Histological and biological evolution of human premalignant breast disease.

2001 ◽  
pp. 47-61 ◽  
Author(s):  
D C Allred ◽  
S K Mohsin ◽  
S A Fuqua
Keyword(s):  
Biological Evolution ◽  
Breast Disease ◽  
Premalignant Lesions ◽  
Breast Cancers ◽  
Benign Lesions ◽  
Evolutionary Pathway ◽  
Scientific Investigations ◽  
Genetic Mechanisms ◽  
The Many

Most human invasive breast cancers (IBCs) appear to develop over long periods of time from certain pre-existing benign lesions. Of the many types of benign lesions in the human breast, only a few appear to have significant premalignant potential. The best characterized of these include atypical hyperplasias and in situ carcinomas and both categories are probably well on along the evolutionary pathway to IBC. Very little is known about earlier premalignant alterations. All types of premalignant breast lesions are relatively common but only a small proportion appear to progress to IBC. They are currently defined by their histological features and their prognosis is imprecisely estimated from indirect epidemiological evidence. Although lesions within specific categories look alike, they must possess underlying biological differences causing some to remain stable and others to progress. Recent studies suggest that they evolve by highly diverse genetic mechanisms and research into these altered pathways may identify specific early defects that can be targeted to prevent premalignant lesions from developing or becoming cancerous. It is far more rational to think that breast cancer can be prevented than cured once it has developed fully. This review discusses histological models of human premalignant breast disease that provide the framework for scientific investigations into the biological alterations behind them and examples of specific biological alterations that appear to be particularly important.

scholarly journals Assessment of the Accuracy of the Gail Model in Women With Atypical Hyperplasia

2008 ◽  
Vol 26 (33) ◽  
pp. 5374-5379 ◽  
Author(s):  
V. Shane Pankratz ◽  
Lynn C. Hartmann ◽  
Amy C. Degnim ◽  
Robert A. Vierkant ◽  
Karthik Ghosh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Health Care Professionals ◽  
Breast Disease ◽  
Develop Breast Cancer ◽  
Atypical Hyperplasia ◽  
Individual Risk ◽  
Breast Cancers ◽  
Gail Model ◽  
Patient Counseling

Purpose An accurate estimate of a woman's breast cancer risk is essential for optimal patient counseling and management. Women with biopsy-confirmed atypical hyperplasia of the breast (atypia) are at high risk for breast cancer. The Gail model is widely used in these women, but has not been validated in them. Patients and Methods Women with atypia were identified from the Mayo Benign Breast Disease (BBD) cohort (1967 to 1991). Their risk factors for breast cancer were obtained, and the Gail model was used to predict 5-year–and follow-up–specific risks for each woman. The predicted and observed numbers of breast cancers were compared, and the concordance between individual risk levels and outcomes was computed. Results Of the 9,376 women in the BBD cohort, 331 women had atypia (3.5%). At a mean follow-up of 13.7 years, 58 of 331 (17.5%) patients had developed invasive breast cancer, 1.66 times more than the 34.9 predicted by the Gail model (95% CI, 1.29 to 2.15; P < .001). For individual women, the concordance between predicted and observed outcomes was low, with a concordance statistic of 0.50 (95% CI, 0.44 to 0.55). Conclusion The Gail model significantly underestimates the risk of breast cancer in women with atypia. Its ability to discriminate women with atypia into those who did and did not develop breast cancer is limited. Health care professionals should be cautious when using the Gail model to counsel individual patients with atypia.

scholarly journals A general Cluster data and global MHD simulation comparison

2008 ◽  
Vol 26 (11) ◽  
pp. 3411-3428 ◽  
Author(s):  
P. Daum ◽  
M. H. Denton ◽  
J. A. Wild ◽  
M. G. G. T. Taylor ◽  
J. Šafránková ◽  
...  
Keyword(s):  
Large Scale ◽  
Numerical Models ◽  
Mhd Simulation ◽  
Global Context ◽  
Cluster Data ◽  
Verification Methods ◽  
Modelling Studies ◽  
Global Mhd Simulation ◽  
The Many

