scholarly journals Radiation-induced hypopituitarism

2009 ◽  
Vol 16 (3) ◽  
pp. 733-772 ◽  
Author(s):  
Alberto Fernandez ◽  
Michael Brada ◽  
Lina Zabuliene ◽  
Niki Karavitaki ◽  
John A H Wass
Keyword(s):  
At Risk ◽  
Survival Rates ◽  
Whole Body ◽  
Individual Risk ◽  
Endocrine Disorders ◽  
Radiation Induced ◽  
Radiation Treatments ◽  
The Individual ◽  
Expanding Population ◽  
The Impact

The hypothalamic–pituitary unit is a particularly radiosensitive region in the central nervous system. As a consequence, hypopituitarism commonly develops after radiation treatments for sellar and parasellar neoplasms, extrasellar brain tumours, head and neck tumours, and following whole body irradiation for systemic malignancies. Increasing tumour-related survival rates provide an expanding population at risk of developing hypopituitarism. In this population, long-term monitoring tailored to the individual risk profile is required to avoid the sequelae of untreated pituitary hormonal deficiencies and resultant decrease in the quality of life. This review analyses the pathogenesis, prevalence and consequences of radiation-induced hypopituitarism (RIH) in diverse subgroups at risk. Also discussed is the impact of modern radiotherapy techniques in the prevalence of RIH, the spectrum of endocrine disorders and radiation-induced brain conditions that also occur in patients with RIH.

Homozygous and double heterozygous Factor V Leiden and Factor II G20210A genotypes predispose infants to thromboembolism but are not associated with an increase of foetal loss

2003 ◽  
Vol 90 (10) ◽  
pp. 628-635 ◽  
Author(s):  
Patrick Hundsdoerfer ◽  
Barbara Vetter ◽  
Brigitte Stöver ◽  
Christian Bassir ◽  
Tristess Scholz ◽  
...  
Keyword(s):  
Factor V Leiden ◽  
Individual Risk ◽  
Factor V ◽  
Thromboembolic Events ◽  
Foetal Loss ◽  
Asymptomatic Children ◽  
Factor Ii ◽  
The Individual ◽  
The Impact

SummaryProspective and controlled data about the individual risk profile in asymptomatic children with homozygous or double heterozygous risk genotypes for Factor V Leiden (FVL) and factor II (FII) G20210A are currently unavailable. The systematic and prospective observational study presented here was designed to determine the impact of the homozygous and double heterozygous FVL and FII G20210A genotypes on the prenatal and postnatal risk profiles of affected children. Risk infants and heterozygous controls were identified by screening of 85,304 neonates. Follow-up included the comparison of prenatal and postnatal development, ultrasonography of brain and kidneys, and a panel of independent determinants of thrombophilia. The numbers of identified or expected FVL homozygotes and double heterozygotes did not differ significantly (FVL: 116 ver-sus 91, p=0.08; FVL/FII: 94 versus 76, p=0.17), indicating the absence of a prenatal disadvantage. A prenatal advantage was suggested in FII homozygotes, whose identified number far exceeded the expected (19 versus 4, p=0.002). Clinical and/or imaging abnormalities indicated spontaneous thromboembolic events in 4 of 129 risk infants (3%) but in none of the 178 controls (p=0.02). Physical and neurological development was normal in both groups during the first 2 years of life. The risk genotypes appear to confer a significant predisposition for spontaneous thromboembolic events in infancy without impeding development within the first two years of life. Foetal risk genotypes do not cause an increased foetal loss rate. Moreover, homozygous FII G20210A appears to be associated with a prenatal advantage.

WHAT ANATOMIC FEATURES GOVERN PERSONAL LONG-TERM HEALTH RISKS FROM BREAST CANCER RADIOTHERAPY?

