Early Iron Deposition in Teeth of the Streamside Salamander, Ambystoma barbouri

2011 ◽  
Vol 45 (3) ◽  
pp. 336-338 ◽  
Author(s):  
Michael A. Anderson ◽  
Brian T. Miller
Keyword(s):  
Iron Deposition ◽  
Ambystoma Barbouri

Iron status in diabetes mellitus

2019 ◽  
pp. 7-12
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cells ◽  
Defense Mechanism ◽  
Acute Stress ◽  
Islet Cells ◽  
Iron Status ◽  
Acute Phase Reactant ◽  
Iron Deposition ◽  
Muscle Tissues ◽  
High Production

Diabetes mellitus can be defined as chronic metabolic disease which results from either relative or complete absence of insulin by the pancreatic beta islet cells. This in-turn may lead to hyperglycemia due to disturbances in the metabolism of glucose. In the human body, iron is con- sidered to be an effective pro-oxidant and participates in the generation of reactive oxygen species (ROS) such as hydroxyl radical. Because of the poor antioxidant defense mechanism of beta cells (low production of antioxidant enzymes such as catalase, glutathione peroxidase and dismutase), so they are highly prone to iron-induced oxidative stress and iron deposition in it and this will lead to apoptosis, and subsequently insulin deficiency. This iron deposition in beta cells will also lead to insulin resistance by reducing insulin extracting ability of the liver and inhibiting glucose uptake in muscle tissues and fats, this in turn will result in high production of hepatic glucose. Ferritin which is an acute phase reactant protein, that responds to acute stress like trauma, infections, tissue necrosis and surgery, it can produce diabetes mellitus either through inflammation or by increasing iron stores.

Noninvasive Assessment of Fat and Iron Deposition in the Liver by PDFF and T2* Measurement Using the 6-Point DIXON Method

2019 ◽  
Author(s):  
Yasue Takeuchi ◽  
Satoshi Saitoh ◽  
Shunichiro Fujiyama ◽  
Yusuke Kawamura ◽  
Hitomi Sezaki ◽  
...  
Keyword(s):  
Iron Deposition ◽  
Dixon Method ◽  
Noninvasive Assessment

scholarly journals Macrophage ferritin and iron deposition in the rat air pouch model of inflammatory synovitis.

1987 ◽  
Vol 46 (4) ◽  
pp. 334-338 ◽  
Author(s):  
C J Morris ◽  
D R Blake ◽  
S D Hewitt ◽  
J Lunec
Keyword(s):  
Iron Deposition ◽  
Air Pouch ◽  
Air Pouch Model

scholarly journals Correlative Microscopy to Localize and Characterize Iron Deposition in Alzheimer’s Disease

2020 ◽  
Vol 4 (1) ◽  
pp. 525-536
Author(s):  
Steven J. Madsen ◽  
Phillip S. DiGiacomo ◽  
Yitian Zeng ◽  
Maged Goubran ◽  
Yuanxin Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Electron Microscope ◽  
Oxidation State ◽  
Transmission Electron Microscope ◽  
Iron Deposition ◽  
Direct Link ◽  
Transmission Electron ◽  
And Oxidative Stress

Background: Recent evidence suggests that the accumulation of iron, specifically ferrous Fe2+, may play a role in the development and progression of neurodegeneration in Alzheimer’s disease (AD) through the production of oxidative stress. Objective: To localize and characterize iron deposition and oxidation state in AD, we analyzed human hippocampal autopsy samples from four subjects with advanced AD that have been previously characterized with correlative MRI-histology. Methods: We perform scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and electron energy loss spectroscopy (EELS) in the higher resolution transmission electron microscope on the surface and cross-sections of specific iron-rich regions of interest. Results: Specific previously analyzed regions were visualized using SEM and confirmed to be iron-rich deposits using EDS. Subsequent analysis using focused ion beam cross-sectioning and SEM characterized the iron deposition throughout the 3-D volumes, confirming the presence of iron throughout the deposits, and in two out of four specimens demonstrating colocalization with zinc. Analysis of traditional histology slides showed the analyzed deposits overlapped both with amyloid and tau deposition. Following higher resolution analysis of a single iron deposit using scanning transmission electron microscope (STEM), we demonstrated the potential of monochromated STEM-EELS to discern the relative oxidation state of iron within a deposit. Conclusion: These findings suggest that iron is present in the AD hippocampus and can be visualized and characterized using combined MRI and EM techniques. An altered relative oxidation state may suggest a direct link between iron and oxidative stress in AD. These methods thus could potentially measure an altered relative oxidation state that could suggest a direct link between iron and oxidative stress in AD. Furthermore, we have demonstrated the ability to analyze metal deposition alongside commonly used histological markers of AD pathology, paving the way for future insights into the molecular interactions between Aβ, tau, iron, and other putative metals, such as zinc.

1.009 NIGRAL IRON DEPOSITION OCCURS ACROSS MOTOR PHENOTYPIC EXPRESSIONS OF PARKINSON'S DISEASE

2012 ◽  
Vol 18 ◽  
pp. S12
Author(s):  
L. Jin ◽  
J. Wang ◽  
H. Jin ◽  
G. Fei ◽  
Y. Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Iron Deposition

scholarly journals Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects

2011 ◽  
Vol 43 (1) ◽  
pp. 213-219 ◽  
Author(s):  
Stylianos Kosmidis ◽  
Jose A. Botella ◽  
Konstantinos Mandilaras ◽  
Stephan Schneuwly ◽  
Efthimios M.C. Skoulakis ◽  
...  
Keyword(s):  
Late Onset ◽  
Iron Deposition ◽  
Optic Lobes
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