Abstract. Among the many challenges facing the space weather modelling community today, is the need for validation and verification methods of the numerical models available describing the complex nonlinear Sun-Earth system. Magnetohydrodynamic (MHD) models represent the latest numerical models of this environment and have the unique ability to span the enormous distances present in the magnetosphere, from several hundred kilometres to several thousand kilometres above the Earth's surface. This makes it especially difficult to develop verification and validation methods which posses the same range spans as the models. In this paper we present a first general large-scale comparison between four years (2001–2004) worth of in situ Cluster plasma observations and the corresponding simulated predictions from the coupled Block-Adaptive-Tree-Solarwind-Roe-Upwind-Scheme (BATS-R-US) MHD code. The comparison between the in situ measurements and the model predictions reveals that by systematically constraining the MHD model inflow boundary conditions a good correlation between the in situ observations and the modeled data can be found. These results have an implication for modelling studies addressing also smaller scale features of the magnetosphere. The global MHD simulation can therefore be used to place localised satellite and/or ground-based observations into a global context and fill the gaps left by measurements.

scholarly journals Observation of microstructure change during freeze-drying by in-situ X-ray Computed Tomography

2018 ◽  
Author(s):  
Kyuya Nakagawa ◽  
Shinri Tamiya ◽  
Shu Sakamoto ◽  
Gabsoo Do ◽  
Shinji Kono ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Freeze Drying ◽  
Glassy State ◽  
Structural Deformation ◽  
Microstructure Formation ◽  
Microstructure Change ◽  
X Ray ◽  
X Ray Computed ◽  
The Many

X-ray computed tomography technique was used to observe microstructure formation during freeze-drying. A specially designed vacuum freeze-drying stage was equipped at the X-ray CT stage, and the frozen and dried microstructures of dextrin solutions were successfully observed. It was confirmed that the many parts of the pore microstructures formed as a replica of the original ice microstructures, whereas some parts formed as a consequence of the dehydration dependent on the relaxation level of the glassy phases, suggesting that the post-freezing annealing is advantageous for avoiding quality loss that relates to the structural deformation of glassy matters. Keywords: freeze-drying; X-ray CT; ice microstructure; glassy state

scholarly journals Advances in Polyhydroxyalkanoate Nanocarriers for Effective Drug Delivery: An Overview and Challenges

Nanomaterials ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 175
Author(s):  
Priyanka Prakash ◽  
Wing-Hin Lee ◽  
Ching-Yee Loo ◽  
Hau Seung Jeremy Wong ◽  
Thaigarajan Parumasivam
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
In Situ Polymerization ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Production Costs ◽  
Natural Polymers ◽  
High Production ◽  
The Many

Polyhydroxyalkanoates (PHAs) are natural polymers produced under specific conditions by certain organisms, primarily bacteria, as a source of energy. These up-and-coming bioplastics are an undeniable asset in enhancing the effectiveness of drug delivery systems, which demand characteristics like non-immunogenicity, a sustained and controlled drug release, targeted delivery, as well as a high drug loading capacity. Given their biocompatibility, biodegradability, modifiability, and compatibility with hydrophobic drugs, PHAs often provide a superior alternative to free drug therapy or treatments using other polymeric nanocarriers. The many formulation methods of existing PHA nanocarriers, such as emulsion solvent evaporation, nanoprecipitation, dialysis, and in situ polymerization, are explained in this review. Due to their flexibility that allows for a vessel tailormade to its intended application, PHA nanocarriers have found their place in diverse therapy options like anticancer and anti-infective treatments, which are among the applications of PHA nanocarriers discussed in this article. Despite their many positive attributes, the advancement of PHA nanocarriers to clinical trials of drug delivery applications has been stunted due to the polymers’ natural hydrophobicity, controversial production materials, and high production costs, among others. These challenges are explored in this review, alongside their existing solutions and alternatives.

scholarly journals Probing Multiscale Disorder in Pyrochlore and Related Complex Oxides in the Transmission Electron Microscope: A Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Jenna L. Wardini ◽  
Hasti Vahidi ◽  
Huiming Guo ◽  
William J. Bowman
Keyword(s):  
Complex Oxides ◽  
Atomic Scale ◽  
High Dimensional ◽  
Detection Systems ◽  
Spatially Resolved ◽  
Chemical Ordering ◽  
Transmission Electron ◽  
The Many ◽  
High Dimensional Datasets