2019 ◽  
Vol 186 (2-3) ◽  
pp. 381-385
Author(s):  
Pavel Kundrát ◽  
Cristoforo Simonetto ◽  
Markus Eidemüller ◽  
Julia Remmele ◽  
Hannes Rennau ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Health Risks ◽  
Individual Risk ◽  
Breast Cancer Patients ◽  
Cancer Radiotherapy ◽  
Breast Cancer Radiotherapy ◽  
Radiation Induced ◽  
Risk Variability ◽  
The Individual

Abstract Breast cancer radiotherapy may in the long term lead to radiation-induced secondary cancer or heart disease. These health risks hugely vary among patients, partially due to anatomy-driven differences in doses deposited to the heart, ipsilateral lung and contralateral breast. We identify four anatomic features that largely cover these dosimetric variations to enable personalized risk estimates. For three exemplary, very different risk scenarios, the given parameter set reproduces 63–74% of the individual risk variability for left-sided breast cancer patients. These anatomic features will be used in the PASSOS software to support decision processes in breast-cancer therapy.

There Is No “I” in Team but There Is in Innovation: How Individual Attributes Impact Team Ideation and Selection Practices

2021 ◽  
Author(s):  
Aoran Peng ◽  
Sam Hunter ◽  
Scarlett R. Miller
Keyword(s):  
Positive Impact ◽  
Preliminary Evidence ◽  
Design Stage ◽  
Individual Risk ◽  
Team Composition ◽  
Concept Generation ◽  
Team Members ◽  
The Individual ◽  
The Impact

Abstract While teaming is a vital component of engineering, it is important to remember that there is no team without individuals and individual behavior can drive team outputs. One of these individual factors that may manifest itself at the team level is individual risk-taking attitudes, which can be impacted by personality and preferences for creativity. However, a gap exists in research on the impact of the team composition in these factors on creative outputs, as previous research has found that team composition plays a key role in team performance. The current work was developed to examine how the elevation and diversity of team personality and preferences for creativity impact the novelty and quality of ideas generated and selected by the team through a simulation study of 60,831 simulated teams. The results of this study show that the novelty and quality of ideas generated and selected can be predicted by the elevation and diversity of the simulated teams’ personality and PCS factors. In addition, it was found that the impact of the individual elevation and diversity factors can vary depending on the ideation trait (novelty and quality) and design stage (concept generation and selection). However, there was one variable that had a consistent positive impact on team behavior — the elevation of the Creative Confidence of the Simulated Team Members. These findings provide preliminary evidence on how individual attributes manifest themselves at the team level to impact team ideation and selection performances.

Style Over Substance Reconsidered: Intrusive Intervention and At-Risk Students with Learning Disabilities

2002 ◽  
Vol 22 (2) ◽  
pp. 66-77 ◽  
Author(s):  
Robert Abelman ◽  
Anthony Molina
Keyword(s):  
At Risk ◽  
Learning Disabilities ◽  
Student Performance ◽  
At Risk Students ◽  
Retention Rates ◽  
Students With Learning Disabilities ◽  
Grade Point ◽  
Probationary Students ◽  
The Individual ◽  
The Impact

In two recent publications, we reported that the academic intervention process, not the specific intervention content, was responsible for a short-and long-term influx in at-risk student performance (grade-point average) and persistence (retention). All at-risk students who participated in the most intrusive of three interventions had higher cumulative grade-point averages and retention rates than those who received less intrusive interventions. In this post hoc analysis, we looked at probationary students with learning disabilities and found that they are only responsive to the individual attention and personalized accommodation provided under a highly intrusive model, and the impact is temporary.

Temporal complexity in clinical manifestations of lung disease

2011 ◽  
Vol 110 (6) ◽  
pp. 1723-1731 ◽  
Author(s):  
Urs Frey ◽  
Geoffrey Maksym ◽  
Béla Suki
Keyword(s):  
Lung Function ◽  
Statistical Physics ◽  
Clinical Manifestations ◽  
Individual Risk ◽  
Fluctuation Analysis ◽  
Temporal Complexity ◽  
History Of ◽  
The Individual ◽  
The Impact ◽  
Insight Into

