasma after the load. The mean decrease in the concentration of phosphate in plasma, measured as an index of glucose uptake by cells, was significantly less (P less than 0.05) 2 h after the load in the group with flatter glucose responses, suggesting that the flat response is ascribable to poor glucose absorption rather than to an exaggerated insulin response. These results indicate that the oral glucose-tolerance test stresses the pancreatic islets differently in different pregnant subjects, owing to individual variations in the gastrointestinal handling of the glucose load. Consequently, patients may give a "normal" result who might otherwise become hyperglycemic after normal meals. We suggest that alternative screening procedures be investigated to assess pregnant patients postprandially.

Efficacy of cryohypophysectomy in the treatment of acromegaly

1977 ◽  
Vol 46 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Michael V. DiTullio ◽  
Robert W. Rand
Keyword(s):  
Growth Hormone ◽  
Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Serum Growth Hormone ◽  
Beneficial Result ◽  
Content Type ◽  
Glucose Tolerance Curve ◽  
Tolerance Curve ◽  
Suprasellar Extension

✓ Between 1963 and 1974, 54 patients with acromegaly (28 men and 26 women) ranging in age from 23 to 61 years were evaluated. Each patient underwent thorough preoperative neurological, roentgenographic, and endocrinological surveys; most demonstrated mild-to-severe abnormalities in growth hormone immunoassay and oral glucose tolerance. Of those who underwent stereotaxic cryohypophysectomy, approximately 80% were considered to have a beneficial result. The efficacy of this form of therapy was judged on the basis of: 1) significant overall clinical improvement and regression of acromegalic features; 2) improvement in the glucose tolerance curve; and 3) a fall of serum growth hormone below 10 ng/ml. Complications including rhinorrhea, meningitis, and hemorrhage occurred in only a small number of cases. A comparison is made between this technique and others, including craniotomy, radiotherapy, and transnasal transsphenoidal hypophysectomy. The efficacy, low morbidity, and the ease with which the procedure may be performed make this our treatment of choice when dealing with growth-hormone-producing pituitary adenomas with no suprasellar extension.

A STUDY OF THE “FLAT” ORAL GLUCOSE TOLERANCE CURVE AND ITS RELATION TO RATE OF EMPTYING OF THE STOMACH

1956 ◽  
Vol 231 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Charles E. Test ◽  
Russell L. Nichols ◽  
Richard L. Landau ◽  
Henry T. Ricketts ◽  
Ruth Loughead
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Glucose Tolerance Curve ◽  
Tolerance Curve

Relationship between insulin response to oral glucose load and creatinine clearance

Diabetes ◽  
1975 ◽  
Vol 24 (12) ◽  
pp. 1066-1071 ◽  
Author(s):  
K. Yasuda ◽  
T. Sato ◽  
T. Furuyama ◽  
K. Yashinaga
Keyword(s):  
Creatinine Clearance ◽  
Insulin Response ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

Enhanced Insulin Response to Oral Glucose Load in Patients with Angina Pectoris Associated with ST Segment Elevation in the Absence of Epicardial Coronary Arterial Obstruction

Angiology ◽  
1998 ◽  
Vol 49 (9) ◽  
pp. 815-826 ◽  
Author(s):  
Shigeo Takata ◽  
Atsuhiro Shimakura ◽  
Satoru Sakagami ◽  
Yukio Nakamura ◽  
Hitoshi Ohkuwa ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Insulin Response ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
St Segment Elevation ◽  
St Segment
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