Transmission electron microscopy (TEM), and its counterpart, scanning TEM (STEM), are powerful materials characterization tools capable of probing crystal structure, composition, charge distribution, electronic structure, and bonding down to the atomic scale. Recent (S)TEM instrumentation developments such as electron beam aberration-correction as well as faster and more efficient signal detection systems have given rise to new and more powerful experimental methods, some of which (e.g., 4D-STEM, spectrum-imaging, in situ/operando (S)TEM)) facilitate the capture of high-dimensional datasets that contain spatially-resolved structural, spectroscopic, time- and/or stimulus-dependent information across the sub-angstrom to several micrometer length scale. Thus, through the variety of analysis methods available in the modern (S)TEM and its continual development towards high-dimensional data capture, it is well-suited to the challenge of characterizing isometric mixed-metal oxides such as pyrochlores, fluorites, and other complex oxides that reside on a continuum of chemical and spatial ordering. In this review, we present a suite of imaging and diffraction (S)TEM techniques that are uniquely suited to probe the many types, length-scales, and degrees of disorder in complex oxides, with a focus on disorder common to pyrochlores, fluorites and the expansive library of intermediate structures they may adopt. The application of these techniques to various complex oxides will be reviewed to demonstrate their capabilities and limitations in resolving the continuum of structural and chemical ordering in these systems.

scholarly journals Tehnika splenektomije

2002 ◽  
Vol 49 (3) ◽  
pp. 45-50 ◽  
Author(s):  
Radoje Colovic
Keyword(s):  
Operative Technique ◽  
Splenic Artery ◽  
Benign Lesions ◽  
Operative Complications ◽  
Short Gastric Vessels ◽  
Gastrosplenic Ligament ◽  
Accessory Spleens

Splenectomy has been performed in trauma in a number of benign lesions of the spleen and in a certain haematological diseases. When performed for trauma a luxation technique of splenectomy is applied since it allows quick haemostasis. When performed in other indications, the spleen is usually enlarged. In those patients "splenectomy in situ" is recommended. That means, first, division of the short gastric vessels and gastrosplenic ligament, second, ligation of the splenic artery and finally division of the hilar vessels after which the spleen may be simply removed. Details of operative technique, management of accessory spleens and prevention of operative complications are described.

scholarly journals Glans Resurfacing in Carcinoma in situ of the Penis: A Case Report

2020 ◽  
pp. 1-5
Author(s):  
Raquel Catarino ◽  
André Cardoso ◽  
Carlos Ferreira ◽  
Diogo Pereira ◽  
Tiago Correia ◽  
...  
Keyword(s):  
Case Report ◽  
Carcinoma In Situ ◽  
Penile Cancer ◽  
Treatment Options ◽  
Surgical Techniques ◽  
Disease Recurrence ◽  
Premalignant Lesions ◽  
Surgical Approaches ◽  
Aesthetic Result

Aims: Penile cancer is an uncommon malignancy in Western countries. There are known premalignant lesions that can progress to invasive penile cancer, namely carcinoma in situ (CIS) of the glans. Treatment options for this disease include topical chemotherapy and laser ablation, but the published literature demonstrates limited efficacy for these approaches. Surgical techniques with penile-preserving approaches are performed with the goal of removing the entire tumor and preserving as much of penis as possible. There are no large, randomized studies comparing treatment options for these lesions, and reports concerning the surgical approaches are scarce. Presentation of Case: In this study, we present a case report of a patient with CIS of the glans penis surgically treated with glans resurfacing. Discussion and Conclusions: There were no complications during follow-up, and after 20 months, the patient has no evidence of disease recurrence, has preserved urinary and erectile functions and is currently satisfied with the cosmetic appearance. CIS treatment with glans resurfacing allows the maintenance penile length and function with a good aesthetic result without compromising oncologic control. This approach also allows an accurate staging of the disease and assessment of the treatment efficacy.

scholarly journals Lower HER-2/chromosome enumeration probe 17 ratio in cytologic HER-2 fluorescence in situ hybridization for breast cancers

Cancer ◽  
2008 ◽  
Vol 114 (2) ◽  
pp. 134-140 ◽  
Author(s):  
Hitoshi Itoh ◽  
Yoko Miyajima ◽  
Shinobu Umemura ◽  
Robert Y. Osamura
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Breast Cancers ◽  
Her 2
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