In this review, we summarize results of recent research on the temporal variability of lung function, symptoms, and inflammatory biomarkers. Specifically, we demonstrate how fluctuation analysis borrowed from statistical physics can be used to gain insight into neurorespiratory control and complex chronic dynamic diseases such as asthma viewed as a system of interacting components (e.g., inflammatory, immunological, and mechanical). Fluctuation analysis tools are based on quantifying the distribution and the short- and long-term temporal history of tidal breathing and lung function parameters to assess neurorespiratory control and monitor chronic disease. The latter includes the assessment of severity and disease control, the impact of treatment and environmental triggers, the temporal characterization of disease phenotypes, and the individual risk of exacerbation. While in many cases specific mechanistic insight into the fluctuations still awaits further research, appropriate analyses of the fluctuations already impact on clinical science and practice.

scholarly journals Familial Pancreatic Cancer: The Case for Prophylactic Pancreatectomy in Lieu of Serial Screening and Shared Decision Making

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Mazen E. Iskandar ◽  
Michael G. Wayne ◽  
Justin G. Steele ◽  
Avram M. Cooperman
Keyword(s):  
Pancreatic Cancer ◽  
At Risk ◽  
Clinical Course ◽  
Total Pancreatectomy ◽  
Intraepithelial Neoplasia ◽  
Individual Risk ◽  
Familial Pancreatic Cancer ◽  
History Of ◽  
The Individual ◽  
Duct Stricture

At-risk family members with familial pancreatic cancer (FCaP) face uncertainty regarding the individual risk of developing pancreatic cancer (CaP) and whether to choose serial screening or prophylactic pancreatectomy to avoid CaP. We treated 2 at-risk siblings with a history of FCaP, congenital hepatic fibrosis (CHF), and jaundice secondary to a bile duct stricture. In one, a pancreaticoduodenal resection was done and in the second a total pancreatectomy. Malignancy was not present, but extensive pancreatic intraepithelial neoplasia (PanIn) 2 was present throughout both pancreata. The clinical course and literature review are presented along with the previously unreported association of CHF and CaP.

Alleviating Poverty in Malta: Changing Minds through Education

2019 ◽  
Vol 3 (1) ◽  
pp. 20-41
Author(s):  
Theresa Demanuele Montebello
Keyword(s):  
At Risk ◽  
Inclusive Education ◽  
Holistic Approach ◽  
Building Blocks ◽  
Ripple Effect ◽  
Financial Capability ◽  
Key Skills ◽  
The Individual ◽  
The Right ◽  
The Impact

Education plays an important role in minimizing the risk of a person falling into poverty. Studies have shown that persons who pursue an education to post-secondary and tertiary level are considered to be less at risk of poverty. Studies also show that the impact of education and the risk of poverty may also be generational. Individuals born in families with a lower educational level are more likely to be at risk of poverty. Research has shown that children who experience poverty very early in life may tend to have issues with achieving a complete education. This may have a ripple effect since education effects employability; that, in turn, plays an important role to address the importance of improving the financial capability of the individual and his family. This research aims to indicate strategies that may be drawn up in order to address the important role of education in eradicating poverty. A holistic approach which offers the right content, structure, and facilities is important in order to guarantee a sound basis on which more educational building blocks may be built by the individual during the educational path that the person decides to follow. Changing minds of professionals involved in planning and devising educational reforms and strategies, together with providing the most adequate support for inclusive education, key skills tutoring, and mentoring, will ensure more success stories. All these strategies will concurrently help in different ways to address the issue of financial capability of an individual and his family, and thus alleviate poverty.

scholarly journals Consequences of Job Insecurity on the Psychological and Physical Health of Greek Civil Servants

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Dimitra Nella ◽  
Efharis Panagopoulou ◽  
Nikiforos Galanis ◽  
Anthony Montgomery ◽  
Alexis Benos
Keyword(s):  
At Risk ◽  
Job Insecurity ◽  
Musculoskeletal Symptoms ◽  
Short Term ◽  
Administrative Employees ◽  
The Individual ◽  
Not At Risk ◽  
Anxiety Depression ◽  
The Impact ◽  
Structured Questionnaire

