Role of regulatory peptides in the control of breast cancer cell growth and function

1994 ◽  
Vol 1 (3) ◽  
pp. 41-70 ◽  
Author(s):  
M P Schrey ◽  
K V Patel
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Regulatory Peptides ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
And Function

scholarly journals Role of ALDH1A1 and HTRA2 expression in CCL2/CCR2-mediated breast cancer cell growth and invasion

Biology Open ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. bio040873 ◽  
Author(s):  
Qingting Hu ◽  
Megan Myers ◽  
Wei Fang ◽  
Min Yao ◽  
Gage Brummer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals RASSF1A Suppresses Estrogen-Dependent Breast Cancer Cell Growth through Inhibition of the Yes-Associated Protein 1 (YAP1), Inhibition of the Forkhead Box Protein M1 (FOXM1), and Activation of Forkhead Box Transcription Factor 3A (FOXO3A)

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2689
Author(s):  
Sven Roßwag ◽  
Gitta Thiede ◽  
Jonathan P. Sleeman ◽  
Sonja Thaler
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Forkhead Box ◽  
Cancer Initiation ◽  
And Function

The estrogen receptor alpha (ERα) is expressed by the majority of breast cancers and plays an important role in breast cancer development and tumor outgrowth. Although ERα is well known to be a specific and efficient therapeutic target, the molecular mechanisms that are responsible for the control of ERα expression and function in the context of breast cancer initiation and progression are complex and not completely elucidated. In previous work, we have demonstrated that the tumor suppressor RASSF1A inhibits ERα expression and function in ERα-positive breast cancer cells through an AKT-dependent mechanism. Transcriptional activators such as forkhead box protein M1 (FOXM1) and forkhead transcription factor 3A (FOXO3A) and signaling pathways such as the Hippo pathway are also known to modulate ERα expression and activity. Here we report that RASSF1A acts as an inhibitor of ERα-driven breast cancer cell growth through a complex, hierarchically organized network that initially involves suppression of the Hippo effector Yes-associated protein 1 (YAP1), which is followed by inhibition of AKT1 activity, increased FOXO3A activity as well as a blockade of FOXM1 and ERα expression. Together our findings provide important new mechanistic insights into how the loss of RASSF1A contributes to ERα+ breast cancer initiation and progression.

scholarly journals Biphasic Regulation of Breast Cancer Cell Growth by Progesterone: Role of the Cyclin-Dependent Kinase Inhibitors, p21 and p27Kip1

1997 ◽  
Vol 11 (11) ◽  
pp. 1593-1607 ◽  
Author(s):  
Steve D. Groshong ◽  
Gareth I. Owen ◽  
Bryn Grimison ◽  
Irene E. Schauer ◽  
Maria C. Todd ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Kinase Inhibitors ◽  
Cyclin Dependent Kinase ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Role of Androgens on MCF-7 Breast Cancer Cell Growth and on the Inhibitory Effect of Letrozole

2006 ◽  
Vol 66 (15) ◽  
pp. 7775-7782 ◽  
Author(s):  
Luciana F. Macedo ◽  
Zhiyong Guo ◽  
Syreeta L. Tilghman ◽  
Gauri J. Sabnis ◽  
Yun Qiu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Inhibitory Effect ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Mcf 7

scholarly journals Inhibitory effect of adiponectin on breast cancer cell growth: evidences of the crucial role of ERα expression

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Loredana Mauro ◽  
Michele Pellegrino ◽  
Francesca De Amicis ◽  
Cinzia Giordano ◽  
Sebastiano Andò
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Crucial Role ◽  
Inhibitory Effect ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Globular Adiponectin Inhibits Breast Cancer Cell Growth through Modulation of Inflammasome Activation: Critical Role of Sestrin2 and AMPK Signaling

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 613 ◽  
Author(s):  
Duc-Vinh Pham ◽  
Pawan Kumar Raut ◽  
Mahesh Pandit ◽  
Jae-Hoon Chang ◽  
Nikita Katila ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cells ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Globular Adiponectin

Adiponectin, an adipokine predominantly derived from adipose tissue, exhibits potent antitumor properties in breast cancer cells. However, its mechanisms of action remain elusive. Inflammasomes—intracellular multimeric protein complexes—modulate cancer cell growth in a complicated manner, as well as playing a role in the innate immune system. Herein, we examined the potential role of inflammasomes in the antitumor activity of adiponectin and found that globular adiponectin (gAcrp) significantly suppressed inflammasomes activation in breast cancer cells both in vitro and in vivo conditions, as determined by decreased expression of inflammasomes components, including NOD-like receptor pyrin domain-containing protein 3 (NLRP3) and the apoptosis-associated speck-like protein containing a CARD (ASC), and inhibition of interleukin-1β and caspase-1 activation. Treatment with pharmacological inhibitors of inflammasomes caused decrease in cell viability, apoptosis induction, and G0/G1 cell cycle arrest, suggesting that inflammasomes activation is implicated in the growth of breast cancer cells. In addition, treatment with gAcrp generated essentially similar results to those of inflammasomes inhibitors, further indicating that suppression of breast cancer cell growth by gAcrp is mediated via modulation of inflammasomes. Mechanistically, gAcrp suppressed inflammasomes activation through sestrin2 (SESN2) induction, liver kinase B1 (LKB-1)-dependent AMP-activated protein kinase (AMPK) phosphorylation, and alleviation of endoplasmic reticulum (ER) stress. Taken together, these results demonstrate that gAcrp inhibits growth of breast cancer cells by suppressing inflammasomes activation, at least in part, via SESN2 induction and AMPK activation-dependent mechanisms.

Abstract 3794: The role of LMTK3 in breast cancer cell growth and invasion.

2013 ◽  
Author(s):  
Yichen Xu ◽  
Aleksandra Filipovic ◽  
Hua Zhang ◽  
Lei Cheng Lit ◽  
Ylenia Lombardo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Knockdown of Mgat5 Inhibits Breast Cancer Cell Growth with Activation of CD4+ T Cells and Macrophages

2008 ◽  
Vol 180 (5) ◽  
pp. 3158-3165 ◽  
Author(s):  
Dongqing Li ◽  
Yanmei Li ◽  
Xianglei Wu ◽  
Qiao Li ◽  
Jing Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cd4 T Cells ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth
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