The aim of this study was to estimate the short term consequences of job insecurity associated with a newly introduced mobility framework in Greece. In specific, the study examined the impact of job insecurity on anxiety, depression, and psychosomatic and musculoskeletal symptoms, two months after the announcement of the mobility framework. In addition the study also examined the “spill over” effects of job insecurity on employees not directly affected by the mobility framework. Personal interviews using a structured questionnaire were conducted for 36 university administrative employees awaiting repositioning, 36 coworkers not at risk, and 28 administrative employees of a local hospital not at risk. Compared to both control groups the employees in the anticipation phase of labor mobility had significantly worse scores for perceived stress, anxiety, depression, positive affect, negative affect, social support, marital discord, common somatic symptoms, and frequency of musculoskeletal pain. This study highlights the immediate detrimental effects of job insecurity on the physical, psychological, and social functioning of employees. There is a need for the development of front line interventions to prevent these effects from developing into chronic conditions with considerable cost for the individual and society in general.

Donor KIR Genotype Does Not Affect VZV Reactivation after Allogeneic Haematopoietic Stem Cell Transplantation.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3236-3236
Author(s):  
Sujaatha Narayanan ◽  
Sandeep Nagra ◽  
Premini Mahendra ◽  
Fiona J. Clark ◽  
Charles F. Craddock ◽  
...  
Keyword(s):  
At Risk ◽  
Stem Cell ◽  
Protective Effect ◽  
Haematopoietic Stem Cell ◽  
Cell Transplant ◽  
Allogeneic Hsct ◽  
Donor Type ◽  
The Individual ◽  
The Impact ◽  
Cmv Reactivation

Abstract Background. Varicella zoster virus (VZV) reactivation is a common occurrence after allogeneic haematopoietic stem cell transplant (HSCT) and a cause of significant morbidity. We have recently demonstrated the protective effect of donor KIR genotpye against cytomegalovirus (CMV) reactivation- specifically the protective effect of the broad ’B’ haplotype containing multiple activating KIR genes1. This retrospective study was designed to investigate whether donor KIR genotype confers an equivalent protective effect against VZV reactivation. Method. 152 patients who underwent allogeneic HSCT at a single centre were identified. Those with pre-transplant serology consistent with previous exposure to VZV were defined as at risk of VZV reactivation. All patients received aciclovir 800mg daily as routine prophylaxis. The diagnosis of VZV reactivation was made clinically. Cases of VZV reactivation were identified by examination of the case records. KIR genotyping was performed on donor DNA using PCR-SSP. The individual KIR genes KIR2DL1, 2DL2, 2DL3, 2DL5, 3DL1, 2DS1, 2DS2, 2DS3, 2DS4, 2DS5 and 3DS1, as well as the broad KIR haplotypes ’A’ and ’B’, were assessed by univariate and multivariate analysis for an effect on VZV reactivation. Also assessed was the impact of recipient HLA-C type, recipient HLA-Bw4/Bw6, donor type (sex-matched sibling, sex-mismatched sibling, volunteer unrelated), reduced intensity conditioning (RIC) regimen, the use of alemtuzemab as in vivo T cell depletion, CMV reactivation, and grade 2 or greater GVHD requiring steroid therapy. Results. 128 (84.2%) patients had evidence of past infection and thus were deemed at risk of VZV reactivation. Of these, 47 (36.7%) had clinical evidence of reactivation. 60% of transplants were from a donor possessing the broad ’B’ haplotype. The rate of reactivation in the presence of donor ’B’ haplotype was 40% compared to 32% when no donor ’B’ haplotype was present (p=0.237). None of the individual donor KIRs were shown to significantly reduce the rate of VZV reactivation. Neither the use of a RIC regimen nor the presence of alemtuzemab in the conditioning regimen were shown to have an impact. None of the other factors analysed were associated with an increased rate of zoster reactivation. Conclusion. Donor KIR genotype does not influence VZV reactivation after allogeneic HSCT. This contrasts with the findings for CMV reactivation. No influence of donor type, conditioning or GVHD could be demonstrated. This suggests 1) that there are differing mechanisms that control the reactivation of different Herpes viruses after transplantation and 2) that KIRs may have specificity for CMV.

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